PuSH - HMGU Publikationen https://push-zb.helmholtz-munich.de PuSH - Publikationen-Server des Helmholtz Zentrums München de-de <![CDATA[Joseph, E.K.* et al. Design, synthesis and preclinical evaluation of a brain-permeable PET tracer for P2Y12 receptor imaging in the brain. J. Med. Chem. 68, 15543-15562 (2025)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=75248&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=75248&la=de Tue, 29 Jul 2025 00:00:00 +0000 <![CDATA[Falke, S.* et al. Structural elucidation and antiviral activity of covalent cathepsin L inhibitors. J. Med. Chem. 67, 7048-7067 (2024)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=70540&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=70540&la=de Wed, 05 Jun 2024 00:00:00 +0000 <![CDATA[Grygier, P.* et al. Silmitasertib (CX-4945), a clinically used CK2-kinase inhibitor with additional effects on GSK3β and DYRK1A kinases: A structural perspective. J. Med. Chem. 66, 4009-4024 (2023)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67752&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67752&la=de Fri, 06 Oct 2023 00:00:00 +0000 <![CDATA[Kitel, R.* et al. Discovery of inhibitory fragments that selectively target spire2-FMN2 interaction. J. Med. Chem. 66, 15715-15727 (2023)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=68881&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=68881&la=de Fri, 15 Dec 2023 00:00:00 +0000 <![CDATA[Narayanan, D.* et al. Development of noncovalent small-molecule Keap1-Nrf2 inhibitors by fragment-based drug discovery. J. Med. Chem. 65, 14481-14526 (2022)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=66474&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=66474&la=de Fri, 25 Nov 2022 00:00:00 +0000 <![CDATA[Hofmeister, A.* et al. Syntheses of morpholine-based nucleotide analogs for hepatic siRNA targeting and stabilization. J. Med. Chem. 64, 6838–6855 (2021)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=61939&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=61939&la=de Mon, 14 Jun 2021 00:00:00 +0000 <![CDATA[Pallesen, J.S.* et al. Deconstructing noncovalent kelch-like ECH-associated protein 1 (Keap1) inhibitors into fragments to reconstruct new potent compounds. J. Med. Chem. 64, 4623-4661 (2021)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=61730&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=61730&la=de Tue, 25 May 2021 00:00:00 +0000 <![CDATA[Dawidowski, M. et al. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity. J. Med. Chem. 63, 847-879 (2020)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=57992&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=57992&la=de Mon, 03 Feb 2020 00:00:00 +0000 <![CDATA[Hanke, S.* et al. Structural studies on the inhibitory binding mode of aromatic coumarinic esters to human kallikrein-related peptidase 7. J. Med. Chem. 63, 5723-5733 (2020)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=59030&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=59030&la=de Thu, 07 May 2020 00:00:00 +0000 <![CDATA[Solbak, S.M.* et al. Developing inhibitors of the p47phox-p22phox protein-protein interaction by fragment-based drug discovery. J. Med. Chem. 63, 1156-1177 (2020)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=57833&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=57833&la=de Thu, 16 Jan 2020 00:00:00 +0000 <![CDATA[van de Plassche, M.A.T.* et al. Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe. J. Med. Chem. 63, 3996-4004 (2020)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=59180&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=59180&la=de Mon, 25 May 2020 00:00:00 +0000 <![CDATA[Li, C.* et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4. J. Med. Chem. 62, 266-275 (2019)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=55202&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=55202&la=de Fri, 18 Jan 2019 00:00:00 +0000 <![CDATA[Guarino, C.* et al. Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis. J. Med. Chem. 61, 1858-1870 (2018)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=53276&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=53276&la=de Tue, 20 Mar 2018 00:00:00 +0000 <![CDATA[Kyriakou, E. et al. Celastrol promotes weight loss in diet-induced obesity by inhibiting the protein tyrosine phosphatases PTP1B and TCPTP in the hypothalamus. J. Med. Chem. 61, 11144-11157 (2018)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=54937&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=54937&la=de Thu, 20 Dec 2018 00:00:00 +0000 <![CDATA[Bertoletti, N.* et al. New insights into human 17β-hydroxysteroid dehydrogenase type 14: First crystal structures in complex with a steroidal ligand and with a potent non-steroidal inhibitor. J. Med. Chem. 59, 6961-6967 (2016)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=48993&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=48993&la=de Sat, 09 Jul 2016 00:00:00 +0000 <![CDATA[Braun, F.* et al. First structure-activity relationship of 17β-hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme. J. Med. Chem. 59, 10719-10737 (2016)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50170&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50170&la=de Fri, 23 Dec 2016 00:00:00 +0000 <![CDATA[Jagtap, P.K. et al. Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. J. Med. Chem. 59, 10190-10197 (2016)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50098&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50098&la=de Sat, 31 Dec 2016 00:00:00 +0000 <![CDATA[Gilsbach, B.K.* et al. Structural characterization of LRRK2 inhibitors. J. Med. Chem. 58, 3751-3756 (2015)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=44966&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=44966&la=de Wed, 27 May 2015 00:00:00 +0000 <![CDATA[Marchais-Oberwinkler, S.* et al. Structural optimization of 2,5-tiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis. J. Med. Chem. 56, 167-181 (2013)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=11863&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=11863&la=de Wed, 23 Jan 2013 00:00:00 +0000 <![CDATA[Wetzel, M.* et al. Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors. J. Med. Chem. 54, 7547-7557 (2011)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=6749&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=6749&la=de Thu, 01 Dec 2011 00:00:00 +0000 <![CDATA[Garg, D. et al. Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J. Med. Chem. 53, 6539-6549 (2010)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=5133&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=5133&la=de Fri, 31 Dec 2010 00:00:00 +0000 <![CDATA[Richert, C.* et al. Photodynamic antitumor agents: β-Methoxyethyl groups give access to functionalized porphycenes and enhance cellular uptake and activity. J. Med. Chem. 37, 2797-2807 (1994)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=40038&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=40038&la=de Fri, 30 Dec 1994 00:00:00 +0000 <![CDATA[Strobl, G.R. ; Kruedener, S. von ; Stöckigt, J. ; Guengerich, F.P. & Wolff, T. Development of a Pharmacophore for Inhibition of Human Liver Cytochrome P-450 2D6: Molecular Modeling and Inhibition Studies. J. Med. Chem. 36, 1136-1145 (1993)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=20329&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=20329&la=de Fri, 31 Dec 1993 00:00:00 +0000 <![CDATA[Strobl, G.R. ; von Kruedener, S.* ; Stöckigt, J.H.H.* ; Guengerich, F.P.* & Wolff, T. Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modeling and inhibition studies. J. Med. Chem. 36, 1136-1145 (1993)]]> https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=40385&la=de https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=40385&la=de Thu, 11 Nov 1993 00:00:00 +0000