TY  - JOUR
AU  - Tom, R.Z.
AU  - Gao, Y.
AU  - Schriever, S.C.
AU  - Lutter, D.
AU  - Yi, C.-X.
AU  - Tschöp, M.H.
AU  - Hofmann, S.M.
C1  - 52445
C2  - 43979
CY  - Philadelphia
SP  - 702-702
TI  - Role of neuronal fractalkine in reducing diet-induced hypothalamic inflammation.
JO  - Med. Sci. Sports Exerc.
VL  - 49
IS  - 5
PB  - Lippincott Williams & Wilkins
PY  - 2017
SN  - 0025-7990
ER  - 

TY  - JOUR
AB  - PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia, which involves aberrant serotonin (5-hydroxytryptamine [5-HT]) and Akt signaling. As protective effects of chronic aerobic training (AT) have been demonstrated in the context of lung injury, this study investigated whether AT attenuates bleomycin-induced lung fibrosis partly via a reduction of 5-HT and AKT signaling. METHODS: Seventy-two C57BL/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi), and Fibrosis + Exercise (Fi + Ex) groups. Bleomycin (1.5 UI·kg) was administered on day 1 and treadmill AT began on day 15 and continued for 60 min·d, 5 d·wk for 4 wk. We evaluated total and differential cell counts in bronchoalveolar lavage (BAL), interleukin (IL)-1β, IL-6, CXCL1/KC, IL-10, tumor necrosis factor α, and transforming growth factor β levels in BAL, collagen content in lung parenchyma, 5-HT levels in BAL fluid and in serum, the expression of 5-HT2B receptor, and Akt phosphorylation in lung tissue. RESULTS: AT reduced bleomycin-increased number of total cells (P < 0.001), neutrophils (P < 0.01), macrophages (P < 0.01), and lymphocytes (P < 0.05) in BAL. It also reduced the levels of IL-1β (P < 0.01), IL-6 (P < 0.05), CXCL1/KC (P < 0.001), tumor necrosis factor α (P < 0.001), and transforming growth factor β (P < 0.001). It increased expression of ant-inflammatory cytokine IL-10 (P < 0.001). It reduced bleomycin-increased 5-HT levels in BAL (P < 0.001) and in serum (P < 0.05). Reductions in collagen fiber deposition (P < 0.01), 5-HT2B receptor expression (P < 0.01), and Akt phosphorylation in lung tissue were observed. CONCLUSIONS: AT accelerates the resolution of lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis partly via attenuation of 5-HT/Akt signaling.  
AU  - Pereira, P.R.*
AU  - Oliveira-Junior, M.C.*
AU  - MacKenzie, B.*
AU  - Chiovatto, J.E.D.*
AU  - Matos, Y.*
AU  - Greiffo, F.R.*
AU  - Rigonato-Oliveira, N.C.*
AU  - Brugemman, T.R.*
AU  - Delle, H.*
AU  - Idzko, M.*
AU  - Albertini, R.*
AU  - Ligeiro Oliveira, A.P.*
AU  - Damaceno-Rodrigues, N.R.*
AU  - Caldini, E.G.*
AU  - Fernandez, I.E.
AU  - Castro-Faria-Neto, H.C.*
AU  - Dolhnikoff, M.*
AU  - Eickelberg, O.
AU  - Vieira, R.P.*
C1  - 50418
C2  - 42203
SP  - 1276-1284
TI  - Exercise reduces lung fibrosis involving serotonin/akt signaling.
JO  - Med. Sci. Sports Exerc.
VL  - 48
IS  - 7
PY  - 2016
SN  - 0025-7990
ER  - 

TY  - JOUR
AB  - AUTENRIETH, C., A. SCHNEIDER, A. DORING, C. MEISINGER. C. HERDER, W. KOENIG, G. HUBER, and B. THORAND. Association between Different Domains of Physical Activity and Markers of Inflammation. Med. Sci. Sports Exerc., Vol. 41, No. 9. pp. 1706-1713, 2009. Purpose: Physical activity has recently been established as a potential modifier of the inflammatory process, suggesting that it mitigates inflammation and consequently reduces the incidence of several chronic diseases such as cardiovascular events. Methods: This study examined the association between different domains of self-reported physical activity (work, transportation, household, and leisure time) and three inflammatory markers (fibrinogen, C-reactive protein (CRP), and interleukin 6 (IL-6)). Study subjects included 796 men and women aged 35-74 yr with complete data for the main study variables who participated in the 1989/1990 MONItoring trends and determinants in CArdiovascular disease (MONICA) Augsburg Survey. Data were collected using the MONICA Optional Study on Physical Activity (MOSPA) questionnaire, and activity levels were classified into low, moderate, and vigorous physical activities. Results: Fibrinogen showed an inverse relationship with higher levels of work (P-trend = 0.038), transportation (P-trend = 0.025), leisure time (P-trend = 0.013), and summary physical activity (P-trend < 0.001). This relationship was still observed after adjusting for age and sex and further correction for body mass index, waist-to-hip ratio, smoking status, hypertension, diabetes, total-to-HDL cholesterol ratio, education, and self-reported limited physical activity due to health problems. IL-6 showed significant results for transportation (P-trend = 0.031), leisure time (P-trend = 0.016), and summary physical activity (P-trend < 0-000! whereas CRP was inversely related with the summary activity (P-trend = 0.003) in the fully adjusted model. No statistically significant inverse association between household physical activity and any of the investigated markers was found. We observed interactions between summary physical activity and smoking (fibrinogen: P = 0.003) as well as ex-smoking (CRP: P < 0.001; IL-6: P = 0.049). Conclusion: These data indicate that beyond leisure time, work and transportation physical activity may reduce inflammation.
AU  - Autenrieth, C.
AU  - Schneider, A.E.
AU  - Döring, A.
AU  - Meisinger, C.
AU  - Herder, C.*
AU  - Koenig, W.*
AU  - Huber, G.*
AU  - Thorand, B.
C1  - 1595
C2  - 26882
CY  - PHILADELPHIA
SP  - 1706-1713
TI  - Association between different domains of physical activity and markers of inflammation.
JO  - Med. Sci. Sports Exerc.
VL  - 41
IS  - 9
PB  - Lippincott Williams & Wilkins
PY  - 2009
SN  - 0025-7990
ER  - 

TY  - JOUR
AU  - Schneider, M.*
AU  - Bernasch, D.*
AU  - Weymann, J.*
AU  - Holle, R.
AU  - Bärtsch, P.*
C1  - 22289
C2  - 21086
SP  - 1886-1891
TI  - Acute mountain sickness : Influence of susceptibility, preexposure and ascent rate.
JO  - Med. Sci. Sports Exerc.
VL  - 34
PY  - 2002
SN  - 0025-7990
ER  -