DeMeo, B.* et al. Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes. Science, DOI: 10.1126/science.adi8577:eadi8577 (2025)
Di Fraia, D.* et al. Altered translation elongation contributes to key hallmarks of aging in the killifish brain. Science 389:eadk3079 (2025)
Furtwangler, B.* et al. Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics. Science 390:eadr8785 (2025)
Götz, M. & Torres-Padilla, M.E. Stem cells as role models for reprogramming and repair. Science 388:eadp2959 (2025)
Loveland, J.L.* et al. A single gene orchestrates androgen variation underlying male mating morphs in ruffs. Science 387, 406-412 (2025)
Waltz, F.* et al. In-cell architecture of the mitochondrial respiratory chain. Science 387, 1296-1301 (2025)
Zhu, X.* et al. Measurements of molecular size and shape on a chip. Science 388:eadt5827 (2025)
Ham, H.* et al. Germline mutations in a G protein identify signaling cross-talk in T cells. Science 385:eadd8947 (2024)
Keipert, S.* et al. Two-stage evolution of mammalian adipose tissue thermogenesis. Science 384, 1111-1117 (2024)
Li, Y.* et al. The landscape of RNA-binding proteins in mammalian spermatogenesis. Science 386:eadj8172 (2024)
Müller-Durovic, B.* et al. A metabolic dependency of EBV can be targeted to hinder B cell transformation. Science 385:eadk4898 (2024)
Reddy, N.R.* et al. Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs. Science 386:eadl4793 (2024)
Zocher, S.* et al. Lifelong persistence of nuclear RNAs in the mouse brain. Science 384, 53-59 (2024)
Naraoka, H.* et al. Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu. Science 379:eabn9033 (2023)
Singh, P.* et al. Taurine deficiency as a driver of aging. Science 380:eabn9257 (2023)
Wheeler, M.A.* et al. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science 379, 1023-1030 (2023)
Zeichner, S.S.* et al. Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium. Science 382, 1411-1416 (2023)
Ziegler, K.A.* et al. Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science 381, 285-290 (2023)
Border, R.* et al. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science 378, 754-761 (2022)
O'Neill, A.C. et al. Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity. Science 376:eabf9088 (2022)
Reichart, D.* et al. Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science 377:eabo1984 (2022)
van den Hoek, H. et al. In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains. Science 377, 543-548 (2022)
Pietzner, M.* et al. Mapping the proteo-genomic convergence of human diseases. Science 374:eabj1541 (2021)
Tyser, R.C.V.* et al. Characterization of a common progenitor pool of the epicardium and myocardium. Science 371:eabb2986 (2021)
Kutschera, A.* et al. Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants. Science 364, 178-181 (2019)
Zeggini, E. ; Gloyn, A.L.* ; Barton, A.C.* & Wain, L.V.* Translational genomics and precision medicine: Moving from the lab to the clinic. Science 365, 1409-1413 (2019)
Conrad, M. Molecular underpinnings controlling ferroptotic cell death. Science 120, S7-S7 (2018)
Dawed, A.Y.* et al. GLP-1 receptor variants markedly differentiate glycaemic response to GLP-1 receptor agonists: A direct study. Science 123, 13-14 (2018)
International Wheat Genome Sequencing Consortium (Eversole, K.* ; Feuillet, C.* ; Keller, B.* ; Rogers, J.* ; Stein, N.* ; Appels, R.*) et al. Shifting the limits in wheat research and breeding using a fully annotated reference genome. Science 361:eaar7191 (2018)
Fedoseeva, M. et al. The alternative NF kappa B pathway regulates accumulation of tissue Tregs and protects from experimental autoimmune encephalomyelitis. Science 48, 53-53 (2018)
Frey, K.* ; Lauffer, F.* ; Garzorz-Stark, N.* ; Eyerich, S. & Eyerich, K.* Mapping of disease severity in patients with systemic sclerosis. Science 27, E23-E23 (2018)
Götz, M. Revising concepts about adult stem cells. Science 359, 639-640 (2018)
Griesmann, M. et al. Phylogenomics reveals multiple losses of nitrogen-fixing root nodule symbiosis. Science 361:eaat1743 (2018)
Hiller, J. et al. STAT1/STAT3 imbalance determines the clinical phenotype of chronic mucocutaneous candidiasis. Science 27, E49-E50 (2018)
Lauffer, F.* et al. IL-17C: Checkpoint in innate skin immunology. Science 27, E55-E55 (2018)
Plass, M.* et al. Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science 360:eaaq1723 (2018)
Ramirez-Gonzalez, R.H.* et al. The transcriptional landscape of polyploid wheat. Science 361 (2018)
Avni, R.* et al. Wild emmer genome architecture and diversity elucidate wheat evolution and domestication. Science 357, 93-97 (2017)
Dawidowski, M. et al. Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science 355, 1416-1420 (2017)
Jastroch, M. & Tschöp, M.H. METABOLISM. Fat controls U. Circulating uridine acts as a hunger signal. Science 355, 1124-1125 (2017)
Klaeger, S.* et al. The target landscape of clinical kinase drugs. Science 358:eaan4368 (2017)
Koch, B.P.* et al. Response to Comment on "Dissolved organic sulfur in the ocean: Biogeochemistry of a petagram inventory". Science 356:813 (2017)
Ksionzek, K.B.* et al. Dissolved organic sulfur in the ocean: Biogeochemistry of a petagram inventory. Science 354, 456-459 (2016)
Sahl, S.J.* et al. Comment on "Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics". Science 352:527 (2016)
Zanoni, P.* et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 351, 1166-1671 (2016)
Barbosa, J.S. et al. Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain. Science 348, 789-793 (2015)
Ohnmacht, C. et al. The microbiota regulates type 2 immunity through RORγt+ T cells. Science 349, 989-993 (2015)
International Wheat Genome Sequencing Consortium (Appels, R.* ; Mayer, K.F.X. ; Rogers, J.* ; Eversole, K.* ; Feuillet, C.* ; Stein, N.* ; Keller, B.*) et al. A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome. Science 345:1251788 (2014)
Choulet, F.* et al. Structural and functional partitioning of bread wheat chromosome 3B. Science 345:1249721 (2014)
Eversole, K.* ; Feuillet, C.* ; Mayer, K.F.X. & Rogers, J.* Slicing the wheat genome. Science 345, 285-287 (2014)
Lucifora, J. et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343, 1221-1228 (2014)
Marcussen, T.* et al. Ancient hybridizations among the ancestral genomes of bread wheat. Science 345:1250092 (2014)
Meckenstock, R.U. et al. Water droplets in oil are microhabitats for microbial life. Science 345, 673-676 (2014)
Pfeifer, M. et al. Genome interplay in the grain transcriptome of hexaploid bread wheat. Science 345:1250091 (2014)
Tedersoo, L.* et al. Global diversity and geography of soil fungi. Science 346:1256688 (2014)
Xia, Y. ; Lucifora, J. ; Reisinger, F. ; Heikenwälder, M. & Protzer, U. Response to comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA". Science 344:1237 (2014)
Buchholz, V.R.* et al. Disparate individual fates compose robust CD8+ T cell immunity. Science 340, 630-635 (2013)
Fenner, K.* ; Canonica, S.* ; Wackett, L.P.* & Elsner, M. Evaluating pesticide degradation in the environment: Blind spots and emerging opportunities. Science 341, 752-758 (2013)
Kruglov, A.A.* et al. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science 342, 1243-1246 (2013)
Mori, K.* et al. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science 339, 1335-1338 (2013)
Popova, O.P.* et al. Chelyabinsk airburst, damage assessment, meteorite recovery, and characterization. Science 342, 1069-1073 (2013)
Rietveld, C.A.* et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 340, 1467-1471 (2013)
Bonilla, W.V.* et al. The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 335, 984-989 (2012)
Jenniskens, P.* et al. Radar-enabled recovery of the Sutter's Mill meteorite, a carbonaceous chondrite regolith breccia. Science 338, 1583-1587 (2012)
Meyer, A.* et al. CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science 336, 1723-1725 (2012)
Saab, A.S.* et al. Bergmann glial AMPA receptors are required for fine motor coordination. Science 337, 749-753 (2012)
Mendiburo, M.J.* ; Padeken, J.* ; Fülöp, S. ; Schepers, A. & Heun, P.* Drosophila CENH3 is sufficient for centromere formation. Science 334, 686-690 (2011)
Refojo, D.* et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333, 1903-1907 (2011)
Sims, R.J.* et al. The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science 332, 99-103 (2011)
Schirawski, J.* et al. Pathogenicity determinants in smut fungi revealed by genome comparison. Science 330, 1546-1548 (2010)
Schofield, P.N.* et al. Research funding: Sustaining the data and bioresource commons. Science 330, 592-593 (2010)
Vegiopoulos, A.* et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010)
Blandin, S.A.* et al. Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Science 326, 147-150 (2009)
Rieger, M. ; Hoppe, P.S. ; Smejkal, B.M. ; Eitelhuber, A.C. & Schroeder, T. Hematopoietic cytokines can instruct lineage choice. Science 325, 217-218 (2009)
Worden, A.Z.* et al. Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas. Science 324, 268-272 (2009)
Rensing, S.A.* et al. The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants. Science 319, 64-69 (2008)
Chapman, R.D. et al. Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science 318, 1780-1782 (2007)
Cuomo, C.A.* et al. The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science 317, 1400-1402 (2007)
Egloff, S.* et al. Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression. Science 318, 1777-1779 (2007)
Herbert, A.* et al. Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity". Science 315, 187e (2007)
Herbert, A.* et al. A common genetic variant is associated with adult and childhood obesity. Science 312, 279-283 (2006)
Horn, M.* ; Frishman, D. ; Rattei, T. & Mewes, H.-W. Illuminating the evolutionary history of chlamydiae. Science 304, 728-730 (2004)
Hafezparast, M.* et al. Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport. Science 300, 808-812 (2003)
Gupta, S.S.* et al. Rapid Total Destruction of Chlorophenols by Activated Hydrogen Peroxide.  Science 296, 326-328 (2002)
Meisterernst, M. Mediator Meets Morpheus. Science 295, 984-985 (2002)
Sillaber, I.* et al. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 recepors. Science 296, 931-933 (2002)
Nadeau, J.H.* et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science 291, 1251-1255 (2001)
Hermeking, H. & Eick, D. Mediation of c-myc-induced apoptosis by p53. Science 265, 2091-2093 (1994)
Schallreuter, K.U.* et al. Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263, 1444-1446 (1994)