TY  - JOUR
AB  - Cellular heterogeneity is a property of any living system; however, its relationship with cellular fate decision remains an open question. Recent technological advances have enabled valuable insights, especially in complex systems such as the mouse embryo. In this review, we discuss recent studies that characterize cellular heterogeneity at different levels during mouse development, from the two-cell stage up to gastrulation. In addition to key experimental findings, we review mathematical modeling approaches that help researchers interpret these findings. Disentangling the role of heterogeneity in cell fate decision will likely rely on the refined integration of experiments, large-scale omics data, and mathematical modeling, complemented by the use of synthetic embryos and gastruloids as promising in vitro models.
AU  - Fiorentino, J.
AU  - Torres-Padilla, M.E.
AU  - Scialdone, A.
C1  - 60676
C2  - 49585
CY  - 4139 El Camino Way, Po Box 10139, Palo Alto, Ca 94303-0897 Usa
SP  - 167-187
TI  - Measuring and modeling single-cell heterogeneity and fate decision in mouse embryos.
JO  - Annu. Rev. Genet.
VL  - 54
PB  - Annual Reviews
PY  - 2020
SN  - 0066-4197
ER  - 

TY  - JOUR
AB  - The mouse is central to the goal of establishing a comprehensive functional annotation of the mammalian genome that will help elucidate various human disease genes and pathways. The mouse offers a unique combination of attributes, including an extensive genetic toolkit that underpins the creation and analysis of models of human disease. An international effort to generate mutations for every gene in the mouse genome is a first and essential step in this endeavor. However, the greater challenge will be the determination of the phenotype of every mutant. Large-scale phenotyping for genome-wide functional annotation presents numerous scientific, infrastructural, logistical, and informatics challenges. These include the use of standardized approaches to phenotyping procedures for the population of unified databases with comparable data sets. The ultimate goal is a comprehensive database of molecular interventions that allows us to create a framework for biological systems analysis in the mouse on which human biology and disease networks can be revealed.
AU  - Brown, S.D.*
AU  - Wurst, W.
AU  - Kühn, R.
AU  - Hancock, J.M.*
C1  - 974
C2  - 26701
CY  - USA
SP  - 305-333
TI  - The functional annotation of mammalian genomes: The challenge of phenotyping.
JO  - Annu. Rev. Genet.
VL  - 43
PB  - Annual Reviews
PY  - 2009
SN  - 0066-4197
ER  - 

TY  - JOUR
AU  - Favor, J.
AU  - Neuhäuser-Klaus, A.
C1  - 40007
C2  - 40088
SP  - 27-47
TI  - Genetic mosaicism in the house mouse.
JO  - Annu. Rev. Genet.
VL  - 28
PY  - 1994
SN  - 0066-4197
ER  - 

TY  - JOUR
AU  - Ehling, U.H.
C1  - 33301
C2  - 40257
SP  - 255-280
TI  - Genetic risk assessment.
JO  - Annu. Rev. Genet.
VL  - 25
PY  - 1991
SN  - 0066-4197
ER  -