TY  - JOUR
AB  - Older adults experience a higher prevalence of multiple chronic conditions (MCCs). Establishing the presence and pattern of MCCs in individuals or populations is important for healthcare delivery, research, and policy. This report describes four emerging approaches and discusses their potential applications for enhancing assessment, treatment, and policy for the aging population. The National Institutes of Health convened a 2-day panel workshop of experts in 2018. Four emerging models were identified by the panel, including classification and regression tree (CART), qualifying comorbidity sets (QCS), the multimorbidity index (MMI), and the application of omics to network medicine. Future research into models of multiple chronic condition assessment may improve understanding of the epidemiology, diagnosis, and treatment of older persons.
AU  - Suls, J.*
AU  - Salive, M.E.*
AU  - Koroukian, S.M.*
AU  - Alemi, F.*
AU  - Silber, J.H.*
AU  - Kastenmüller, G.
AU  - Klabunde, C.N.*
C1  - 65416
C2  - 52456
SP  - 2498-2507
TI  - Emerging approaches to multiple chronic condition assessment.
JO  - J. Am. Geriatr. Soc.
VL  - 70
IS  - 9
PY  - 2022
SN  - 0002-8614
ER  - 

TY  - JOUR
AU  - Huang, Y.M.*
AU  - Hong, X.Z.*
AU  - Shen, J.
AU  - Huang, Y.*
AU  - Zhao, H.L.*
C1  - 58807
C2  - 48357
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 940-942
TI  - China's oldest coronavirus survivors.
JO  - J. Am. Geriatr. Soc.
VL  - 68
IS  - 5
PB  - Wiley
PY  - 2020
SN  - 0002-8614
ER  - 

TY  - JOUR
AB  - Objectives: To identify determinants of incident malnutrition in community-dwelling older adults. Design: Meta-analysis of 6 community-based longitudinal datasets with follow-up of 1 to 3 years. Setting: Datasets from MaNuEL (MalNutrition in the Elderly) partners were included: 3 studies from Germany and 1 each from Ireland, the Netherlands, and New Zealand. Participants: community-dwelling adults aged 65 and older (N=4,844). Measurement: The same definition of incident malnutrition was used for all cohorts (body mass index < 20.0 kg/m2at follow-up or weight loss ≥10 % between baseline and follow-up). Twenty-one potential baseline determinants from 7 domains (demographic, nutritional, lifestyle, social, psychological, physical functioning, medical) and 2 follow-up variables (hospitalization, falls) were harmonized for all studies. Binary logistic regression analyses were performed to assess the association between each variable, adjusted for specific confounders, and incident malnutrition. Combined odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects meta-analyses. Results: Studies included between 209 and 1,841 participants without malnutrition at baseline; mean age ranged from 71.7 to 84.6. Incidence of malnutrition varied from 5.1% and 17.2%. Meta-analyses identified 6 variables as independent determinants of incident malnutrition; with increasing age, the risk of developing malnutrition increased continuously. Unmarried, separated, or divorced participants were more likely to develop malnutrition than married participants, whereas no association was found for widowed participants. Participants with difficulty walking (OR=1.41, 95% CI=1.06–1.89) or difficulty climbing stairs (OR=1.45, 95% CI=1.14–1.85) and those who were hospitalized before baseline (OR=1.49, 95% CI=1.25–1.76) and during follow-up (OR=2.02, 95% CI=1.41–2.88) had higher odds of incident malnutrition. Conclusion: In this harmonized meta-analysis based on prospective data of older, community-dwelling adults, age, marital status, limitations with walking and climbing stairs, and hospitalization were identified as determinants of incident malnutrition.
AU  - Streicher, M.*
AU  - van Zwienen-Pot, J.*
AU  - Bardon, L.*
AU  - Nagel, G.*
AU  - The, R.*
AU  - Meisinger, C.
AU  - Colombo, M.
AU  - Torbahn, G.*
AU  - Kiesswetter, E.*
AU  - Flechtner-Mors, M.*
AU  - Denkinger, M.*
AU  - Rothenbacher, D.*
AU  - Thorand, B.
AU  - Ladwig, K.-H.
AU  - Corish, C.A.*
AU  - Clarke, M.*
AU  - Kerse, N.*
AU  - Muru-Lanning, M.*
AU  - Gibney, E.R.*
AU  - O'Connor, E.M.*
AU  - Visser, M.*
AU  - Volkert, D.*
C1  - 54180
C2  - 45429
SP  - 2335-2343
TI  - Determinants of incident malnutrition in community-dwelling older adults: A MaNuEL multicohort meta-analysis.
JO  - J. Am. Geriatr. Soc.
VL  - 66
IS  - 12
PY  - 2018
SN  - 0002-8614
ER  - 

TY  - JOUR
AB  - Objectives:  To evaluate the prevalence of silent stroke and its associated consequences on physical, cognitive, and emotional functioning in an elderly population.
      	
      	
      		
      			Design:  Population-based cross-sectional survey.
      	
      	
      		
      			Setting:  The Memory and Morbidity in Augsburg Elderly project in the Augsburg region of southern Germany.
      	
      	
      		
      			Participants:  Two hundred sixty-seven community-dwelling persons aged 65 to 83.
      	
      	
      		
      			Measurements:  The presence of silent stroke was determined using magnetic resonance imaging brain scan and a single question asking for physician-diagnosed stroke in each participant. The health effect of silent stroke was assessed using rating scales for self-perceived health status (36-item short-form health survey), activities of daily living (ADLs) and instrumental ADLs, cognitive function, and depression (Center for Epidemiologic Studies Depression scale).
      	
      	
      		
      			Results:  Just fewer than 13% (12.7%) of participants were affected by silent stroke. Silent stroke was associated with a history of hypertension, heart surgery, and elevated C-reactive protein. Individuals with silent stroke showed impairments on the Mini-Mental State Examination test and in the cognitive domains of memory, procedural speed, and motor performance.
      	
      	
      		
      			Conclusion:  The presence of silent stroke has a considerable effect on cognitive performance in those affected. Determining the presence of silent stroke using brain imaging may contribute to identifying individuals at risk for developing gradual neurological deficits.
      	
      
      
      	 
AU  - Schmidt, W.-P.*
AU  - Roesler, A.*
AU  - Kretzschmar, K.*
AU  - Ladwig, K.-H.
AU  - Junker, R.*
AU  - Berger, K.*
C1  - 1260
C2  - 22007
SP  - 1045-1050
TI  - Functional and cognitive consequences of silent stroke discovered using brain magnetic resonance imaging in an elderly population.
JO  - J. Am. Geriatr. Soc.
VL  - 52
IS  - 7
PY  - 2004
SN  - 0002-8614
ER  -