TY  - JOUR
AB  - The original version of this article contained an error. The first and last names of the authors were interchanged. The original article has been corrected.
AU  - Atasoy, S.
AU  - Middeke, M.*
AU  - Johar, H.
AU  - Peters, A.
AU  - Heier, M.
AU  - Ladwig, K.H.*
C1  - 67251
C2  - 54193
TI  - Correction to: Cardiovascular mortality risk in young adults with isolated systolic hypertension: Findings from population-based MONICA/KORA cohort study.
JO  - J. Hum. Hypertens.
VL  - 37
IS  - 4
PY  - 2023
SN  - 0950-9240
ER  - 

TY  - JOUR
AB  - The clinical significance of isolated systolic hypertension in young adults (ISHY) remains a topic of debate due to evidence ISHY could be a spurious condition resulting from exageratted pulse pressure amplification in "young tall men with elastic arteries". Hence, we aimed to investigate whether ISHY is associated with an increased risk of cardivascular (CVD) mortality in a sample of 5597 young adults (49.8% men, 50.2% women) between 25 and 45 years old from the prospective population-based MONICA/KORA cohort. ISHY was prevalent in 5.2% of the population, affecting mostly men (73.1%), and associated with increased smoking, obesity, and hypercholesterolemia in comparison to participants with normal blood pressure (BP). Within a follow-up period of 25.3 years (SD ± 5.2; 141,768 person-years), 133(2.4%) CVD mortality cases were observed. Participants with ISHY had a hazard ratio (HR) of 1.89(1.01-3.53, p < 0.05) times higher risk of CVD mortality than participants with normal BP, even following adjustment for CVD risk factors. However, adjustment for antihypertensive medication (HR 0.46; 0.26-0.81, p < 0.001) and increasing height (HR 0.96; 0.93-0.99, p < 0.05) revealed independently protective effects against CVD mortality, suggesting that although ISHY is associated with an increased risk of CVD mortality, the protective effects of increasing height or antihypertensive medication should be considered in treatment rationale.
AU  - Atasoy, S.
AU  - Middeke, M.*
AU  - Johar, H.
AU  - Peters, A.
AU  - Heier, M.
AU  - Ladwig, K.-H.*
C1  - 63264
C2  - 49956
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Cardiovascular mortality risk in young adults with isolated systolic hypertension: Findings from population-based MONICA/KORA cohort study.
JO  - J. Hum. Hypertens.
PB  - Springernature
PY  - 2021
SN  - 0950-9240
ER  - 

TY  - JOUR
AB  - An amendment to this paper has been published and can be accessed via a link at the top of the paper.
AU  - Gonzalez-Jaramillo, V.*
AU  - Portilla-Fernandez, E.*
AU  - Glisic, M.*
AU  - Voortman, T.*
AU  - Bramer, W.*
AU  - Chowdhury, R.*
AU  - Roks, A.J.M.*
AU  - Danser, A.H.J.*
AU  - Muka, T.*
AU  - Nano, J.
AU  - Franco, O.H.*
C1  - 56814
C2  - 47288
CY  - Macmillan Building, 4 Crinan St, London N1 9xw, England
SP  - 193-193
TI  - The role of DNA methylation and histone modifications in blood pressure: A systematic review (vol 33, pg 703, 2019).
JO  - J. Hum. Hypertens.
VL  - 34
IS  - 2
PB  - Nature Publishing Group
PY  - 2020
SN  - 0950-9240
ER  - 

TY  - JOUR
AB  - Epigenetic mechanisms might play a role in the pathophysiology of hypertension, a major risk factor for cardiovascular disease and renal failure. We aimed to systematically review studies investigating the association between epigenetic marks (global, candidate-gene or genome-wide methylation of DNA, and histone modifications) and blood pressure or hypertension. Five bibliographic databases were searched until the 7th of December 2018. Of 2984 identified references, 26 articles based on 25 unique studies met our inclusion criteria, which involved a total of 28,382 participants. The five studies that assessed global DNA methylation generally found lower methylation levels with higher systolic blood pressure, diastolic blood pressure, and/or presence of hypertension. Eighteen candidate-gene studies reported, in total, 16 differentially methylated genes, including renin-angiotensin-system-related genes (ACE promoter and AGTR1) and genes involved in sodium homeostasis and extracellular fluid volume maintenance system (NET promoter, SCNN1A, and ADD1). Between the three identified epigenome-wide association studies (EWAS), lower methylation levels of SULF1, EHMT2, and SKOR2 were found in hypertensive patients as compared with normotensive subjects, and lower methylation levels of PHGDH, SLC7A11, and TSPAN2 were associated with higher systolic and diastolic blood pressure. In summary, the most convincing evidence has been reported from candidate-gene studies, which show reproducible epigenetic changes in the interconnected renin-angiotensin and inflammatory systems. Our study highlights gaps in the literature on the role of histone modifications in blood pressure and the need to conduct high-quality studies, in particular, hypothesis-generating studies that may help to elucidate new molecular mechanisms.
AU  - Gonzalez-Jaramillo, V.*
AU  - Portilla-Fernandez, E.*
AU  - Glisic, M.*
AU  - Voortman, T.*
AU  - Bramer, W.*
AU  - Chowdhury, R.*
AU  - Roks, A.J.M.*
AU  - Jan Danser, A.H.*
AU  - Muka, T.*
AU  - Nano, J.
AU  - Franco, O.H.*
C1  - 56654
C2  - 47191
CY  - Macmillan Building, 4 Crinan St, London N1 9xw, England
SP  - 703-715
TI  - The role of DNA methylation and histone modifications in blood pressure: A systematic review.
JO  - J. Hum. Hypertens.
VL  - 33
IS  - 10
PB  - Nature Publishing Group
PY  - 2019
SN  - 0950-9240
ER  - 

TY  - JOUR
AU  - Padmanabhan, S.*
AU  - Menni, C.*
AU  - Alsanosi, S.*
AU  - Kastenmüller, G.
AU  - McBride, M.*
AU  - Mangino, M.*
AU  - Brosnan, J.*
AU  - Trimmer, J.*
AU  - Mohney, R.P.*
AU  - Suhre, K.
AU  - Gieger, C.
AU  - Melander, O.*
AU  - Dominiczak, A.*
AU  - Spector, T.*
AU  - Valdes, A.*
C1  - 32525
C2  - 35123
CY  - London
SP  - 638
TI  - Circulating levels of a dicarboxylic acid associate with blood pressure, predict mortality and response to antihypertensive drugs. A multi-omics study.
JO  - J. Hum. Hypertens.
VL  - 28
IS  - 10
PB  - Nature Publishing Group
PY  - 2014
SN  - 0950-9240
ER  - 

TY  - JOUR
AU  - Kuch, B.*
AU  - von Scheidt, W.*
AU  - Peter, W.*
AU  - Heier, W.
AU  - Wichmann, H.-E.
AU  - Meisinger, C.
C1  - 2914
C2  - 24272
SP  - 757-764
TI  - Influence of antihypertensive therapy and blood pressure control on left ventricular geometry and function in subjects with type II diabetes: The Augsburg diabetes famnily study.
JO  - J. Hum. Hypertens.
VL  - 20
PY  - 2006
SN  - 0950-9240
ER  - 

TY  - JOUR
AU  - Metzger, M.-H.
AU  - Engel, S.
AU  - Hengstenberg, C.*
AU  - Schneider, A.E.
AU  - Stieber, J.
AU  - Döring, A.
AU  - Thorand, B.
AU  - Holmer, S.*
AU  - Löwel, H.
C1  - 22095
C2  - 20751
SP  - 67-74
TI  - Do siblings of myocardial infarction patients have specific management of hypertension ?.
JO  - J. Hum. Hypertens.
VL  - 16
PY  - 2002
SN  - 0950-9240
ER  - 

TY  - JOUR
AU  - Gasse, C.*
AU  - Hense, H.-W.*
AU  - Stieber, J.
AU  - Döring, A.
AU  - Liese, A.D.*
AU  - Keil, U.*
C1  - 21684
C2  - 19871
SP  - 27-36
TI  - Assessing hypertension management in the community : Trends of prevalence, detection, treatment and control of hypertension in the MONICA Project, Augsburg 1984-1995.
JO  - J. Hum. Hypertens.
VL  - 15
PY  - 2001
SN  - 0950-9240
ER  -