TY  - JOUR
AU  - Seiringer, P.
AU  - Lauffer, F.
AU  - Pilz, A.C.
AU  - Boehmer, D.*
AU  - Biedermann, T.*
AU  - Eyerich, K.
C1  - 60034
C2  - 49819
CY  - Tradgardsgatan 14, Uppsala, Se-753 09, Sweden
TI  - Tofacitinib in hypertrophic lichen planus.
JO  - Acta Derm.-Venereol.
VL  - 100
IS  - 14
PB  - Acta Dermato-venereologica
PY  - 2020
SN  - 0001-5555
ER  - 

TY  - JOUR
AU  - Niculescu, L.*
AU  - Wagner, M.
AU  - Westphal, D.S.
AU  - Fischer, M.*
AU  - Mihatsch, W.*
AU  - Prothmann, A.*
AU  - Ruzicka, T.*
AU  - Wollenberg, A.*
AU  - Wolff, H.*
AU  - Schmidt, H.*
AU  - Giehl, K.A.*
C1  - 55078
C2  - 46027
CY  - Tradgardsgatan 14, Uppsala, Se-753 09, Sweden
SP  - 111-112
TI  - A case of ankyloblepharon- ectodermal defects-cleft lip/palate-syndrome with choanal atresia and skin erosions: Phenotypic variability of TP63-related disorders.
JO  - Acta Derm.-Venereol.
VL  - 99
IS  - 1
PB  - Acta Dermato-venereologica
PY  - 2019
SN  - 0001-5555
ER  - 

TY  - JOUR
AU  - Zink, A.*
AU  - Hänsel, I.*
AU  - Rotter, M.
AU  - Spinner, C.D.*
AU  - Böhner, A.*
AU  - Biedermann, T.*
C1  - 50744
C2  - 42664
CY  - Uppsala
SP  - 393-394
TI  - Impact of gliding on the prevalence of keratinocyte carcinoma and its precursors: A cross-sectional study among male pilots in Bavaria.
JO  - Acta Derm.-Venereol.
VL  - 97
IS  - 3
PB  - Acta Dermato-venereologica
PY  - 2017
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Punctate palmoplantar keratoderma (PPKP1; Buschke-Fischer-Brauer) is a rare autosomal dominant inherited skin disease characterized by multiple hyperkeratotic papules involving the palms and soles. Mutations have been found at 2 loci, on chromosomes 15q22-15q24 and 8q24.13-8q24.21. We recently identified mutations in 3 families, in the AAGAB gene on 15q, which encodes the alpha- and gamma-adaptin-binding protein p34. The current study examined 14 additional families, comprising a total of 26 affected individuals and identified 8 novel mutations in 9 families. In one family a mutation representing a known SNP that was present only in the affected individuals was found, and in 4 other families, previously reported mutations were found (1, 2). These results confirm the role of AAGAB in PPKP1. Our findings suggest that there is no correlation with age, but with mechanical factors. No additional obvious genotype phenotype correlation was observed, even when comparing different types of mutations. Rather, identical genotypes presented a very broad interfamilial and intrafamilial variability of phenotypes.
AU  - Giehl, K.A.*
AU  - Herzinger, T.*
AU  - Wolff, H.*
AU  - Sárdy, M.*
AU  - von Braunmuehl, T.*
AU  - Dekeule-Neer, V.*
AU  - Sznajer, Y.*
AU  - Tennstedt, D.*
AU  - Boes, P.*
AU  - Rapprich, S.*
AU  - Wagner, N.*
AU  - Betz, R.C.*
AU  - Braun-Falco, M.*
AU  - Strom, T.M.
AU  - Ruzicka, T.*
AU  - Eckstein, G.N.
C1  - 48712
C2  - 41303
CY  - Uppsala
SP  - 468-472
TI  - Eight novel mutations confirm the role of AAGAB in punctate palmoplantar keratoderma type 1 (Buschke-Fischer-Brauer) and show broad phenotypic variability.
JO  - Acta Derm.-Venereol.
VL  - 96
IS  - 4
PB  - Acta Dermato-venereologica
PY  - 2016
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE levels decreased after immunoadsorption and decreased continuously in all patients during anti-IgE therapy. The reverse trend was observed during 6 months follow-up without treatment. In parallel with these observations, an improvement in AD was observed during the treatment period, with aggravation during follow-up. Further research is needed, based on the principle of reducing IgE levels in order to improve clinical symptoms, using a combination anti-IgE treatment approach, adjusted according to IgE levels.
AU  - Zink, A.*
AU  - Gensbaur, A.*
AU  - Zirbs, M.*
AU  - Seifert, F.*
AU  - León Suárez, I.*
AU  - Mourantcha-Nian, V.*
AU  - Weidinger, S.*
AU  - Mempel, M.
AU  - Ring, J.
AU  - Ollert, M.
C1  - 47904
C2  - 39758
CY  - Uppsala
SP  - 72-76
TI  - Targeting IgE in severe atopic dermatitis with a combination of immunoadsorption and omalizumab.
JO  - Acta Derm.-Venereol.
VL  - 96
IS  - 1
PB  - Acta Dermato-venereologica
PY  - 2016
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/ capacitance), pH and clinical scoring of eczema (SCO-RAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation.
AU  - Jaeger, T.
AU  - Rothmaier, M.*
AU  - Zander, H.*
AU  - Ring, J.*
AU  - Gutermuth, J.
AU  - Anliker, M.D.*
C1  - 46640
C2  - 37655
CY  - Uppsala
SP  - 659-663
TI  - Acid-coated textiles (pH 5.5-6.5) - a new therapeutic strategy for atopic eczema?
JO  - Acta Derm.-Venereol.
VL  - 95
IS  - 6
PB  - Acta Dermato-venereologica
PY  - 2015
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - In approximately 20% of patients with suspected allergies, no organic symptom explanation can be found. Limited knowledge about patients with "medically unexplained symptoms (MUS)" contributes to them being perceived as "difficult" and being treated inadequately. This study examined the psychobehavioural characteristics of patients presenting for a diagnostic allergy work-up. Patients were interviewed and completed various self-rating questionnaires. Patient-Doctor interaction was evaluated, and the organic explicability of the patients' symptoms was rated by allergists. Patients with vs. those without MUS differed in several respects. Mental comorbidity, female sex, dissatisfaction with care, and a problematic countertransference (the interviewer's feelings towards the patient) independently predicted MUS. Patients whose symptoms could be explained organically reported more psychobeha-vioural problems than a control group of immuno-therapy patients. There were no differences in patient-doctor interaction. In patients with suspected allergies, recognition of psychological burden and concurrent mental disorders is important. Mental comorbidity and a difficult patient-doctor interaction may predict MUS.
AU  - Hausteiner-Wiehle, C.*
AU  - Grosber, M.*
AU  - Bubel, E.*
AU  - Groben, S.*
AU  - Bornschein, S.*
AU  - Lahmann, C.*
AU  - Eyer, F.*
AU  - Eberlein, B.
AU  - Behrendt, H.*
AU  - Löwe, B.*
AU  - Henningsen, P.*
AU  - Huber, D.*
AU  - Ring, J.
AU  - Darsow, U.
C1  - 6598
C2  - 28959
SP  - 666-673
TI  - Patient-doctor interaction, psychobehavioural characteristics and mental disorders in patients with suspected allergies: Do they predict 'medically unexplained symptoms'?
JO  - Acta Derm.-Venereol.
VL  - 91
IS  - 6
PB  - Soc. for. Publication of Acta Dermato-Venereologica
PY  - 2011
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found between eczema and the seven single nucleotide polymorphisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
AU  - Ekelund, E.*
AU  - Bradley, M.*
AU  - Weidinger, S.
AU  - Jovanovic, D.L.*
AU  - Johansson, C.*
AU  - Lindgren, C.M.*
AU  - Todorova, A.
AU  - Jakob, T.
AU  - Illig, T.
AU  - von Mutius, E.*
AU  - Braun-Fahrländer, C.*
AU  - Doekes, G.*
AU  - Riedler, J.*
AU  - Schehynius, A.*
AU  - Pershagen, G.*
AU  - Kockum, I.*
AU  - Kere, J.*
C1  - 554
C2  - 26475
SP  - 115-121
TI  - Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.
JO  - Acta Derm.-Venereol.
VL  - 89
IS  - 2
PB  - Acta Dermato-Venereologica
PY  - 2009
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Chronic itch is a common and distressing symptom that arises from a variety of skin conditions and systemic diseases. Despite this, there is no clinically based classification of pruritic diseases to assist in the diagnosis and cost-effective medical care of patients with pruritus. The proposed classification focuses on clinical signs and distinguishes between diseases with and without primary or secondary skin lesions. Three groups of conditions are proposed: pruritus on diseased (inflamed) skin (group I), pruritus on non-diseased (non-inflamed) skin (group II), and pruritus presenting with severe chronic secondary scratch lesions, such as prurigo nodularis (group III). The next part classifies the underlying diseases according to different categories: dermatological diseases, systemic diseases including diseases of pregnancy and drug-induced pruritus, neurological and psychiatric diseases. In some patients more than one cause may account for pruritus (category "mixed") while in others no underlying disease can be identified (category "others"). This is the first version of a clinical classification worked out by the members of the International Forum for the Study of Itch. It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care.
AU  - Ständer, S.*
AU  - Weisshaar, E.*
AU  - Mettang, T.*
AU  - Szepietowski, J.C.*
AU  - Carstens, E.*
AU  - Ikoma, A.*
AU  - Bergasa, N.V.*
AU  - Gieler, U.*
AU  - Misery, L.*
AU  - Wallengren, J.*
AU  - Darsow, U.
AU  - Streit, M.*
AU  - Metze, D.*
AU  - Luger, T.A.*
AU  - Greaves, M.W.*
AU  - Schmelz, M.*
AU  - Yosipovitch, G.*
AU  - Bernhard, J.D.*
C1  - 4164
C2  - 24736
SP  - 291-294
TI  - Clinical classification of itch: A position paper of the International Forum for the Study of Itch.
JO  - Acta Derm.-Venereol.
VL  - 87
IS  - 4
PB  - Forum for Nordic Dermato-Venereology
PY  - 2007
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - We evaluated the reproducibility of atopy patch test reactions and the quality and quantity of itch in 16 patients with atopic eczema and a history of a positive atopy patch test reaction, comparing three different application sites. The allergen was re-applied simultaneously on both forearms and the back. Intensity and quality of pruritus were evaluated using a visual analogue scale and the Eppendorf itch questionnaire, respectively. The atopy patch test reaction was highly reproducible, occurring in 15/16 (94%) patients. Pruritus was reported by 14/16 (88%) patients. There was no significant difference in either the intensity or quality of itch between the two forearms and the back (p>0.05). The mean peak visual analogue scale itch score was comparable across all three test sites (range 28.3-31.9). Regarding quantification of test reactions, a positive reaction was more frequent on the back (94% versus 69% on the arms) and the peak atopy patch test score was higher on the back compared with the arms (right forearm, p=0.0018 and left forearm, p=0.0683). Allergens should preferably be applied on the back for the atopy patch test. However, the atopy patch test can induce atopic itch irrespective of the application site.
AU  - Weissenbacher, S.
AU  - Bacon, T.*
AU  - Targett, D.*
AU  - Behrendt, H.
AU  - Ring, J.*
AU  - Darsow, U.
C1  - 2276
C2  - 23235
SP  - 147-151
TI  - Atopy patch test - reproducibility and elicitation of itch in different application sites.
JO  - Acta Derm.-Venereol.
VL  - 85
PY  - 2005
SN  - 0001-5555
ER  - 

TY  - JOUR
AB  - Oranges are suspected of inducing adverse skin reactions in patients with atopic eczema. We studied 21 adult patients with atopic eczema and a history of adverse reactions to oranges and 10 patients without. A dietary history, skin tests, serum IgE and oral provocation tests with oranges were obtained. Severity of eczema was monitored by SCORAD, and serum tryptase, eosinophil cationic protein and urinary methylhistamine were measured. No allergic reactions were found to orange in skin prick or patch tests. However, 23 patients (74%) had specific serum IgE to orange. Oral provocation testing resulted in pruritic eczematous or maculopapular skin lesions predominantly at the predilection sites in 16 patients (52%). The SCORAD increased significantly in patients positive to the oral provocation test (p <0.05). Specific IgE to orange did not correlate with the clinical outcome of the oral provocation test. No significant changes were found in serum mast cell tryptase, eosinophil cationic protein or in urinary methylhistamine excretion. The negative results in the skin tests and a lack of correlation between specific IgE and oral provocation tests indicate that non-IgE-mediated mechanisms are involved in cutaneous adverse reactions to oranges in patients with atopic eczema.
AU  - Brockow, K.
AU  - Hautmann, Ch.*
AU  - Fötisch, K.*
AU  - Rakoski, J.
AU  - Borelli, S.*
AU  - Vieths, S.*
AU  - Ring, J.
C1  - 10398
C2  - 21749
SP  - 44-48
TI  - Orange-induced skin lesions in patients with atopic eczema : Evidence for a Non-IgE-mediated mechanisms.
JO  - Acta Derm.-Venereol.
VL  - 83
IS  - 1
PY  - 2003
SN  - 0001-5555
ER  -