TY  - JOUR
AB  - Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45+ immune cells were found to be depleted in sciatic nerve (SN) and DRG in mice, prior to hyperglycemia. Macrophages were also lost in DRG and NFκB-p65-activation was increased in SN macrophages. Immune cells were significantly reduced in both SN and DRG up to three weeks, post-treatment. Loss of PNS-resident macrophages in response to STZ-mediated toxicity may affect the regenerative capacity of the nerve in response to further injury caused by diabetes.
AU  - Hidmark, A.S.*
AU  - Nawroth, P.P.
AU  - Fleming, T.*
C1  - 50843
C2  - 42907
CY  - Amsterdam
SP  - 76-82
TI  - STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.
JO  - J. Neuroimmunol.
VL  - 306
PB  - Elsevier Science Bv
PY  - 2017
SN  - 0165-5728
ER  - 

TY  - JOUR
AU  - Berer, K.*
AU  - Martinez, I.*
AU  - Walker, A.
AU  - Schmitt-Kopplin, P.
AU  - Walter, J.*
AU  - Wekerle, H.*
AU  - Krishnamoorthy, G.*
C1  - 43000
C2  - 35938
SP  - 95-96
TI  - Impact of dietary metabolism by gut microbiota on the pathogenesis of spontaneous autoimmune encephalomyelitis.
JO  - J. Neuroimmunol.
VL  - 275
IS  - 1-2
PY  - 2014
SN  - 0165-5728
ER  - 

TY  - JOUR
AU  - Hoffmann, F.*
AU  - Kühn, P.*
AU  - Laurent, S.A.*
AU  - Hauck, S.M.
AU  - Berer, K.*
AU  - Krumbholz, M.*
AU  - Khademi, M.*
AU  - Olsson, T.*
AU  - Dreyling, M.*
AU  - Pfister, H.*
AU  - Alexander, T.*
AU  - Hiepe, F.*
AU  - Kuempfel, T.*
AU  - Crawford, H.C.*
AU  - Wekerle, H.*
AU  - Hohlfeld, R.*
AU  - Lichtenthaler, S.F.*
AU  - Meinl, E.*
C1  - 42999
C2  - 35939
SP  - 5-6
TI  - ADAM10 releases the immunoregulator soluble TACI - a novel biomarker for B-cell pathologies.
JO  - J. Neuroimmunol.
VL  - 275
IS  - 1-2
PY  - 2014
SN  - 0165-5728
ER  - 

TY  - JOUR
AU  - Srivastava, R.*
AU  - Kalluri, S.R.*
AU  - Schäfer, Y.*
AU  - Krysta, A.*
AU  - Grummel, V.*
AU  - Kremmer, E.
AU  - Buck, D.*
AU  - Schirmer, L.*
AU  - Hemmer, B.*
C1  - 42998
C2  - 35940
SP  - 25
TI  - Differential glycosylation of KIR4.1 in glial cells affects binding of autoantibodies in multiple sclerosis.
JO  - J. Neuroimmunol.
VL  - 275
IS  - 1-2
PY  - 2014
SN  - 0165-5728
ER  - 

TY  - JOUR
AU  - Bergh, F.T.*
AU  - Dayyani, F.*
AU  - Ziegler-Heitbrock, L.
C1  - 3656
C2  - 22273
SP  - 176-188
TI  - Impact of type-I-interferon on monocyte subsets and their differentiation to dendritic cells: An in vivo and ex vivo study in multiple sclerosis patients treated with interferon-beta.
JO  - J. Neuroimmunol.
VL  - 146
PY  - 2004
SN  - 0165-5728
ER  - 

TY  - JOUR
AB  - Stiff-man syndrome (SMS) is a rare autoimmune disorder of the central nervous system associated with autoantibodies to glutamate decarboxylase (GAD). We isolated five brain-reactive human monoclonal antibodies, with reactivity distinct from GAD, from peripheral blood of a patient newly diagnosed with SMS. Two antibodies reacted with both Purkinje cells and ependymal cells, and precipitated an 80-kDa protein from rat neuronal primary cultures, which was also recognized by 12% (3/25) of SMS sera and 13% (2/15) of SMS cerebrospinal fluid (CSF) samples. The corresponding antigen was identified as 17beta-hydroxysteroid dehydrogenase type 4 and may represent a possible novel target of autoimmunity in SMS.
AU  - Dinkel, K.*
AU  - Rickert, M.*
AU  - Möller, G.
AU  - Adamski, J.
AU  - Meinck, H.-M.*
AU  - Richter, W.*
C1  - 10053
C2  - 20429
SP  - 184-193
TI  - Stiff-man syndrome : Identification of 17ß-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen.
JO  - J. Neuroimmunol.
VL  - 130
PB  - Elsevier Science
PY  - 2002
SN  - 0165-5728
ER  - 

TY  - JOUR
AB  - T-lymphocytes were identified in frozen brain sections derived from patients with chronic inflammatory disorders of the CNS by using a specific heteroantiserum and the unlabelled antibody enzyme method. Clusters of T-cells were found in post-mortem material of cases with multiple sclerosis (MS) and subacute sclerosing penencephalitis (SSPE). The results suggest that T-lymphocytes are involved in the pathogenesis of both MS and SSPE.
AU  - Kreth, H.W.*
AU  - Dunker, R.*
AU  - Rodt, H.V.
AU  - Meyermann, R.*
C1  - 41705
C2  - 38281
SP  - 177-183
TI  - Immunohistochemical identification of T-lymphocytes in the central nervous system of patients with multiple sclerosis and subacute sclerosing panencephalitis.
JO  - J. Neuroimmunol.
VL  - 2
IS  - 2
PY  - 1982
SN  - 0165-5728
ER  -