document.write("
"); document.write("
Joseph,\ E.K.*\ ; Kunze,\ L.H.*\ ; Schaefer,\ R.*\ ; Palumbo,\ G.*\ ; Kugelmann,\ B.*\ ; Wagner,\ S.*\ ; Lammich,\ S.*\ ; Feederle,\ R.\ ; Willem,\ M.*\ ; Werner,\ R.A.*\ ; Brendel,\ M.*\ ; Lindner,\ S.*
"); document.write("
Design, synthesis and preclinical evaluation of a brain-permeable PET tracer for P2Y12 receptor imaging in the brain.
"); document.write("
J. Med. Chem. 68, 15543-15562 (2025)
"); document.write("
"); document.write("
"); document.write("
Falke,\ S.*\ ; Lieske,\ J.*\ ; Herrmann,\ A.\ ; Loboda,\ J.*\ ; Karničar,\ K.*\ ; Günther,\ S.*\ ; Reinke,\ P.Y.A.*\ ; Ewert,\ W.*\ ; Usenik,\ A.*\ ; Lindič,\ N.*\ ; Sekirnik,\ A.*\ ; Dretnik,\ K.*\ ; Tsuge,\ H.*\ ; Turk,\ V.*\ ; Chapman,\ H.N.*\ ; Hinrichs,\ W.*\ ; Ebert,\ G.\ ; Turk,\ D.*\ ; Meents,\ A.*
"); document.write("
Structural elucidation and antiviral activity of covalent cathepsin L inhibitors.
"); document.write("
J. Med. Chem. 67, 7048-7067 (2024)
"); document.write("
"); document.write("
"); document.write("
Grygier,\ P.*\ ; Pustelny,\ K.*\ ; Nowak,\ J.*\ ; Golik,\ P.*\ ; Popowicz,\ G.M.\ ; Plettenburg,\ O.\ ; Dubin,\ G.*\ ; Cardoso Micu Menezes,\ F.M.\ ; Czarna,\ A.*
"); document.write("
Silmitasertib (CX-4945), a clinically used CK2-kinase inhibitor with additional effects on GSK3β and DYRK1A kinases: A structural perspective.
"); document.write("
J. Med. Chem. 66, 4009-4024 (2023)
"); document.write("
"); document.write("
"); document.write("
Kitel,\ R.*\ ; Surmiak,\ E.*\ ; Borggräfe,\ J.\ ; Kalinowska-Tluscik,\ J.*\ ; Golik,\ P.*\ ; Czub,\ M.*\ ; Uzar,\ W.*\ ; Musielak,\ B.*\ ; Madej,\ M.G.*\ ; Popowicz,\ G.M.\ ; Dubin,\ G.*\ ; Holak,\ T.A.*
"); document.write("
Discovery of inhibitory fragments that selectively target spire2-FMN2 interaction.
"); document.write("
J. Med. Chem. 66, 15715-15727 (2023)
"); document.write("
"); document.write("
"); document.write("
Narayanan,\ D.*\ ; Tran,\ K.T.*\ ; Pallesen,\ J.S.*\ ; Solbak,\ S.M.*\ ; Qin,\ Y.*\ ; Mukminova,\ E.*\ ; Luchini,\ M.*\ ; Vasilyeva,\ K.O.*\ ; González Chichón,\ D.*\ ; Goutsiou,\ G.*\ ; Poulsen,\ C.*\ ; Haapanen,\ N.*\ ; Popowicz,\ G.M.\ ; Sattler,\ M.\ ; Olagnier,\ D.*\ ; Gajhede,\ M.*\ ; Bach,\ A.*
"); document.write("
Development of noncovalent small-molecule Keap1-Nrf2 inhibitors by fragment-based drug discovery.
"); document.write("
J. Med. Chem. 65, 14481-14526 (2022)
"); document.write("
"); document.write("
"); document.write("
Hofmeister,\ A.*\ ; Jahn-Hofmann,\ K.*\ ; Brunner,\ B.*\ ; Helms,\ M.W.*\ ; Metz-Weidmann,\ C.*\ ; Krack,\ A.*\ ; Kurz,\ M.*\ ; Li,\ Z.*\ ; Weitzenberg,\ M.M.\ ; Pflimlin,\ E.*\ ; Plettenburg,\ O.\ ; Scheidler,\ S.*
"); document.write("
Syntheses of morpholine-based nucleotide analogs for hepatic siRNA targeting and stabilization.
"); document.write("
J. Med. Chem. 64, 6838–6855 (2021)
"); document.write("
"); document.write("
"); document.write("
Pallesen,\ J.S.*\ ; Narayanan,\ D.*\ ; Tran,\ K.T.*\ ; Solbak,\ S.M.*\ ; Marseglia,\ G.*\ ; Sørensen,\ L.M.E.*\ ; Høj,\ L.J.*\ ; Munafò,\ F.*\ ; Carmona,\ R.M.C.*\ ; Garcia,\ A.D.*\ ; Desu,\ H.L.*\ ; Brambilla,\ R.*\ ; Johansen,\ T.N.*\ ; Popowicz,\ G.M.\ ; Sattler,\ M.\ ; Gajhede,\ M.*\ ; Bach,\ A.*
"); document.write("
Deconstructing noncovalent kelch-like ECH-associated protein 1 (Keap1) inhibitors into fragments to reconstruct new potent compounds.
"); document.write("
J. Med. Chem. 64, 4623-4661 (2021)
"); document.write("
"); document.write("
"); document.write("
Dawidowski,\ M.\ ; Kalel,\ V.C.*\ ; Napolitano,\ V.*\ ; Fino,\ R.\ ; Schorpp,\ K.K.\ ; Emmanouilidis,\ L.\ ; Lenhart,\ D.\ ; Ostertag,\ M.S.\ ; Kaiser,\ M.*\ ; Kolonko,\ M.\ ; Tippler,\ B.*\ ; Schliebs,\ W.*\ ; Dubin,\ G.*\ ; Mäser,\ P.*\ ; Tetko,\ I.V.\ ; Hadian,\ K.\ ; Plettenburg,\ O.\ ; Erdmann,\ R.*\ ; Sattler,\ M.\ ; Popowicz,\ G.M.
"); document.write("
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity.
"); document.write("
J. Med. Chem. 63, 847-879 (2020)
"); document.write("
"); document.write("
"); document.write("
Hanke,\ S.*\ ; Tindall,\ C.*\ ; Pippel,\ J.*\ ; Ulbricht,\ D.*\ ; Pirotte,\ B.*\ ; Reboud-Ravaux,\ M.*\ ; Heiker,\ J.T.\ ; Sträter,\ N.*
"); document.write("
Structural studies on the inhibitory binding mode of aromatic coumarinic esters to human kallikrein-related peptidase 7.
"); document.write("
J. Med. Chem. 63, 5723-5733 (2020)
"); document.write("
"); document.write("
"); document.write("
Solbak,\ S.M.*\ ; Zang,\ J.*\ ; Narayanan,\ D.*\ ; Høj,\ L.J.*\ ; Bucciarelli,\ S.*\ ; Softley,\ C.\ ; Meier,\ S.*\ ; Langkilde,\ A.E.*\ ; Gotfredsen,\ C.H.*\ ; Sattler,\ M.\ ; Bach,\ A.*
"); document.write("
Developing inhibitors of the p47phox-p22phox protein-protein interaction by fragment-based drug discovery.
"); document.write("
J. Med. Chem. 63, 1156-1177 (2020)
"); document.write("
"); document.write("
"); document.write("
van de Plassche,\ M.A.T.*\ ; O\'Neill,\ T.J.\ ; Seeholzer,\ T.\ ; Turk,\ B.*\ ; Krappmann,\ D.\ ; Verhelst,\ S.H.L.*
"); document.write("
Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe.
"); document.write("
J. Med. Chem. 63, 3996-4004 (2020)
"); document.write("
"); document.write("
"); document.write("
Li,\ C.*\ ; Deng,\ X.*\ ; Zhang,\ W.*\ ; Xie,\ X.*\ ; Conrad,\ M.\ ; Liu,\ Y.*\ ; Friedmann Angeli,\ J.P.F.*\ ; Lai,\ L.*
"); document.write("
Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4.
"); document.write("
J. Med. Chem. 62, 266-275 (2019)
"); document.write("
"); document.write("
"); document.write("
Guarino,\ C.*\ ; Gruba,\ N.*\ ; Grzywa,\ R.*\ ; Dyguda-Kazimierowicz,\ E.*\ ; Hamon,\ Y.*\ ; Łȩgowska,\ M.*\ ; Skoreński,\ M.*\ ; Dallet-Choisy,\ S.*\ ; Marchand-Adam,\ S.*\ ; Kellenberger,\ C.*\ ; Jenne,\ D.\ ; Sieńczyk,\ M.*\ ; Lesner,\ A.*\ ; Gauthier,\ F.*\ ; Korkmaz,\ B.*
"); document.write("
Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis.
"); document.write("
J. Med. Chem. 61, 1858-1870 (2018)
"); document.write("
"); document.write("
"); document.write("
Kyriakou,\ E.\ ; Schmidt,\ S.\ ; Dodd,\ G.T.*\ ; Pfuhlmann,\ K.\ ; Simonds,\ S.E.*\ ; Lenhart,\ D.\ ; Geerlof,\ A.\ ; Schriever,\ S.C.\ ; de Angelis,\ M.\ ; Schramm,\ K.-W.\ ; Plettenburg,\ O.\ ; Cowley,\ M.A.*\ ; Tiganis,\ T.*\ ; Tschöp,\ M.H.\ ; Pfluger,\ P.T.\ ; Sattler,\ M.\ ; Messias,\ A.C.
"); document.write("
Celastrol promotes weight loss in diet-induced obesity by inhibiting the protein tyrosine phosphatases PTP1B and TCPTP in the hypothalamus.
"); document.write("
J. Med. Chem. 61, 11144-11157 (2018)
"); document.write("
"); document.write("
"); document.write("
Bertoletti,\ N.*\ ; Braun,\ F.*\ ; Lepage,\ M.*\ ; Möller,\ G.\ ; Adamski,\ J.\ ; Heine,\ A.*\ ; Klebe,\ G.*\ ; Marchais-Oberwinkler,\ S.*
"); document.write("
New insights into human 17\β-hydroxysteroid dehydrogenase type 14: First crystal structures in complex with a steroidal ligand and with a potent non-steroidal inhibitor.
"); document.write("
J. Med. Chem. 59, 6961-6967 (2016)
"); document.write("
"); document.write("
"); document.write("
Braun,\ F.*\ ; Bertoletti,\ N.*\ ; Möller,\ G.\ ; Adamski,\ J.\ ; Steinmetzer,\ T.*\ ; Salah,\ M.*\ ; Abdelsamie,\ A.S.*\ ; Van Koppen,\ C.J.*\ ; Heine,\ A.*\ ; Klebe,\ G.*\ ; Marchais-Oberwinkler,\ S.*
"); document.write("
First structure-activity relationship of 17\\β\-hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme.
"); document.write("
J. Med. Chem. 59, 10719-10737 (2016)
"); document.write("
"); document.write("
"); document.write("
Jagtap,\ P.K.\ ; Garg,\ D.\ ; Kapp,\ T.G.*\ ; Will,\ C.L.*\ ; Demmer,\ O.*\ ; Lührmann,\ R.*\ ; Kessler,\ H.*\ ; Sattler,\ M.
"); document.write("
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing.
"); document.write("
J. Med. Chem. 59, 10190-10197 (2016)
"); document.write("
"); document.write("
"); document.write("
Gilsbach,\ B.K.*\ ; Messias,\ A.C.\ ; Ito,\ G.*\ ; Sattler,\ M.\ ; Alessi,\ D.R.*\ ; Wittinghofer,\ A.*\ ; Kortholt,\ A.*
"); document.write("
Structural characterization of LRRK2 inhibitors.
"); document.write("
J. Med. Chem. 58, 3751-3756 (2015)
"); document.write("
"); document.write("
"); document.write("
Marchais-Oberwinkler,\ S.*\ ; Xu,\ K.*\ ; Wetzel,\ M.*\ ; Perspicace,\ E.*\ ; Negri,\ M.*\ ; Odermatt,\ A.*\ ; Möller,\ G.\ ; Adamski,\ J.\ ; Hartmann,\ R.W.*
"); document.write("
Structural optimization of 2,5-tiophene amides as highly potent and selective 17\\β\-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.
"); document.write("
J. Med. Chem. 56, 167-181 (2013)
"); document.write("
"); document.write("
"); document.write("
Wetzel,\ M.*\ ; Marchais-Oberwinkler,\ S.*\ ; Perspicace,\ E.*\ ; Möller,\ G.\ ; Adamski,\ J.\ ; Hartmann,\ R.W.*
"); document.write("
Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17\β-hydroxysteroid dehydrogenase type 2 (17\β-HSD2) inhibitors.
"); document.write("
J. Med. Chem. 54, 7547-7557 (2011)
"); document.write("
"); document.write("
"); document.write("
Garg,\ D.\ ; Henrich,\ S.\ ; Salo-Ahen,\ O.M.H.\ ; Myllykallio,\ H.\ ; Costi,\ M.P.\ ; Wade,\ R.C.
"); document.write("
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.
"); document.write("
J. Med. Chem. 53, 6539-6549 (2010)
"); document.write("
"); document.write("
"); document.write("
Adelt,\ S.*\ ; Plettenburg,\ O.*\ ; Stricker,\ R.*\ ; Reiser,\ G.*\ ; Altenbach,\ H.J.*\ ; Vogel,\ G.*
"); document.write("
Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates.
"); document.write("
J. Med. Chem. 42, 1262-1273 (1999)
"); document.write("
"); document.write("
"); document.write("
Adelt,\ S.*\ ; Plettenburg,\ O.\ ; Stricker,\ R.*\ ; Reiser,\ G.*\ ; Altenbach,\ H.J.*\ ; Vogel,\ G.*
"); document.write("
Enzyme-Assisted Total Synthesis of the Optical Antipodes \D-myo\-Inositol 3,4,5-Trisphosphate and \D-myo\-Inositol 1,5,6-Trisphosphate: Aspects of Their Structure-Activity Relationship to Biologically Active Inositol Phosphates.
"); document.write("
J. Med. Chem. 42, 1262-1273 (1999)
"); document.write("
"); document.write("
"); document.write("
Richert,\ C.*\ ; Wessels,\ J.M.\ ; Müller,\ M.D.*\ ; Kisters,\ M.*\ ; Benninghaus,\ T.*\ ; Goetz,\ A.E.*
"); document.write("
Photodynamic antitumor agents: \β-Methoxyethyl groups give access to functionalized porphycenes and enhance cellular uptake and activity.
"); document.write("
J. Med. Chem. 37, 2797-2807 (1994)
"); document.write("
"); document.write("
"); document.write("
Strobl,\ G.R.\ ; Kruedener,\ S. von\ ; Stöckigt,\ J.\ ; Guengerich,\ F.P.\ ; Wolff,\ T.
"); document.write("
Development of a Pharmacophore for Inhibition of Human Liver Cytochrome P-450 2D6: Molecular Modeling and Inhibition Studies.
"); document.write("
J. Med. Chem. 36, 1136-1145 (1993)
"); document.write("
"); document.write("
"); document.write("
Strobl,\ G.R.\ ; von Kruedener,\ S.*\ ; Stöckigt,\ J.H.H.*\ ; Guengerich,\ F.P.*\ ; Wolff,\ T.
"); document.write("
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modeling and inhibition studies.
"); document.write("
J. Med. Chem. 36, 1136-1145 (1993)
"); document.write("
");