TY  - JOUR
AB  - OBJECTIVE: Low levels of social connectivity are related to the onset of type 2 diabetes mellitus (T2D), and this study investigates the role of body weight in this association. METHODS: In a sample of 9448 participants followed for a mean of 15.3 years (186,158.5 person-years) from the Monitoring of Trends and Determinants in Cardiovascular Disease Augsburg/Cooperative Health Research in the Region of Augsburg population-based cohort conducted in Germany, we investigated the association of social connectivity, measured by the Social Network Index, and body mass index (BMI) with the risk of clinically validated T2D incidence using stratified Cox proportional hazards regression models adjusted for sociodemographic, life-style, cardiometabolic, and psychosocial risk factors. RESULTS: During a mean follow-up of 14.1 years (186,158.5 person-years), 975 (10.3%) participants developed T2D. Participants with low social connectivity developed T2D at a higher rate than socially connected participants (10.0 versus 8.0 cases/10,000 person-years); however, BMI played a significant role in the association of social connectivity with T2D ( p < .001). In comparison to their socially connected counterparts, low social connectivity was associated with a higher rate of T2D incidence in normal-weight (6.0 versus 2.0 cases/10,000 person-years), but not overweight (13.0 versus 13.0 cases/10,000 person-years) or obese participants (32.0 versus 30.0 cases/10,000 person-years). Correspondingly, Cox regression analysis showed that 5-unit increments in BMI increased the risk of T2D in socially connected participants (hazard ratio = 3.03, 95% confidence interval = 2.48-3.79, p < .001) at a substantially higher rate than in low socially connected participants (hazard ratio = 1.77, 95% confidence interval = 1.45-2.16, p < .001). CONCLUSION: The detrimental link between low social connectivity and increased risk of T2D is substantially stronger in participants with a lower BMI.
AU  - Atasoy, S.*
AU  - Johar, H.
AU  - Kruse, J.*
AU  - Lukaschek, K.*
AU  - Peters, A.
AU  - Ladwig, K.H.*
C1  - 66727
C2  - 53246
SP  - 1050-1055
TI  - The association of social connectivity and body weight with the onset of type 2 diabetes: Findings from the population-based prospective MONICA/KORA cohort.
JO  - Psychosom. Med.
VL  - 84
IS  - 9
PY  - 2022
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Fangauf, S.V.*
AU  - Albus, C.*
AU  - Beutel M.*
AU  - Deter, H.C.*
AU  - Ladwig, K.-H.
AU  - Michal, M.*
AU  - Ronel, J.*
AU  - Soellner, W.*
AU  - Weber, C.S.*
AU  - de Zwaan, M.*
AU  - Herrmann-Lingen, C.*
C1  - 56189
C2  - 46877
CY  - Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
SP  - A28-A28
TI  - HSCRP is associated with impaired physical but not mental health-related quality of life in depressed patients with cad-results of the spirr-cad trial.
JO  - Psychosom. Med.
VL  - 81
IS  - 4
PB  - Lippincott Williams & Wilkins
PY  - 2019
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - Objective: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits. Methods: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkage disequilibrium score regression by combining summary statistics of previously conducted meta-analyses for depressive symptoms by CHARGE consortium (N = 51,258), T2D by DIAGRAM consortium (N = 34,840 patients and 114,981 controls), fasting glucose, fasting insulin, and homeostatic model assessment of β-cell function and insulin resistance by MAGIC consortium (N = 58,074). Finally, we investigated pleiotropic loci using a bivariate genome-wide association study approach with summary statistics from genome-wide association study meta-analyses and reported loci with genome-wide significant bivariate association p value (p < 5 10−8). Biological annotation and function of significant pleiotropic SNPs were assessed in several databases. Results: The SNP-based heritability ranged from 0.04 to 0.10 in each individual trait. In the linkage disequilibrium score regression analyses, depressive symptoms showed no significant genetic correlation with T2D or glycemic traits (p > 0.37). However, we identified pleiotropic genetic variations for depressive symptoms and T2D (in the IGF2BP2, CDKAL1, CDKN2B-AS, and PLEKHA1 genes), and fasting glucose (in the MADD, CDKN2B-AS, PEX16, and MTNR1B genes). Conclusions: We found no significant overall genetic correlations between depressive symptoms, T2D, or glycemic traits suggesting major differences in underlying biology of these traits. However, several potential pleiotropic loci were identified between depressive symptoms, T2D, and fasting glucose, suggesting that previously established phenotypic associations may be partly explained by genetic variation in these specific loci.
AU  - Haljas, K.*
AU  - Amare, A.T.*
AU  - Alizadeh, B.Z.*
AU  - Hsu, Y.H.*
AU  - Mosley, T.*
AU  - Newman, A.*
AU  - Murabito, J.*
AU  - Tiemeier, H.*
AU  - Tanaka, T.*
AU  - van Duijn, C.M.*
AU  - Ding, J.*
AU  - Llewellyn, D.J.*
AU  - Bennett, D.A.*
AU  - Terracciano, A.*
AU  - Launer, L.*
AU  - Ladwig, K.-H.
AU  - Cornelis, M.C.*
AU  - Teumer, A.*
AU  - Grabe, H.J.*
AU  - Kardia, S.L.R.*
AU  - Ware, E.B.*
AU  - Smith, J.A.*
AU  - Snieder, H.*
AU  - Eriksson, J.G.*
AU  - Groop, L.*
AU  - Räikkönen, K.*
AU  - Lahti, J.*
C1  - 52653
C2  - 44124
CY  - Po Box 211, 1000 Ae Amsterdam, Netherlands
SP  - 242-251
TI  - Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits.
JO  - Psychosom. Med.
VL  - 80
IS  - 3
PB  - Elsevier Science Bv
PY  - 2018
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Weber, C.S.*
AU  - Michal, M.*
AU  - Ronel, J.*
AU  - Ladwig, K.-H.
AU  - Herrmann-Lingen, C.*
AU  - Albus, C.*
AU  - Orth-Gomer, K.*
AU  - Rose, M.*
AU  - Deter, H.C.*
C1  - 51218
C2  - 42778
CY  - Philadelphia
SP  - A24-A25
TI  - Cortisol day profiles in patients with stable coronary heart disease and associations with anxiety - data from the spirr-cad trial.
JO  - Psychosom. Med.
VL  - 79
IS  - 4
PB  - Lippincott Williams & Wilkins
PY  - 2017
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - BACKGROUND: Depression predicts adverse prognosis in patients with coronary artery disease (CAD), but previous treatment trials yielded mixed results. We tested the hypothesis that stepwise psychotherapy improves depressive symptoms more than simple information. METHODS: In a multicenter trial, we randomized 570 CAD patients scoring higher than 7 on the Hospital Anxiety and Depression Scale-depression subscale to usual care plus either one information session (UC-IS) or stepwise psychotherapy (UC-PT). UC-PT patients received three individual psychotherapy sessions. Those still depressed were offered group psychotherapy (25 sessions). The primary outcome was changed in the Hospital Anxiety and Depression Scale-depression scores from baseline to 18 months. Preplanned subgroup analyses examined whether treatment responses differed by patients' sex and personality factors (Type D). RESULTS: The mean (standard deviation) depression scores declined from 10.4 (2.5) to 8.7 (4.1) at 18 months in UC-PT and from 10.4 (2.5) to 8.9 (3.9) in UC-IS (both p < .001). There was no significant group difference in change of depressive symptoms (group-by-time effect, p = .90). Preplanned subgroup analyses revealed no differences in treatment effects between men versus women (ptreatment-by-sex interaction = .799) but a significant treatment-by-Type D interaction on change in depressive symptoms (p = .026) with a trend for stronger improvement with UC-PT than UC-IS in Type D patients (n = 341, p = .057) and no such difference in improvement in patients without Type D (n = 227, p = .54). CONCLUSIONS: Stepwise psychotherapy failed to improve depressive symptoms in CAD patients more than UC-IS. The intervention might be beneficial for depressed CAD patients with Type D personality. However, this finding requires further study. TRIAL REGISTRATION: www.clinicaltrials.gov NCT00705965; www.isrctn.com ISRCTN76240576.
AU  - Herrmann-Lingen, C.*
AU  - Beutel, M.E.*
AU  - Bosbach, A.*
AU  - Deter, H.C.*
AU  - Fritzsche, K.*
AU  - Hellmich, M.*
AU  - Jordan, J.*
AU  - Jünger, J.*
AU  - Ladwig, K.-H.
AU  - Michal, M.*
AU  - Petrowski, K.*
AU  - Pieske, B.*
AU  - Ronel, J.*
AU  - Söllner, W.*
AU  - Stöhr, A.*
AU  - Weber, C.*
AU  - de Zwaan, M.*
AU  - Albus, C.*
C1  - 48614
C2  - 41223
CY  - Philadelphia
SP  - 704-715
TI  - A stepwise psychotherapy intervention for reducing risk in coronary artery disease: Results of an observer-blinded, multicenter, randomized trial in depressed patients with coronary artery disease.
JO  - Psychosom. Med.
VL  - 78
IS  - 6
PB  - Lippincott Williams & Wilkins
PY  - 2016
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Albus, C.*
AU  - Beutel, M.E.*
AU  - Deter, H.C.*
AU  - Fritzsche, K.*
AU  - Hellmich, M.*
AU  - Jordan, J.*
AU  - Jünger, J.*
AU  - Ladwig, K.-H.
AU  - Michal, M.*
AU  - Petrowski, K.*
AU  - Pieske, B.*
AU  - Ronel, J.*
AU  - Söllner, W.*
AU  - Stöhr, A*
AU  - Weber, C.S.*
AU  - Wiltink, J.*
AU  - de Zwaan, M.*
AU  - Herrmann-Lingen, C.*
AU  - SPIRR-CAD Study Group (*)
C1  - 31559
C2  - 34806
CY  - Philadelphia
SP  - A20
TI  - Rationale, design, and baseline data of the SPIRR-CAD trial.
JO  - Psychosom. Med.
VL  - 76
IS  - 3
PB  - Lippincott Williams & Wilkins
PY  - 2014
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Herrmann-Lingen, C.*
AU  - Beutel, M.E.*
AU  - Boese, A.*
AU  - Deter, H.C.*
AU  - Fritzsche, K.*
AU  - Hellmich, M.*
AU  - Jordan, J.*
AU  - Juenger, J.*
AU  - Ladwig, K.-H.
AU  - Michal, M.*
AU  - Petrowski, K.*
AU  - Pieske, B.*
AU  - Ronel, J.*
AU  - Soellner, W.*
AU  - Stöhr, A*
AU  - Weber, C.S.*
AU  - Wiltink, J.*
AU  - de Zwaan, M.*
AU  - Albus, C.*
AU  - SPIRR-CAD Study Group (*)
C1  - 31558
C2  - 34807
CY  - Philadelphia
SP  - A20
TI  - A stepwise psychotherapy intervention to reduce risk in coronary artery disease (SPIRR-CAD) first results of a large randomized multicenter trial.
JO  - Psychosom. Med.
VL  - 76
IS  - 3
PB  - Lippincott Williams & Wilkins
PY  - 2014
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To examine whether job strain is associated with an increased risk of subsequent Type 2 diabetes mellitus (T2DM) development in a population-based study of men and women. METHODS: Data were derived from the prospective MONICA/KORA Augsburg study. We investigated 5337 working participants aged 29 to 66 years without diabetes at one of the three baseline surveys. Job strain was measured by the Karasek job content questionnaire. High job strain was defined by the quadrant approach, where high job demands combined with low job control were classified as high job strain. Continuous job strain (quotient of job demands divided by job control) was additionally analyzed as sensitivity analysis. Hazard ratios (HRs) were estimated using multivariable Cox proportional hazards models with adjustment for age, sex, survey, socioeconomic and life-style variables, parental history of diabetes, and body mass index. RESULTS: During a median follow-up of 12.7 years, 291 incident cases of T2DM were observed. The participants with high job strain at baseline had a 45% higher fully adjusted risk to develop T2DM than did those with low job strain (HR = 1.45 [95% confidence interval = 1.00-2.10], p = .048). On the continuous scale, more severe job strain in the magnitude of 1 standard deviation corresponded to a 12% increased fully adjusted T2DM risk (HR = 1.12 [95% confidence interval = 1.00-1.25], p = .045). CONCLUSIONS: Men and women who experience high job strain are at higher risk for developing T2DM independently of traditional risk factors. Preventive strategies to combat the globally increasing T2DM epidemic should take into consideration the adverse effects of high strain in the work environment.
AU  - Huth, C.
AU  - Thorand, B.
AU  - Baumert, J.J.
AU  - Kruse, J.*
AU  - Emeny, R.T.
AU  - Schneider, A.E.
AU  - Meisinger, C.
AU  - Ladwig, K.-H.
C1  - 31884
C2  - 34843
CY  - Philadelphia
SP  - 562-568
TI  - Job strain as a risk factor for the onset of type 2 diabetes mellitus: Findings from the MONICA/KORA Augsburg cohort study.
JO  - Psychosom. Med.
VL  - 76
IS  - 7
PB  - Lippincott Williams & Wilkins
PY  - 2014
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - Background We examined the association between job strain and coronary heart disease (CHD) and investigated the role of markers of inflammation and endothelial dysfunction as possible mediators of job strain-associated CHD risk. Methods The sample (n = 1027) included employed participants (35-64 years old, 68% male) from the population-based MONICA/KORA (Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg) studies. At baseline Karasek's Job Strain Index was assessed during standardized personal interviews, and nine biological markers were measured (1984-1995). Participants were followed (average, 12 years) to assess incident events (sudden cardiac death or fatal and nonfatal myocardial infarction). In this case-cohort design, the final sample contained 114 cases and 913 noncases. Results Baseline distributions of cardiometabolic risk factors were significantly different between cases and noncases, with no detectable job strain-specific differences. However, cases with high job strain had higher monocyte chemoattractant protein-1, interleukin (IL)-8, and IL-18 compared with noncases with high job strain. High-sensitivity C-reactive protein, IL-6, and soluble intercellular adhesion molecule-1 were increased in cases versus noncases, regardless of work stress. Job strain was associated with incident coronary events in Cox proportional hazards models adjusted for age, sex, and survey (hazard ratio = 2.57, 95% confidence interval = 1.09-6.07) and after adjustment for CHD risk factors (2.35, 1.003-5.49). Adjustment for monocyte chemoattractant protein-1 or IL-8 increased this risk estimate by 14.5% or 9.4%, respectively, whereas adjustment for C-reactive protein and soluble intercellular adhesion molecule-1 led to decreased hazard ratios (-9.9% and -5.5%, respectively). Conclusions Job strain increased CHD risk in healthy workers; the associated inflammatory burden may contribute to stress-related coronary pathogenesis.
AU  - Emeny, R.T.
AU  - Zierer, A.*
AU  - Lacruz, M.E.
AU  - Baumert, J.J.
AU  - Herder, C.*
AU  - Gornitzka, G.*
AU  - Koenig, W.*
AU  - Thorand, B.
AU  - Ladwig, K.-H.
C1  - 24145
C2  - 31335
CY  - Philadelphia
SP  - 317-325
TI  - Job strain-associated inflammatory burden and long-term risk of coronary events: Findings from the MONICA/KORA Augsburg case-cohort study.
JO  - Psychosom. Med.
VL  - 75
IS  - 3
PB  - Lippincott Williams & Wilkins
PY  - 2013
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Ladwig, K.-H.
AU  - Huth, C.
AU  - Thorand, B.
AU  - Baumert, J.J.
AU  - Emeny, R.T.
AU  - Kruse, J.*
AU  - Meisinger, C.*
C1  - 30691
C2  - 33912
CY  - Philadelphia
SP  - A25
TI  - Job strain as a risk factor for the onset of type 2 diabetes: Results from the MONICA/KORA Augsburg cohort study.
JO  - Psychosom. Med.
VL  - 75
IS  - 3
PB  - Lippincott Williams & Wilkins
PY  - 2013
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To explore the prevalence of Type D personality-the combination of negative affectivity and social inhibition-in the general population and its relationship to other cardiovascular risk factors, including psychopathological symptoms. Type D personality has been identified as a prognostic risk factor for various cardiovascular disease conditions. METHODS: In a representative sample of 2698 individuals (aged 35-74 years), psychological, lifestyle, and somatic risk factors were investigated with laboratory testing, self-report measures, and a clinical interview. Type D was assessed with the German Type D Scale-14. RESULTS: The prevalence of Type D was 23.4% (95% confidence interval [CI], 21.2-25.6) in men and 26.9% (95% CI, 23.7-30.1) in women and, thus, in the range of classical risk factors (e.g., hypercholesterolemia). In age-adjusted analysis, Type D was associated with psychopathological symptoms, including depression and somatic symptom burden. With the exception of physical inactivity in both sexes, hypertension in women and hypercholesterolemia in men, Type D was not associated with classical cardiovascular risk factors. Multivariate analysis revealed depression, exhaustion, anxiety, and low self-rated health as associated with Type D in both sexes (odds ratios, 1.97-3.21 in men, 1.52-2.44 in women). CONCLUSIONS: A Type D personality disposition can be found in about a quarter of the general population, which is comparable to the prevalence of classical cardiovascular risk factors. In both sexes, an independent association to Type D appeared mainly in psychopathological symptoms. Type D constitutes a relevant and independent risk marker in the community and should receive attention in clinical practice.
AU  - Hausteiner, C.*
AU  - Klupsch, D.
AU  - Emeny, R.T.
AU  - Baumert, J.J.
AU  - Ladwig, K.-H.
C1  - 1045
C2  - 27315
SP  - 163-171
TI  - Clustering of negative affectivity and social inhibition in the community: Prevalence of type D personality as a cardiovascular risk marker.
JO  - Psychosom. Med.
VL  - 72
IS  - 2
PB  - Lippincott Williams & Wilkins
PY  - 2010
SN  - 0033-3174
ER  - 

TY  - JOUR
AB  - Objective: To examine sex-specific associations between living alone and incident Type 2 diabetes mellitus in a representative population sample in Germany. Methods: The study was based on 4424 men and 4380 women (aged 35-74 years) who participated in one of the three Monitoring trends and determinants on cardiovascular diseases Augsburg surveys between 1984 and 1995 and who were free of diabetes at baseline. Sex-specific hazard ratios (HRs) were estimated from Cox proportional hazard models. Results: A total of 402 cases of incident Type 2 diabetes among men and 271 among women were registered during the mean follow-up period of 10.9 years. Living alone was significantly associated with incident Type 2 diabetes in men but not in women. After adjustment for age, survey, parental history of diabetes, hypertension, dyslipidemia, smoking, physical activity, alcohol intake, and body mass index, the risk of developing diabetes for those who lived alone at baseline compared with those who did not live alone was 1.69 (95% confidence interval (CI), 1.19-2.37) in men and 0.85 (95% CI, 0.57-1.24) in women; the p value for the sex interaction was .006 in this model. Inclusion of education and depressed mood in the models in addition to other risk factors had no impact on the observed HRs in women and even increased the risk in men (women: HR, 0.83; 95% CI, 0.52-1.32; men: HR, 1.89; 95% CI, 1.33-2.70). Conclusions: Living alone is an independent predictor of Type 2 diabetes in men but not in women from the general population.
AU  - Meisinger, C.
AU  - Kandler, U.
AU  - Ladwig, K.-H.
C1  - 1644
C2  - 26957
CY  - Philadelphia
SP  - 784-788
TI  - Living alone is associated with an increased risk of type 2 diabetes mellitus in men but not women from the general population: The MONICA/KORA Augsburg cohort study.
JO  - Psychosom. Med.
VL  - 71
IS  - 7
PB  - Lippincott Williams & Wilkins
PY  - 2009
SN  - 0033-3174
ER  - 

TY  - JOUR
AU  - Baumert, J.J.
AU  - Schmitt, C.*
AU  - Ladwig, K.-H.
C1  - 5581
C2  - 23786
SP  - 591-597
TI  - Psychophysiologic and affective parameters associated with pain intensity of cardiac cardioverter defibrillator shock discharges.
JO  - Psychosom. Med.
VL  - 68
PY  - 2006
SN  - 0033-3174
ER  -