TY  - JOUR
AB  - Diabetes affects an increasing number of patients worldwide and is responsible for a significant rise in healthcare expenses. Imaging of β-cells in vivo is expected to contribute to an improved understanding of the underlying pathophysiology, improved diagnosis, and development of new treatment options for diabetes. Here, we describe the first radiosyntheses of [(3) H]-TAK875 and [(18) F]-TAK875 derivatives to be used as β-cell imaging probes addressing the free fatty acid receptor 1 (FFAR1/GPR40). The fluorine-labeled derivative showed similar agonistic activity as TAK875 in a functional assay. The radiosynthesis of the (18) F-labelled tracer 2a was achieved with 16.7 ± 5.7% radiochemical yield in a total synthesis time of 60-70 min.
AU  - Bertrand, R.*
AU  - Hamp, I.*
AU  - Brönstrup, M.*
AU  - Weck, R.*
AU  - Lukacevic, M.*
AU  - Polyak, A.*
AU  - Ross, T.L.*
AU  - Gotthardt, M.*
AU  - Plettenburg, O.
AU  - Derdau, V.*
C1  - 49391
C2  - 41817
CY  - Hoboken
SP  - 604-610
TI  - Synthesis of GPR40 targeting 3H- and 18F-probes towards selective beta cell imaging.
JO  - J. Labelled Comp. Radiopharm.
VL  - 59
IS  - 14
PB  - Wiley-blackwell
PY  - 2016
SN  - 0362-4803
ER  - 

TY  - JOUR
AU  - Notni, J.*
AU  - Hofmann, F.*
AU  - Steiger, K.
AU  - Reich, D.*
AU  - Kapp, T.G.*
AU  - Rechenmacher, F.*
AU  - Kessler, H.*
AU  - Oswald, F.*
AU  - Wester, H.-J.*
C1  - 48070
C2  - 39886
CY  - Hoboken
SP  - S65
TI  - Variation of specific activities of Ga-68-Aquibeprin and Ga-68-Avebetrin enables selective PET-imaging of different alpha(5)beta(1)- und alpha(v)beta(3)-integrin expression densities.
JO  - J. Labelled Comp. Radiopharm.
VL  - 58
PB  - Wiley-blackwell
PY  - 2015
SN  - 0362-4803
ER  - 

TY  - JOUR
AU  - Matucha, M.*
AU  - Gryndler, M.*
AU  - Forczek, S.T.*
AU  - Schröder, P.
AU  - Bastviken, D.*
AU  - Rohlenova, J.*
AU  - Uhlíová, H.*
AU  - Fuksová, K.*
C1  - 2777
C2  - 24715
SP  - 437-439
TI  - A chlorine-36 and carbon-14 study of the role of chlorine in the forest ecosystem.
JO  - J. Labelled Comp. Radiopharm.
VL  - 50
IS  - 5-6
PB  - Wiley-Blackwell
PY  - 2007
SN  - 0362-4803
ER  - 

TY  - JOUR
AB  - Ring-C-14-labelled 4(3'-, 6'-, dimethyl-3'-,heptyl)-phenol (NP), an isomer of paranonyl phenol was synthesized for use in aquatic toxicity and metabolism studies. A very efficient method involving alkylation of ring-C-14-labeled anisole and tertiary alkyl bromide (3-bromo-3,6-dimethyl heptane) with AlCl3 followed by cleavage of the resultant ether with BBr3 was used giving a 24% yield ring labelled C-14-NP (specific activity: 16.205 MBq/mg and purity > 95% by HPLC) after TLC separation.
AU  - Lalah, J.O.*
AU  - Lenoir, D.
AU  - Henkelmann, B.
AU  - Hertkorn, N.
AU  - Günther, K.*
AU  - Schramm, K.-W.
AU  - Kettrup, A.
C1  - 10068
C2  - 19817
SP  - 459-463
TI  - Synthesis of ring-14C-labelled 4(3'-,6'-dimethyl-3'-heptyl)-phenol.
JO  - J. Labelled Comp. Radiopharm.
VL  - 44 
IS  - 6
PB  - Wiley
PY  - 2001
SN  - 0362-4803
ER  - 

TY  - JOUR
AB  - The synthesis of 3-chloro-4-methyl-[4-14C]-7-hydroxycoumarin from ethyl [3-14C] acetoacetat is described. The overall radiochemical yield was 46%, after prufication, at a specific activity of 5 mCi/mol.
AU  - Mueller, J.P.H.
AU  - Attar, A.
AU  - Kurth, H.J.
AU  - Bieniek, D.
C1  - 40940
C2  - 38289
SP  - 261-264
TI  - Synthese von 3-Chlor-4-Methyl- [4-14C] - 7- Hydroxycumarin.
JO  - J. Labelled Comp. Radiopharm.
VL  - VOL. 15
PY  - 1978
SN  - 0362-4803
ER  - 

TY  - JOUR
AB  - The preparation of pentachlorobenzene-14C from pentachloronitrobenzene via pentachloroaniline for metabolic studies in animals is described. The overall radiochemical yield, after purification, was 68% at a specific activity of 5 mCi/mmol. The chemical purity of 99% was established.
AU  - Mueller, J.P.H.
AU  - Attar, A.
AU  - Kurth, H.J.
AU  - Bieniek, D.
C1  - 42526
C2  - 35743
SP  - 499-502
TI  - Synthese von Pentachlorbenzol-14C.
JO  - J. Labelled Comp. Radiopharm.
VL  - 15
PY  - 1978
SN  - 0362-4803
ER  - 

TY  - JOUR
AB  - Upon the reaction of benzene-14C via nitrobenzene-14C and aniline-14C, some 14C-labelled environmental contaminants were were synthesized. By chlorination of aniline-14C and acetanilide-14C the authors prepared chloroanilines-14C. Gomberg-Bachmann or Cadogan reaction of diazotated chloroanilines-14C with different chlorobenzenes gave di, tri- and pentachlorobiphenyls-14C. By boiling anilinediazonium sulfate-14C the authors prepared phenol-14C, which was chlorinated to give 2,4,6-trichlorophenol-14C. Hexachlorobenzene-14C and pentachloronitrobenzene-14C were prepared by chlorination of nitrobenzene- 14C. Chloralkylene 9-14C was synthesized by Friedel-Crafts alkylation of 2,4'-dichlorobiphenyl-14C with 2-chloropropane.
AU  - Sandrock, K.
AU  - Attar, A.
AU  - Bieniek, D.
C1  - 40966
C2  - 38520
SP  - 197-204
TI  - Synthese 14C-markierter Umweltchemikalen.
JO  - J. Labelled Comp. Radiopharm.
VL  - 14
IS  - 2
PY  - 1978
SN  - 0362-4803
ER  -