TY  - JOUR
AB  - The latent membrane protein 1 (LMP1) of Epstein-Barr virus is a viral oncogene with the potential to antagonize apoptosis and senescence as well as to promote cellular survival and proliferation. LMP1 acts like a constitutively active receptor recruiting signalling molecules typically employed by the cellular tumour necrosis factor-receptor (TNF-R) and Toll-like/interleukin-1-receptor (TIR) families. LMP1 activates the classical and alternative NF-jB pathways, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), the JAK/STAT and phosphatidylinositol 3-kinase (PI3K) pathways. In this article, interactions of LMP1 with host cell signal transduction pathways and their role in LMP1-induced cell transformation are reviewed.
AU  - Kieser, A.
C1  - 5675
C2  - 28275
CY  - Weinheim
SP  - 20-33
TI  - Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1).
JO  - Signal Transduct.
VL  - 7
IS  - 1
PB  - Wiley-VCH
PY  - 2007
SN  - 1615-4053
ER  - 

TY  - JOUR
AU  - Kieser, A.
C1  - 5676
C2  - 28276
SP  - 3-4
TI  - Signal transduction by viral factors: Critical interface between the virus and ist host cell with implications for the viral life cycle and disease development.
JO  - Signal Transduct.
VL  - 7
IS  - 1
PB  - Wiley-VCH
PY  - 2007
SN  - 1615-4053
ER  -