TY  - JOUR
AU  - Ionescu, T.M.*
AU  - Amend, M.*
AU  - Adamatzky, K.*
AU  - Born, J.
AU  - Hallschmid, M.
AU  - Ritze, Y.*
AU  - Pichler, B.J.*
C1  - 56628
C2  - 47115
CY  - 2455 Teller Rd, Thousand Oaks, Ca 91320 Usa
SP  - 575-576
TI  - Long-term high-sugar diet increases reward-related neural responses to an acute glucose challenge as revealed by simultaneous [F-18]FDG PET/fMRI.
JO  - J. Cereb. Blood Flow Metab.
VL  - 39
PB  - Sage Publications Inc
PY  - 2019
SN  - 0271-678X
ER  - 

TY  - JOUR
AB  - Current functional neuroimaging methods are not adequate for high-resolution whole-brain visualization of neural activity in real time. Here, we show imaging of fast hemodynamic changes in deep mouse brain using fully noninvasive acquisition of five-dimensional optoacoustic data from animals subjected to oxygenation stress. Multispectral video-rate acquisition of three-dimensional tomographic data enables simultaneous label-free assessment of multiple brain hemodynamic parameters, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin, in real time. The unprecedented results indicate that the proposed methodology may serve as a powerful complementary, and potentially superior, method for functional neuroimaging studies in rodents.
AU  - Gottschalk, S.
AU  - Fehm, T.
AU  - Dean-Ben, X.L.
AU  - Razansky, D.
C1  - 43099
C2  - 36062
CY  - New York
SP  - 531-535
TI  - Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography.
JO  - J. Cereb. Blood Flow Metab.
VL  - 35
IS  - 4
PB  - Nature Publishing Group
PY  - 2015
SN  - 0271-678X
ER  - 

TY  - JOUR
AB  - Corticotropin-releasing hormone receptor type 1 (CRH-R1)-deficient mice display reduced anxiety-like behavior, a chronic corticosterone deficit, and an impaired neuroendocrine stress response caused by disruption of the hypothalamic-pituitary-adrenocortical (HPA) axis. The molecular substrates and pathways of CRH/CRH-R1-dependent signaling mechanisms underlying the behavioral phenotype as well as the consequences of lifelong glucocorticoid deficit remain largely obscure. To dissect involved neuronal circuitries, we performed comparative expression profiling of brains of CRH-R1 mutant and wild-type mice using our custom made MPIP (Max Planck Institute of Psychiatry) 17k cDNA microarray. Microarray analysis yielded 107 genes showing altered expression levels when comparing CRH-R1 knockout mice with wild-type littermates. A significant proportion of differentially expressed genes was related to control of HPA and hypothalamic-pituitary-thyroid (HPT) axes reflecting not only the disturbance of the HPA axis in CRH-R1 mutant mice but also the interplay of both neuroendocrine systems. The spatial analysis of regulated genes revealed a prevalence for genes expressed in the cerebral microvasculature. This phenotype was confirmed by the successful cross-validation of regulated genes in CRH overexpressing mice. Analysis of the cerebral vasculature of CRH-R1 mutant and CRH overexpressing mice revealed alterations of functional rather than structural properties. A direct role of the CRH/CRH-R1 system was supported by demonstrating Crhr1 expression in the adult murine cerebral vasculature. In conclusion, these data suggest a novel, previously unknown role of the CRH/CRH-R1 system in modulating neurovascular gene expression and function.
AU  - Deussing, J.M.*
AU  - Kühne, C.*
AU  - Pütz, B.*
AU  - Panhuysen, M.
AU  - Breu, J.*
AU  - Stenzel-Poore, M.P.*
AU  - Holsboer, F.*
AU  - Wurst, W.
C1  - 1763
C2  - 24848
SP  - 1476-1495
TI  - Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.
JO  - J. Cereb. Blood Flow Metab.
VL  - 27
IS  - 8
PB  - Nature Publ. Group
PY  - 2007
SN  - 0271-678X
ER  - 

TY  - JOUR
AU  - Beck, H.
AU  - Voswinckel, R.*
AU  - Wagner, S.*
AU  - Ziegelhoeffer, T.*
AU  - Heil, M.*
AU  - Helisch, A.*
AU  - Schaper, W.*
AU  - Acker, T.*
AU  - Hatzopoulos, A.K.
AU  - Plate, K.H.*
C1  - 22295
C2  - 21100
SP  - 709-717
TI  - Participation of Bone Marrow-Derived Cells in Long-Term Repair Processes After Experimental  Stroke.
JO  - J. Cereb. Blood Flow Metab.
VL  - 23
PY  - 2003
SN  - 0271-678X
ER  - 

TY  - JOUR
AU  - Stevens, S.L.*
AU  - Shaw, T.E.*
AU  - Dykhuizen, E.*
AU  - Lessov, N.S.*
AU  - Hill, J.K.*
AU  - Wurst, W.
AU  - Stenzel-Poore, M.P.*
C1  - 10103
C2  - 21498
SP  - 1151-1159
TI  - Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia : A potential link to microglia and atrocytes that express CRH-R1.
JO  - J. Cereb. Blood Flow Metab.
VL  - 23
PY  - 2003
SN  - 0271-678X
ER  -