TY  - JOUR
AU  - van der Garde, M.*
AU  - Thomas, M.
AU  - Riviere, J.*
AU  - Figueredo, A.N.*
AU  - Hecker, J.*
AU  - Metzeler, K.*
AU  - Marr, C.
AU  - Goetze, K.*
C1  - 69409
C2  - 55100
CY  - The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
TI  - Multiomic analysis of chip bone marrow hematopoietic stem/progenitor cells reveals potential early stage of malignancy.
JO  - Leuk. Res.
VL  - 128
PB  - Pergamon-elsevier Science Ltd
PY  - 2023
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Cyclic cytotoxic maintenance therapy can be applied to patients with AML in post-remission. We studied the immune status of AML patients in complete remission and the effect of maintenance therapy on different immune cell populations. Patients in complete remission had reduced NK, TH and Treg counts and a reduced NK activation capacity. In the course of cytotoxic maintenance therapy, NK counts further declined, while TH and Treg cells increased, with lower proliferative potential of TH cells. We conclude that immunotherapeutic approaches in post-remission have to consider reduced NK cell function and further impairment of cellular immune responses during cytotoxic therapy.
AU  - Lichtenegger, F.S.
AU  - Lorenz, R.
AU  - Gellhaus, K.*
AU  - Hiddemann, W.
AU  - Beck, B.
AU  - Subklewe, M.
C1  - 31671
C2  - 34740
SP  - 964-969
TI  - Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML.
JO  - Leuk. Res.
VL  - 38
IS  - 8
PY  - 2014
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - The alkylphosphocholine (APC) erufosine is a synthetic phospholipid analogue with antineoplastic activity. APC are known to interact with lipid metabolism and modulate cellular signaling pathways, particularly the phosphorylation of Akt. Here, in primary CLL cells induction of apoptosis was detected with an IC50 of 22muM whereas healthy donor PBMC were less sensitive towards erufosine. Treatment with erufosine caused dose-dependent cleavage of PARP, co-incubation with caspase inhibitor z-VAD almost completely abrogated the cytotoxic effect of erufosine indicating a caspase-dependent mechanism of erufosine. Erufosine was shown to induce apoptosis in primary CLL cells and merits further investigation regarding therapeutic options in CLL.
AU  - Königs, S.K.*
AU  - Pallasch, C.P.*
AU  - Lindner, L.H.
AU  - Schwamb, J.*
AU  - Schulz, A.*
AU  - Brinker, R.*
AU  - Claasen, J.*
AU  - Veldurthy, A.*
AU  - Eibl, H.*
AU  - Hallek, M.*
AU  - Wendtner, C.M.*
C1  - 5553
C2  - 28190
SP  - 1064-1069
TI  - Erufosine, a novel alkylphosphocholine, induces apoptosis in CLL through a caspase-dependent pathway.
JO  - Leuk. Res.
VL  - 34
IS  - 8
PB  - Elsevier
PY  - 2010
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.
AU  - Gross, C.*
AU  - Holler, E.*
AU  - Stangl, S.
AU  - Dickinson, A.*
AU  - Pockley, A.G.
AU  - Asea, A.A.*
AU  - Mallappa, N.*
AU  - Multhoff, G.
C1  - 3205
C2  - 25151
SP  - 527-537
TI  - An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.
JO  - Leuk. Res.
VL  - 32
IS  - 4
PB  - Elsevier
PY  - 2008
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Multiple myeloma (MM) frequently shows overexpression of cyclin D1, either due to a t(11;14)(q13;q32) translocation, or in association with polysomy 11. The predominant expression of a cyclin D1 mRNA isoform lacking the 3'-untranslated region (Delta3'UTR) is associated with higher total cyclin D1 mRNA levels, increased proliferation and poor prognosis in mantle cell lymphoma, and can be caused by genetic alterations of the 3'UTR region. The role of this cyclin D1 isoform in MM is unknown. We therefore quantified levels of total and Delta3'UTR cyclin D1 mRNA by real-time RT-PCR in cytogenetically characterized cyclin D1+MM primary cases, and cyclin D1+cell lines. Both long and Delta3'UTR cyclin D1 transcripts were expressed in 35/41 MM cases, but none of the samples showed complete loss of the long transcript or genomic alterations of the 3'UTR. Predominance of the Delta3'UTR mRNA was associated with higher cyclin D1 levels in cases with t(11;14), but did not correlate with the proliferation rate, suggesting a different role of this isoform in MM.
AU  - Slotta-Huspenina, J.*
AU  - Koch, I.*
AU  - Richter, M.
AU  - Bink, K.
AU  - Kremer, M.*
AU  - Specht, K.*
AU  - Krugmann, J.
AU  - Quintanilla-Martinez, L.
AU  - Fend, F.*
C1  - 729
C2  - 25118
SP  - 79-88
TI  - Cyclin D1 positive multiple myeloma: Predominance of the short, 3'UTR-deficient transcript is associated with high cyclin D1 mRNA levels in cases with t(11;14) translocation, but does not correlate with proliferation rate or genomic deletions.
JO  - Leuk. Res.
VL  - 32
IS  - 1
PB  - Elsevier
PY  - 2008
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - The classification, scoring systems, and response criteria for myelodysplastic syndromes (MDS) have recently been updated and have become widely accepted. In addition, several new effective targeted drugs for patients with MDS have been developed. The current article provides a summary of updated and newly proposed markers, criteria, and standards in MDS, with special reference to the diagnostic interface and refinements in evaluations and scoring. Concerning the diagnostic interface, minimal diagnostic criteria for MDS are proposed, and for patients with unexplained cytopenia who do not fulfill these criteria, the term ‘idiopathic cytopenia of uncertain significance’ (ICUS)next term is suggested. In addition, new diagnostic and prognostic parameters, histopathologic and immunologic determinants, proposed refinements in scoring systems, and new therapeutic approaches are discussed. Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials.
AU  - Valent, P.*
AU  - Horny, H.-P.*
AU  - Bennett, J.M.*
AU  - Fonatsch, C.*
AU  - Germing, U.*
AU  - Greenberg, P.*
AU  - Haferlach, T.*
AU  - Haase, D.*
AU  - Kolb, H.-J.
AU  - Krieger, O.*
AU  - Loken, M.*
AU  - van de Loosdrecht, A.*
AU  - Ogata, K.*
AU  - Orfao, A.*
AU  - Pfeilstöcker, M.*
AU  - Rüter, B.*
AU  - Sperr, W.R.*
AU  - Stauder, R.*
AU  - Wells, D.A.*
C1  - 4233
C2  - 24952
SP  - 727-736
TI  - Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference.
JO  - Leuk. Res.
VL  - 31
IS  - 6
PB  - Elsevier
PY  - 2007
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - We describe a patient with fever and multiple osteolytic bone lesions accompanied by hypercalcemia, a duodenal ulcer, anemia, and thrombocytopenia. Bone marrow showed a dense infiltration by abnormal cells characterized by small basophil granula, erythrophagocytosis and nuclear atypia. These cells were positive for toluidine blue and partly for myeloperoxidase and chloroacetate esterase, expressed myeloid differentiation markers, and exhibited multiple numerical and structural chromosome aberrations. Molecular genetic analysis showed no breakpoint cluster region rearrangement. Electron microscopy demonstrated granula both of basophil and mast cell type. Concluding, in this patient an acute hematopoietic malignancy with many features of malignant mastocytosis but also with signs of a basophil differentiation. This is further support for a hematopoietic stem cell origin of human mast cells.
AU  - Mezger, J.
AU  - Permanetter, W.*
AU  - Gerhartz, H.H.*
AU  - Bartl, R.
AU  - Bauchinger, M.
AU  - Schmetzer, H.M.*
AU  - Sauer, H.W.*
C1  - 41902
C2  - 36461
SP  - 169-175
TI  - Philadelphia chromosome-negative acute hematopoietic malignancy: Ultrastructural, cytochemical and immunocytochemical evidence of mast cell and basophil differentiation.
JO  - Leuk. Res.
VL  - 14
IS  - 2
PY  - 1990
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Female C57BL/6 and BALB/c mice were injected i.p. with 0.06 microCi/kg or 0.5 microCi/kg of the short-lived alpha-emitting radionuclide 224radium at 3-day intervals. Infectious N-ecotropic XC+, and xenotropic C-type retroviruses were activated in several tissues in both strains. In C57BL/6 mice the activation of ecotropic and xenotropic virus was dose-dependent as observed 4 weeks after the start of irradiation. In BALB/c mice a few animals showed activation of ecotropic virus after four weeks of irradiation. The expression of xenotropic virus was similar in irradiated mice and controls. Viral antigen, indicative for viraemia, was not detected in irradiated or control animals. Antiviral antibodies were found in both control and irradiated mice but higher titers were found in the irradiated mice. Bone tissue-derived N-tropic XC+ virus isolates were found to be non-oncogenic in newborn mice of the parental strain. In contrast, the same virus isolates induced a novel pattern of disease, such as osteopetrosis and osteomas together with malignant lymphomas in NMRI mice. The data indicate that the pattern of endogenous murine leukemia virus activation by internal alpha-irradiation is dependent on the dose rate, and on the genetics of the mouse strain.
AU  - Schmidt, J.
AU  - Luz, A.
AU  - Erfle, V.
C1  - 27594
C2  - 32757
SP  - 393-403
TI  - Endogenous murine leukemia viruses: frequency of radiation-activation and novel pathogenic effects of viral isolates.
JO  - Leuk. Res.
VL  - 12
IS  - 5
PB  - Pergamon
PY  - 1988
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - The activation of endogenous retroviruses (MuLV) by internal irradiation and the presence of activated retroviruses in radiation-induced murine osteosarcomas as well as their biological properties in vivo and in vitro were studied. Ecotropic and xenotropic MuLV were expressed dependent on the radiation dose in spleen, bone marrow and bone tissues of C57Bl/6 mice after 224Ra treatment. Radiation-induced osteosarcomas of BALB/c, C57Bl/6 and C3H X 101/F1 mice harboured infectious ecotropic and/or xenotropic viruses whereas in osteosarcomas of NMRI mice predominantly virus protein could be detected. In about 50% of the radiation-induced osteosarcomas of BALB/c mice an amplification of ecotropic proviruses could be detected. This was not found in clonally grown cells from non-tumorous tissues. MuLV from radiation-induced osteosarcomas induced osteopetrosis, osteomas and lymphomas after infection of newborn NMRI mice. In differentiating bone tissue the viruses were found to infect predominantly osteoblast precursor cells suggesting that virus infection results in increased growth and metabolic activity of these cells, which may be a possible mechanism for their pathogenic action in bone tissues.
AU  - Erfle, V.
AU  - Schmidt, J.
AU  - Strauss, G.P.
AU  - Hehlmann, R.*
AU  - Luz, A.
C1  - 27592
C2  - 0
SP  - 905-913
TI  - Activation and biological properties of endogenous retroviruses in radiation osteosarcomagenesis.
JO  - Leuk. Res.
VL  - 10
IS  - 7
PB  - Pergamon
PY  - 1986
SN  - 0145-2126
ER  - 

TY  - JOUR
AU  - Erfle, V.
C1  - 42719
C2  - 36455
SP  - 934
TI  - Radiation-induced osteosarcomas.
JO  - Leuk. Res.
VL  - 10
IS  - 7
PY  - 1986
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - The activation of endogenous retroviruses (MuLV) by internal irradiation and the presence of activated retroviruses in radiation-induced murine osteosarcomas as well as their biological properties in vivo and in vitro were studied. Ecotropic and xenotropic MuLV were expressed dependent on the radiation dose in spleen, bone marrow and bone tissues of C57B1/6 mice after 224Ra treatment. Radiation-induced osteosarcomas of BALB/c, C57B1/6 and C3H × 101/F1 mice harboured infectious ecotropic and/or xenotropic viruses whereas in osteosarcomas of NMRI mice predominantly virus protein could be detected. In about 50% of the radiation-induced osteosarcomas of BALB/c mice an amplification of ecotropic proviruses could be detected. This was not found in clonally grown cells from non-tumorous tissues. MuLV from radiation-induced osteosarcomas induced osteopetrosis, osteomas and lymphomas after infection of newborn NMRI mice. In differentiating bone tissue the viruses were found to infect predominantly osteoblast precursor cells suggesting that virus infection results in increased growth and metabolic activity of these cells, which may be a possible mechanism for their pathogenic action in bone tissues.
AU  - Erfle, V.F.
AU  - Schmidt, J.
AU  - Strauss, G.P.
AU  - Hehlmann., R.*
AU  - Luz, A.
C1  - 42223
C2  - 38384
SP  - 905-913
TI  - Activation and biological properties of endogenous retroviruses in radiation osteosarcomagenesis.
JO  - Leuk. Res.
VL  - 10
IS  - 7
PY  - 1986
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - TdT as an intranuclear enzyme mainly of immature lymphoid cells is commonly determined immunologically using air-dried cell smears fixed with methanol. Both cell dehydration and alcohol fixation were found here to denature TdT and surface antigens. This could be prevented by using non-dehydrated cells bound electrostatically to poly-L-lysine-coated slides, fixed minimally with glutaraldehyde and rendered permeable to antibodies by the non-ionic detergent Brij 56. Crosslinking glutaraldehyde in addition prevented diffusion of TdT to extranuclear sites. By avoiding artifacts of denaturation and diffusion, a higher sensitivity in the detection of TdT was achieved despite considerably lower quantities of antibody.
AU  - Kranz, B.R.
AU  - Thierfelder, S.S.
C1  - 41695
C2  - 38375
SP  - 1041-1049
TI  - Improved detection of terminal transferase (TdT): The use of detergents on glutaraldehyde-fixed non-dehydrated cells prevents denaturation and diffusion artifacts.
JO  - Leuk. Res.
VL  - 10
IS  - 8
PY  - 1986
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - In two untreated patients with progressive CLL, quantitative 14C autoradiography of lymph nodes and, subsequently, continuous infusion of [3H] thymidine over eight and nine days, respectively, were performed in order to analyse the lymph node cell kinetics. Simultaneously, the turnover of labelled lymphocytes in the peripheral blood was evaluated. From another CLL patient a regional lymph node was removed 6 h after an intralymphatic flash injection of [3H] thymidine and sectioned for autoradiographic study of the distribution of labelled cells within the lymph node tissue. While the durations of DNA synthesis were found to be normal, the labelling indices were reduced. The relative cell production rate was far lower than normal. Very small growth fractions were calculated, amounting to less than 1% in one patient, and to 2.4% in the other. The distribution of labelled cells in the lymph nodes was focal, which supports the finding of low growth fractions. According to the present data, CLL is a disorder in which a very small number of cells cycle at a roughly normal rate. A kinetic definition of accumulative and proliferative tumour growth is introduced. Tumour growth is termed accumulative if growth appears to result from a decreased relative cell loss rate rather than an increased relative cell production rate. According to this definition, the kinetics in CLL may be classified as accumulative. In absolute terms, however, the number of lymphoid cells produced per unit of time was found to be far higher in CLL than in the healthy state.
AU  - Dörmér, P.G.
AU  - Theml, H.K.*
AU  - Lau, B.
C1  - 33148
C2  - 38600
SP  - 1-10
TI  - Chronic lymphocytic leukemia: A proliferative or accumulative disorder?.
JO  - Leuk. Res.
VL  - 7
IS  - 1
PY  - 1983
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Anatomical distribution of common acute lymphoblastic leukemia antigen (CALLA) was studied in lymphomas as well as in normal lymphatic organs using the monoclonal antibody VIL-A1. Twelve lymphomas were labelled by VIL-A1. Three of the 12 tumours also had T-cell marker, six lymphomas also showed immunoglobulin staining and only three tumours were pure CALLA lymphomas. Tonsils showed a distinct CALLA labelling of many germinal centre cells and of singular cells in interfollicular T-cell regions. Children's thymuses showed rare distinctly labelled cells in the cortex and medulla and slightly more cortical cells stained faintly by VIL-A1. Foetal thymuses of about the twelfth week of gestation contained many heavily labelled cells. The findings are discussed as evidence for the presence of CALLA on immature B as well as T lymphocytes. They favour the idea of CALLA as a common lymphocyte differentiation antigen although other possibilities of interpretation are also discussed.
AU  - Hoffman Fezer, G.
AU  - Knapp, W.H.
AU  - Thierfelder, S.S.
C1  - 40915
C2  - 38862
SP  - 761-767
TI  - Anatomical distribution of CALL antigen expressing cells in normal lymphatic tissue and in lymphomas.
JO  - Leuk. Res.
VL  - 6
IS  - 6
PY  - 1982
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - In PHA cultures of peripheral lymphocytes from three healthy donors the extent and time sequence of cALL and TdT positivity was followed over a period of seven days. In all cases significant percentages of cALL + and TdT + cells were observed. However, the period of positivity for both these markers tended to be short. In contrast to previous results with the diffusion chamber system which yielded a comparatively uniform pattern of positivity, PHA cultures of the present cases revealed a more heterogeneous pattern concerning the extent as well as the time sequence of positivity. These experiments provide a broader basis for the notion that those markers are expressed during blastogenesis of normal lymphocytes which are generally regarded as indicative of early lymphatic differentiation and of the stage of developmental arrest of acute lymphatic leukemias.
AU  - Jäger, G.
AU  - Lau, B.
AU  - Dörmér, P.G.
C1  - 33060
C2  - 38594
SP  - 421-423
TI  - Induction of cALL antigen and terminal deoxynucleotidyltransferase in normal peripheral lymphocyte during PHA stimulation.
JO  - Leuk. Res.
VL  - 6
IS  - 3
PY  - 1982
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Utilizing a technique of quantitative 14C-autoradiography, relative rates of cell production were determined in the various morphological cell compartments of erythro- and granulo-cytopoiesis in human myeloid leukemias. AML, chronic phase of CML as well as blastic crisis of CML were studied. From the ratios of relative cell production rates in the individual compartments of the white and red cell lineages and by comparison of the two lineages, implications concerning a reduction or increase of cell production are derived. A deficit of erythroblast production increasing with progression towards the more mature stages was attributed to ineffective erythropoiesis. The loss of erythroblasts in the proliferative pool ranged from 45% in CML to 79% in AML. The ratios of granulocytic precursor production in the various CML compartments (chronic phase) were normal. In AML and blastic crisis of CML, on the other hand, an excess of blast cell production was observed. In view of the complete analysis of all proliferative cells in these bone marrows, it appears that there is a capacity of blast cells to expand in number by self-amplification. This self-amplification is not necessarily restricted to one morphological cell type. It takes place among myeloblasts, but promyelocytes may also exhibit this 'leukemic' type of cell growth. The data further suggest that the stem cell influx into the red and presumably also granulocyte series is roughly normal in AML and blastic crisis of CML, whereas it is increased in CML.
AU  - Dörmér, P.G.
AU  - Lau, B.
AU  - Wilmanns, W.
C1  - 41495
C2  - 38832
SP  - 231-237
TI  - Kinetics of bone marrow cell production in human acute and chronic myeloid leukemias.
JO  - Leuk. Res.
VL  - 4
IS  - 21
PY  - 1980
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - cALL positive blast cells from peripheral blood of four children as well as cells from the Reh line were cultivated in DC in order to promote cell differentiation. DC were implanted into the peritoneal cavity of pre-irradiated CBA mice. At different intervals during the culture period changes in the membrane marker profile were determined by direct immunofluorescence after labeling the cells with AcALLG, ATCG and polyvalent AIg. In addition, the ability of cells to form rosettes with SRBC, AET-treated sheep erythrocytes and mouse red blood cells was tested. In the course of the culture the majority of cALL positive cells from three patients (T.H., V.M., I.G.) simultaneously developed a positive reaction with polyvalent AIg. Furthermore, a remarkable portion of cells in V.M. turned out to become positive with only AIg. Comparable results together with an increasing percentage of M-RFC were obtained in the fourth patient, C.M., using AIg(Fab)2. Besides this development, quite a few cells expressing the T-cell antigen occurred in the latter two patients. In the case of the Reh line, the cells developed T-cell antigen, and in one of two experiments they further acquired an E-receptor. Conversely, in the second experiment a receptor for mouse red blood cells was detected. Our data suggest that malignant cells carrying the cALLA are representative of an early developmental stage of lymphatic ontogeny.
AU  - Lau, B.
AU  - Jäger, G.
AU  - Thiel, E.V.
AU  - Pachmann, K.
AU  - Rodt, H.V.
AU  - Huhn, D.
AU  - Thierfelder, S.S.
AU  - Dörmér, P.G.
C1  - 41245
C2  - 38151
SP  - 561-569
TI  - Phenotypic changes in acute lymphoblastic leukemia cells of the common type in diffusion chambers.
JO  - Leuk. Res.
VL  - 4
IS  - 6
PY  - 1980
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - An immunohistochemical technique using the unlabeled antibody enzyme method was applied to tissue sections for identification of cells according to their surface antigens. The method and its diagnostic possibilities were demonstrated on four types of malignant lymphomas. Follicular centroblastic-centrocytic lymphomas contain T-cell regions distinctly separated from the follicular areas containing B-lymphocytes staining for one immunoglobulin class only. Lymphoplasmacytoid lymphomas have a small number of T-lymphocytes distributed between tumour cells as single cells or as small clusters. Whereas the majority of tumour cells showed ringlike labeling with anti-immunoglobulin, a small number of cells revealed diffuse cytoplasmic Ig-staining. Two cases with tumorous infiltrations of non-lymphatic tissues could be ascribed to ALL because they contained tumour cells stained with AcALLG. In one of them perivascular tumour cells positive with both AcALLG and anti-IgM were classified as pre-B cells.
AU  - Hoffmann-Fezer, G.
AU  - Thierfelder, S.S.
AU  - Pielsticker, K.*
AU  - Rodt, H.V.
C1  - 41826
C2  - 35749
SP  - 297-304
TI  - Immunohistochemical demonstration of cell surface antigens on tissue sections of lymphomas.
JO  - Leuk. Res.
VL  - 3
IS  - 5
PY  - 1979
SN  - 0145-2126
ER  - 

TY  - JOUR
AB  - Cell-kinetic investigations were carried out in a 15-year-old girl, initially presenting bicytopenia and changing gradually to cALL. At three instances during this transitional stage of the disease, the proliferation kinetics were studied in the cALL blast cell population as well as in erythroblasts and myelocytes. The percentage of blasts in the bone-marrow was 39, 42 and 70%, respectively. The DNA synthesis time in individual cells was measured by using the technique of quantitative 14C-autoradiography. Parallel with the increase in the number of blast cells a shortening of their time of DNA synthesis from 28.9 to 21.6 h was observed. Concomitantly with this development the kinetic parameters of erythroblasts and myelocytes normalized from initially extended values, and the anemia improved. A mutual inhibition between normal and malignant cell growth in bone marrow at the onset of overt leukemia is discussed as a possible interpretation of the course of the disease in this case.
AU  - Lau, B.
AU  - Dörmér, P.G.
AU  - Haas, R.J.*
AU  - Janka, G.E.*
C1  - 41837
C2  - 38446
SP  - 241-245
TI  - Proliferative activity of bone marrow cells in acute lymphocytic leukemia: Variation of cell kinetics with clinical manifestation.
JO  - Leuk. Res.
VL  - 2
IS  - 3
PY  - 1978
SN  - 0145-2126
ER  -