TY  - JOUR
AB  - As part of a project on environmental pollution, this study aimed to evaluate associations between blood lead (BPb) levels, hemoglobin (Hb) content, and single-nucleotide polymorphisms (SNPs) of delta-aminolevulinic acid dehydratase (ALAD) gene in 129 unrelated women from Romania. Five SNPs (rs1805313, rs2228083, rs1805312, rs1800435, rs1139488) were analyzed with respect to haplotype structure and impact on BPb levels and Hb content with proportional odds and analysis of covariance models. Combinations of SNPs were rare (16%). Low haplotype diversity was found with seven haplotypes. One rare haplotype implied the C allele of rs1800435, often referred to as the ALAD2 allele (frequency 8.6%). The putative risk genotype (CC) occurred in only one woman with BPb below 0.5 microg/dl. Median BPb was 4.8 microg/dl and differed markedly by community with a level of 12.5 microg/dl near a mining-spill region. Hb was regular (interquartile range 12.3-13.7 g/dl) and not correlated with BPb, although quantitatively lower in women living near the spill region. No significant associations were found for BPb or Hb with SNPs, haplotypes, or diplotypes. BPb levels were higher in this region than in populations from industrialized countries but without hematotoxic effects. An impact of ALAD2 on BPb or Hb was not seen in these women.
AU  - Rabstein, S.*
AU  - Unfried, K.*
AU  - Ranft, U.*
AU  - Illig, T.
AU  - Kolz, M.
AU  - Mambetova, C.*
AU  - Vlad, M.*
AU  - Roman, C.*
AU  - Weiss, T.*
AU  - Becker, D.*
AU  - Brüning, T*
AU  - Pesch, B.*
C1  - 3463
C2  - 25738
SP  - 716-724
TI  - Lack of association of delta-aminolevulinate dehydratase polymorphisms with blood lead levels and hemoglobin in Romanian women from a lead-contaminated region.
JO  - J. Toxicol. Environ. Health Part A
VL  - 71
IS  - 11-12
PB  - Taylor & Francis
PY  - 2008
SN  - 1528-7394
ER  - 

TY  - JOUR
AB  - PM2.5 filter samples were collected in summer 2005 at an urban background site in Augsburg, Germany. They were analyzed for polycyclic aromatic hydrocarbons (PAH) and their oxygenated derivatives (O-PAH) using gas chromatography/mass spectrometry. Oxygen free radical formation (reactive oxygen substances, ROS) was measured by electron spin resonance (ESR) spectroscopy after addition of spin trapping agent directly on the same filters. The concentrations of ambient, high-boiling PAH and O-PAH were highly correlated to ROS formation, even better than to particulate mass or number concentration. Correlations were most pronounced for some polycyclic aromatic monoketones (e.g., benz[de]anthracene-7-one), which are not yet reported in literature to be redox cycling active. The association found between ESR measurements and the presence of specific semivolatile organic compounds suggests an important influence of wood burning in PM2.5-associated ROS formation. These results indicate that further research on the relationship between radical formation and presence of specific O-PAH and semivolatile organic compounds (SVOC) are likely to provide a better understanding of the relationship between the source-dependent chemical composition of PM and the toxicological risks associated with PM exposure.
AU  - Sklorz, M.
AU  - Briedé, J.J.*
AU  - Schnelle-Kreis, J.*
AU  - Liu, Y.*
AU  - Cyrys, J.
AU  - de Kok, T.M.*
AU  - Zimmermann, R.
C1  - 2341
C2  - 24841
SP  - 1866-1869
TI  - Concentration of oxygenated polycyclic aromatic hydrocarbons and oxygen free radical formation from urban particulate matter.
JO  - J. Toxicol. Environ. Health Part A
VL  - 70
IS  - 21
PB  - Taylor & Francis
PY  - 2007
SN  - 1528-7394
ER  - 

TY  - JOUR
AU  - Heid, I.M.
AU  - Küchenhoff, H.*
AU  - Schaffrath Rosario, A.
AU  - Kreienbrock, L.*
AU  - Wichmann, H.-E.
C1  - 5585
C2  - 23789
SP  - 701-721
TI  - Impact of measurement error in exposures in German radon studies.
JO  - J. Toxicol. Environ. Health Part A
VL  - 69
PY  - 2006
SN  - 1528-7394
ER  - 

TY  - JOUR
AU  - Schaffrath Rosario, A.
AU  - Wellmann, J.
AU  - Heid, I.M.
AU  - Wichmann, H.-E.
C1  - 3907
C2  - 23695
SP  - 681-700
TI  - Radon epidemiology: Continous and catergorical trend estimators when the exposure distribution is skewed and outliers may be present.
JO  - J. Toxicol. Environ. Health Part A
VL  - 69
PY  - 2006
SN  - 1528-7394
ER  - 

TY  - JOUR
AU  - Kreyling, W.G.
AU  - Semmler, M.
AU  - Erbe, F.
AU  - Mayer, P.
AU  - Takenaka, S.
AU  - Schulz, S.
AU  - Oberdörster, G.*
AU  - Ziesenis, A.
C1  - 10028
C2  - 20676
SP  - 1513-1530
TI  - Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. 
JO  - J. Toxicol. Environ. Health Part A
VL  - 65
PY  - 2002
SN  - 1528-7394
ER  - 

TY  - JOUR
AU  - Oberdörster, G.*
AU  - Sharp, Z.*
AU  - Atudorei, V.*
AU  - Elder, A.*
AU  - Gelein, R.*
AU  - Lunts, A.*
AU  - Kreyling, W.G.
AU  - Cox, C.*
C1  - 10027
C2  - 20675
SP  - 1531-1543
TI  - Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats.
JO  - J. Toxicol. Environ. Health Part A
VL  - 65
PY  - 2002
SN  - 1528-7394
ER  - 

TY  - JOUR
AU  - Weber, L.W.D.
AU  - Greim, H.
AU  - Rozman, K.K.
C1  - 20720
C2  - 13939
SP  - 195-206
TI  - Metabolism and Distribution of (14C)Glucose in Rats Treated with 2,3,7,8,.Tetrachlorodibenzo-p- Dioxin (TCDD).
JO  - J. Toxicol. Environ. Health Part A
VL  - 22
PY  - 1987
SN  - 1528-7394
ER  -