McCarrick, S.* ; Delaval, M.N. ; Dauter, U.M.* ; Krais, A.M.* ; Snigireva, A.* ; Abera, A.* ; Broberg, K.* ; Eriksson, A.C.* ; Isaxon, C.* ; Gliga, A.R.*
Toxicity of particles derived from combustion of Ethiopian traditional biomass fuels in human bronchial and macrophage-like cells.
Arch. Toxicol. 98, 1515-1532 (2024)
Escher, B.I.* ; Altenburger, R.* ; Blüher, M. ; Colbourne, J.K.* ; Ebinghaus, R.* ; Fantke, P.* ; Hein, M.* ; Köck, W.* ; Kümmerer, K.* ; Leipold, S.* ; Li, X.* ; Scheringer, M.* ; Scholz, S.* ; Schloter, M. ; Schweizer, P.J.* ; Tal, T.* ; Tetko, I.V. ; Traidl-Hoffmann, C. ; Wick, L.Y.* ; Fenner, K.*
Modernizing persistence-bioaccumulation-toxicity (PBT) assessment with high throughput animal-free methods.
Arch. Toxicol. 97, 1267-1283 (2023)
Zeitlmayr, S.* ; Zierler, S.* ; Staab-Weijnitz, C.A. ; Dietrich, A.* ; Geiger, F.* ; Horgen, F.D.* ; Gudermann, T.* ; Breit, A.*
TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts.
Arch. Toxicol. 96, 2767-2783 (2022)
Kozlova, E.V.* ; Valdez, M.C.* ; Denys, M.E.* ; Bishay, A.E.* ; Krum, J.M.* ; Rabbani, K.M.* ; Carrillo, V.* ; Gonzalez, G.M.* ; Lampel, G.* ; Tran, J.D.* ; Vazquez, B.M.* ; Anchondo, L.M.* ; Uddin, S.A.* ; Huffman, N.M.* ; Monarrez, E.* ; Olomi, D.S.* ; Chinthirla, B.D.* ; Hartman, R.E.* ; Kodavanti, P.R.S.* ; Chompre, G.* ; Phillips, A.L.* ; Stapleton, H.M.* ; Henkelmann, B. ; Schramm, K.-W. ; Curras-Collazo, M.C.*
Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.
Arch. Toxicol., DOI: 10.1007/s00204-021-03163-4 (2021)
Albrecht, W.* ; Kappenberg, F.* ; Brecklinghaus, T.* ; Stoeber, R.* ; Marchan, R.* ; Zhang, M.* ; Ebbert, K.* ; Kirschner, H.* ; Grinberg, M.* ; Leist, M.* ; Moritz, W.* ; Cadenas, C.* ; Ghallab, A.* ; Reinders, J.* ; Vartak, N.* ; van Thriel, C.* ; Golka, K.* ; Tolosa, L.* ; Castell, J.V.* ; Damm, G.* ; Seehofer, D.* ; Lampen, A.* ; Braeuning, A.* ; Buhrke, T.* ; Behr, A.C.* ; Oberemm, A.* ; Gu, X.* ; Kittana, N.* ; van de Water, B.* ; Kreiling, R.* ; Fayyaz, S.* ; van Aerts, L.* ; Smedsrød, B.* ; Ellinger-Ziegelbauer, H.* ; Steger-Hartmann, T.* ; Gundert-Remy, U.* ; Zeigerer, A. ; Ullrich, A.* ; Runge, D.* ; Lee, S.M.L.* ; Schiergens, T.S.* ; Kuepfer, L.* ; Aguayo-Orozco, A.* ; Sachinidis, A.* ; Edlund, K.* ; Gardner, I.* ; Rahnenführer, J.* ; Hengstler, J.G.*
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
Arch. Toxicol. 93, 1609-1637 (2019)
Fritsch-Decker, S.* ; Marquardt, C.* ; Stöger, T. ; Diabaté, S.* ; Weiss, C.*
Revisiting the stress paradigm for silica nanoparticles: Decoupling of the anti-oxidative defense, pro-inflammatory response and cytotoxicity.
Arch. Toxicol. 92, 2163-2174 (2018)
Klaus, V. ; Bastek, H.* ; Damme, K.* ; Collins, L.B.* ; Frötschl, R.* ; Benda, N.* ; Lutter, D. ; Ellinger-Ziegelbauer, H.* ; Swenberg, J.A.* ; Dietrich, D.R.* ; Stemmer, K.
Time-matched analysis of DNA adduct formationand early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
Arch. Toxicol. 91, 3427–3438 (2017)
Schmid, G.* ; Kreyling, W.G. ; Simon, U.*
Toxic effects and biodistribution of ultrasmall gold nanoparticles.
Arch. Toxicol. 91, 3011–3037 (2017)
Dilger, M.* ; Orasche, J. ; Zimmermann, R. ; Paur, H.R.* ; Diabaté, S.* ; Weiss, C.*
Toxicity of wood smoke particles in human A549 lung epithelial cells: The role of PAHs, soot and zinc.
Arch. Toxicol. 90, 3029-3044 (2016)
Dietrich, D.* ; von Aulock, S.* ; Marquardt, H.W.J.* ; Blaauboer, B.J.* ; Dekant, W.* ; Kehrer, J.* ; Hengstler, J.G.* ; Collier, A.C.* ; Gori, G.B.* ; Pelkonen, O.* ; Lang, F.* ; Nijkamp, F.P.* ; Stemmer, K. ; Li, A.* ; Savolainen, K.* ; Hayes, A.W.* ; Gooderham, N.* ; Harvey, A.*
Open letter to the European commission: Scientifically unfounded precaution drives European commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles.
Arch. Toxicol. 87, 1739-1741 (2013)
Gibson, N.* ; Holzwarth, U.* ; Abbas, K.* ; Simonelli, F.* ; Kozempel, J.* ; Cydzik, I.* ; Cotogno, G.* ; Bulgheroni, A.* ; Gilliland, D.* ; Ponti, J.* ; Franchini, F.* ; Marmorato, P.* ; Stamm, H.* ; Kreyling, W.G. ; Wenk, A. ; Semmler-Behnke, M. ; Buono, S.* ; Maciocco, L.* ; Burgio, N.
Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators.
Arch. Toxicol. 85, 751-773 (2011)
Csanády, G.A. ; Göen, T.* ; Klein, D. ; Drexler, H.* ; Filser, J.G.
Trichloroacetic acid in urine as biological exposure equivalent for low exposure concentrations of trichloroethene.
Arch. Toxicol. 84, 897-902 (2010)
Slama, R.* ; Cyrys, J. ; Herbarth, O.* ; Wichmann, H.-E. ; Heinrich, J.
A further plea for rigorous science and explicit disclosure of potential conflicts of interest.
Arch. Toxicol. 83, 293-295 (2009)
Carstens, J. ; Csanády, G.A. ; Faller, T.H. ; Filser, J.G.
Human inhalation exposure to ethylene glycol.
Arch. Toxicol. 77, 425-432 (2003)
Klein, D.* ; Lichtmannegger, J. ; Finckh, M. ; Summer, K.H.
Gene expression in the liver of Long-Evans cinnemon rats during the development of hepatitis.
Arch. Toxicol. 77, 568-575 (2003)
Csanády, G.A. ; Oberste-Frielinghaus, H.R. ; Semder, B. ; Baur, C.* ; Schneider, K.T.* ; Filser, J.G.
Distribution and unspecific protein binding of the xenoestrogens bisphenol A and daidzein.
Arch. Toxicol. 76, 299-305 (2002)
Son, D.S.* ; Rozman, K.K.*
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines.
Arch. Toxicol. 76, 404-413 (2002)
Csanády, G.A. ; Filser, J.G.
The relevance of physical activity for the kinetics of inhaled gaseous substances.
Arch. Toxicol. 74, 663-672 (2001)
Kessler, W. ; Phokha, W. ; Csanády, G.A.* ; Filser, J.G.
No background concentrations of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in blood of rats.
Arch. Toxicol. 75, 62-64 (2001)
Laube, B. ; Winkler, S. ; Ladstetter, B.* ; Scheller, T.* ; Schwarz, L.R.
Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora.
Arch. Toxicol. 74, 379-387 (2000)
Viluksela, M.* ; Unkila, M.* ; Pohjanvirta, R.* ; Tuomisto, J.T.* ; Stahl, B.U. ; Rozman, K.K. ; Tuomisto, J.*
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains.
Arch. Toxicol. 73, 323-336 (1999)
Viluksela, M.* ; Unkila, M.* ; Pohjanvirta, R.* ; Tuomisto, J.T.* ; Stahl, B.U.* ; Rozman, K.K.* ; Tuomisto, J.*
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains.
Arch. Toxicol. 73, 323-336 (1999)
Summer, K.H. ; Klein, D.* ; Lichtmannegger, J. ; Wolff, T.
2-Chloro-acetophenone is an effective glutathione depletor in isolated rat hepatocytes.
Arch. Toxicol. 71, 127-129 (1996)
Csanády, G.A. ; Filser, J.G. ; Becka, M.
Statistical analysis of toxicokinetic data by nonlinear regression [1].
Arch. Toxicol. 67, 227-230 (1993)
Filser, J.G. ; Schwegler, U. ; Csanády, G.A. ; Greim, H.A. ; Kreuzer, P.E. ; Kessler, W.
Species-specific pharmacokinetics of styrene in rat and mouse.
Arch. Toxicol. 67, 517-530 (1993)
Johanson, G.A. ; Filser, J.G.
A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation.
Arch. Toxicol. 67, 151-163 (1993)
Filser, J.G.
The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.
Arch. Toxicol. 66, 1-10 (1992)
Filser, J.G. ; Denk, B. ; Törnqvist, M. ; Kessler, W. ; Ehrenberg, L.
Pharmacokinetics of Ehtylene in Man; Body Burden with Ethylene Oxide and Hydroxyethylation of Hemoglobin due to Endogenous and Environmental Ethylene.
Arch. Toxicol. 66, 157-163 (1992)
Filser, J.G. ; Denk, B. ; Törnqvist, M.A. ; Kessler, W. ; Ehrenberg, L.G.
Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene.
Arch. Toxicol. 66, 157-163 (1992)
Laib, R.J. ; Tucholski, M. ; Filser, J.G. ; Csanády, G.A.
Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats.
Arch. Toxicol. 66, 310-314 (1992)
Scheding, S.* ; Loeffler, M.* ; Anselstetter, V.* ; Wichmann, H.-E.
A mathematical approach to benzo[a]pyrene-induced hematotoxicity.
Arch. Toxicol. 66, 546-550 (1992)
Stahl, B.U. ; Kettrup, A. ; Rozman, K.K.
Comparative Toxicity of Four Chlorinated Dibenzo-p-dioxins (CDDs) and their Mixture. Part I: Acute Toxicity and Toxic Equivalency Factors (TEFs).
Arch. Toxicol. 66, 471-477 (1992)
Stahl, B.U. ; Kettrup, A. ; Rozman, K.K.
Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture - Part I: Acute toxicity and toxic equivalency factors (TEFs).
Arch. Toxicol. 66, 471-477 (1992)
Weber, L.W.D. ; Lebofsky, M. ; Stahl, B.U. ; Kettrup, A. ; Rozman, K.K.
Comparative Toxicity of Four Chlorinated Dibenzo-p-dioxins (CDDs) and their Mixture. Part II: Structure-activity Relationships with Inhibition of Hepatic Phosphoenolpyruvate Carbocykinase, Pyruvate Carbocylase, and gamma-glutamyl Transpeptidase Activities.
Arch. Toxicol. 66, 478-483 (1992)
Weber, L.W.D. ; Lebofsky, M. ; Stahl, B.U. ; Kettrup, A. ; Rozman, K.K.
Comparative Toxicity of Four Chlorinated Dibenzo-p-dioxins (CDDs) and their Mixture. Part III: Structure-activity Relationship with Increased Plasma Tryptophan Levels, but no Relationship to Hepatic Ethoxyresorufin o-deethylase Activity.
Arch. Toxicol. 66, 484-488 (1992)
Boadi, W.Y. ; Yannai, S. ; Urbach, J. ; Brandes, J.M. ; Summer, K.H.
Transfer and accumulation of cadmium, and the level of metallothionein in perfused human placentae.
Arch. Toxicol. 65, 18-23 (1991)
Csanády, G.A. ; Freise, D. ; Denk, B. ; Filser, J.G. ; Cornet, M. ; Rogiers, V. ; Laib, R.J.
Investigation of Species Differences in Isobutene (2-methylpropene) Metabolism Between Mice and Rats.
Arch. Toxicol. 65, 100-105 (1991)
Filser, J.G. ; Johanson, G.
Low Apparent Alveolar Ventilations in Closed Chamber Gas Uptake Experiments.
Arch. Toxicol. (1991)
Kreuzer, P.E. ; Kessler, W. ; Welter, H.F.* ; Baur, C.M.* ; Filser, J.G.
Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man.
Arch. Toxicol. 65, 59-67 (1991)
Mertschenk, B.* ; Bornemann, W.* ; Filser, J.G. ; von Meyer, L.* ; Rust, U.* ; Schneider, J.C.* ; Gloxhuber, C.*
Urinary excretion of acetylcyanamide in rat and human after oral and dermal application of hydrogen cyanamide (H2NCN).
Arch. Toxicol. 65, 268-272 (1991)
Rozman, K.K. ; Pfeifer, B. ; Kerecsen, L. ; Alper, R.H.
Is a Serotonergic Mechanism Involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Appetite Suppression in the Sprague-Dawley Rat?.
Arch. Toxicol. 65, 124-128 (1991)
Weber, L.W.D. ; Lebofsky, M. ; Greim, H. ; Rozman, K.K.
Key Enzymes of Gluconeogenesis are Dose-Dependently Reduced in 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-treated Rats.
Arch. Toxicol. 65, 119-123 (1991)
Weber, L.W.D. ; Zesch, A. ; Rozman, K.K.
Penetration, Distribution and Kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Human Skin in Vitro.
Arch. Toxicol. 65, 421-428 (1991)
Weber, L.W.D. ; Lebofsky, M.* ; Greim, H.A. ; Rozman, K.K.
Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats.
Arch. Toxicol. 65, 119-123 (1991)
Bartsch, R. ; Klein, D.A. ; Summer, K.H.
The Cd-Chelex assay: A new sensitive method to determine metallothionein containing zinc and cadmium.
Arch. Toxicol. 64, 177-180 (1990)
Denk, B. ; Filser, J.G. ; Deml, E. ; Kessler, W. ; Shen, J. ; Oesterle, D.
Dose-dependent emergence of preneoplastic foci in rat livers after exposure to 2-nitropropane.
Arch. Toxicol. 64, 329-331 (1990)
Gorski, J.R. ; Weber, L.W.D. ; Rozman, K.K.
Reduced Gluconeogenesis in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-treated Rats.
Arch. Toxicol. 64, 66-71 (1990)
Halbach, S.
Mercury compounds: Lipophilicity and toxic effects on isolated myocardial tissue.
Arch. Toxicol. 64, 315-319 (1990)
Kessler, W. ; Heilmaier, H. ; Kreuzer, P. ; Shen, J.H. ; Filser, M. ; Filser, J.G.
Spectrophotometric determination of pyrrole-like substances in urine of rat and man: An assay for the evaluation of 2,5-hexanedione formed from n-hexane.
Arch. Toxicol. 64, 242-246 (1990)
Deml, E. ; Oesterle, D.
Incidence of Preneoplastic Foci in Rat Liver Dependent on Different Promoting Schemes.
Arch. Toxicol. 13, 233-236 (1989)
Denk, B. ; Baumann, M. ; Filser, J.G.
Pharmacokinetics and hepatotoxicity of 2-nitropropane in rats.
Arch. Toxicol. 63, 330-332 (1989)
Ziegler-Skylakakis, K. ; Summer, K.H. ; Andrae, U.
Mutagenicity and cytotoxicity of 2-chlorobenzylidene malonitrile (CS) and metabolites in V79 Chinese hamster cells.
Arch. Toxicol. 63, 314-319 (1989)
Ziegler-Skylakakis, K. ; Summer, K.H. ; Andrae, U.
Mutagenicity and cytotoxicity of 2-chlorobenzylidene malonitrile (CS) and metabolites in V79 Chinese hamster cells.
Arch. Toxicol. 63, 314-319 (1989)
Filser, J. ; Dogra, S. ; Cojocel, C. ; Greim, H. ; Regel, U. ; Desch, F. ; Robertson, L.W.
Long-term Effects of Commercial and Congeneric Polychlorinated Biphenyls on Ethane Production and malone Dialdehyde Levels Indicators of In-vivo lipid Peroxidation.
Arch. Toxicol. 62, 369-374 (1988)
Filser, J. ; Golka, K. ; Peter, H. ; Denk, B.
Pharmacokinetics of Propylene and its Reactive Metabolite Propylene Oxide in Sprague-Dawley Rats.
Arch. Toxicol. (1988)
Filser, J. ; Shen, J. ; Kessler, W. ; Denk, B.
Metabolism and Endogenous Production of Ethylene in Humans and Rats.
Arch. Toxicol. (1988)
Weber, L.W.D. ; Rozman, K.K. ; Gorski, J.R.
Tissue-Specific Alterations of De Novo Fatty Acid Synthesis in 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-treated Rats.
Arch. Toxicol. (1988)
Deml, E. ; Oesterle, D.
Dose response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay.
Arch. Toxicol. 60, 209-211 (1987)
Filser, J.G. ; Peter, H.G. ; Bolt, H.M. ; Fedtke, N.
Pharmacokinetics of the neurotoxin n-hexane in rat and man.
Arch. Toxicol. 60, 77-80 (1987)
Muzi, G. ; Girski, J.R. ; Rozman, K.K.
Composition of Diet Modifies Toxicity of 2,3,7,8- tetrachlorodibenzo- p- dioxin (TCDD) in Cold- adapted Rats.
Arch. Toxicol. 61, 34-39 (1987)
Wolff, T. ; Distlerath, L.M.* ; Worthington, M.T.* ; Guengerich, F.P.*
Human liver debrisoquine 4-hydroxylase: Test for specifity toward various monooxygenase substrates and model of the active site.
Arch. Toxicol. 60, 89-90 (1987)
Rozman, K.K. ; Greim, H.A.
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in cold-adapted rats.
Arch. Toxicol. 59, 211-215 (1986)
Halbach, S.
The octanol/water distribution of mercury compounds.
Arch. Toxicol. 57, 139-141 (1985)
Ziegler-Skylakakis, K. ; Rossberger, S. ; Andrae, U.
Thiourea induces DNA repair synthesis in primary rat hepatocyte cultures and gene mutations in V79 Chinese hamster cells.
Arch. Toxicol. 58, 5-9 (1985)
Baumann, M. ; Schäffer, E.H. ; Greim, H.A.
Short-term studies with the cryptating agent hexaoxa-diaza-bicyclo-hexacosane in rats.
Arch. Toxicol. 55, 427-429 (1984)
Schmahl, W.G. ; Török, P. ; Kriegel, H.
Embryotoxocity of 5-azacytidine in mice. Phase and dose-specificity studies.
Arch. Toxicol. 55, 143-147 (1984)
Malik, J.K. ; Lay, J.P. ; Klein, W. ; Korte, F.
Biotransformation and disposition of the coumaphos metabolite 3-chloro-4-methyl-(4-14C)-7-hydroxycoumarin in rats.
Arch. Toxicol. 48, 51-59 (1981)
Neuhaeuser-Klaus, A.
An approach towards the standardization of the mammalian spot test.
Arch. Toxicol. 48, 229-243 (1981)
Greim, H.A.
Isolated cell systems as a tool in toxicological research.
Arch. Toxicol. 44, 209-210 (1980)
Greim, H.A. ; Göggelmann, W. ; Summer, K.H. ; Wolff, T.
Mutagenicity testing with Salmonella microsome test.
Arch. Toxicol. 46, 31-40 (1980)
Hesse, S. ; Wolff, T. ; Mezger, M.
Involvement of phenolic metabolites in the irreversible protein-binding of 14C-bromobenzene catalysed by rat liver microsomes.
Arch. Toxicol. 45, 358-362 (1980)
Greim, H.A. ; Hofmann, A.F. ; Schwenk, M.
Chimpanzees sulfate lithocholate similar to man.
Arch. Toxicol. 1, 199 (1978)
Müsch, H.R. ; Bornhausen, M. ; Kriegel, H. ; Greim, H.A.
Methylmercury chloride induces learning deficits in prenatally treated Rats.
Arch. Toxicol. 40, 103-108 (1978)
Toeroek, P.
Verzögerte Implantation und frühembryonale Keimschaden bei der Maus nach Applikation des PCB: 2,2'-Dichlorbiphenyl.
Arch. Toxicol. 40, 249-254 (1978)