TY  - JOUR
AU  - Muri, J.*
AU  - Heer, S.*
AU  - Matsushita, M.*
AU  - Pohlmeier, L.*
AU  - Tortola, L.*
AU  - Fuhrer, T.*
AU  - Conrad, M.
AU  - Zamboni, N.*
AU  - Kisielow, J.*
AU  - Kopf, M.*
C1  - 54696
C2  - 45760
CY  - Farnsburgerstr 8, Ch-4132 Muttenz, Switzerland
SP  - 8S-8S
TI  - The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell but not B-cell metabolic reprogramming and proliferation.
JO  - Swiss Med. Wkly.
VL  - 148
PB  - E M H Swiss Medical Publishers Ltd
PY  - 2018
SN  - 0036-7672
ER  - 

TY  - JOUR
AB  - AIMS OF THE STUDY: Nonmelanoma skin cancer (NMSC) is the most common cancer in Switzerland and Europe. The main causative factor is exposure to ultraviolet radiation, which puts outdoor workers in general at a higher risk of developing NMSC than indoor workers. However, few studies have clinically examined the risk of developing NMSC to outdoor workers, especially mountain guides. We aimed to investigate the prevalence of NMSC and corresponding precancerous lesions, and the associated risk behaviour of mountain and ski guides in order to develop future prevention programmes.METHODS: We conducted a cross-sectional study including mountain and ski guides from southern Germany, who underwent a full-body skin check-up by a dermatologist. We assessed their NMSC awareness and risk behaviour using a paper-based questionnaire.RESULTS: Of the 62 state-certified mountain and ski guides (55 men, 7 women; mean age 52.9 ± 13.4 years) included in this study, 27 (43.5%) were diagnosed with NMSC or its premalignant stages. In addition, 59.7% of the participants expressed the opinion that their protection from ultraviolet radiation exposure needs to be improved; 83.6% requested further information on NMSC, and 48.5% had never undergone a skin check-up or consulted a dermatologist before.CONCLUSIONS: Mountain and ski guides are at a high risk for developing NMSC. Their unmet medical needs indicate an underestimation of NMSC prevalence, which is usually based on reports by insurance companies, and offer the chance for developing evidence-based awareness and prevention tools that can be promoted to individuals with other outdoor jobs.
AU  - Zink, A.*
AU  - Koch, E.*
AU  - Seifert, F.*
AU  - Rotter, M.
AU  - Spinner, C.D.*
AU  - Biedermann, T.*
C1  - 50794
C2  - 42637
CY  - Muttenz
TI  - Nonmelanoma skin cancer in mountain guides: High prevalence and lack of awareness warrant development of evidence-based prevention tools.
JO  - Swiss Med. Wkly.
VL  - 146
PB  - E M H Swiss Medical Publishers Ltd
PY  - 2016
SN  - 0036-7672
ER  - 

TY  - JOUR
AB  - In recent years, enormous progress has been made in identifying microRNAs (miRNAs) as important regulators of gene expression and their association with or control of various liver diseases such as fibrosis, hepatitis and hepatocellular carcinoma (HCC). Indeed, many genes encoding miRNAs as well as their targets have been described and their direct or indirect link to the respective liver diseases has been investigated in various experimental systems as well as in human tissue. Here we discuss current knowledge of miRNAs and their involvement in liver diseases, elaborating in particular on the contribution of miRNAs to hepatitis, fibrosis and HCC formation. We also debate possible prognostic, predictive and therapeutic values of respective miRNAs in liver diseases. The discovery of liver disease related miRNAs has constituted a major breakthrough in liver research and will most likely be of high relevance for future therapeutic strategies, especially when dealing with hepatitis, fibrosis and HCC.
AU  - Haybaeck, J.*
AU  - Zeller, N.*
AU  - Heikenwälder, M.
C1  - 6873
C2  - 29376
TI  - The parallel universe: MicroRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.
JO  - Swiss Med. Wkly.
VL  - 141
PB  - E M H Swiss Medical Publishers Ltd.
PY  - 2011
SN  - 0036-7672
ER  - 

TY  - JOUR
AB  - To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity. DESIGN: A total of 163 consecutive patients were enrolled for comprehensive cardiac rehabilitation (CCR) following a recent coronary event, to outpatient or inpatient CCR according to treatment preference because randomisation was accepted by only 4 patients. CCR was six hours per day for 4 weeks and consisted of exercise training, education, psychological support, and nutritional and occupational advice. Examinations were before, after and 12 months after CCR. Primary outcome measures were event-free survival with or without interventions, EFS-I or EFS, respectively, 12 months after rehabilitation. RESULTS: Main patient characteristics were distributed equally in the cohorts. Results were adjusted by logistic regression for age, BMI, LV-function, exercise capacity and physical activity before the event. Adjusted EFS, EFS-I , overall survival and other morbidity outcome measures did not differ significantly. During CCR, physical activity was higher in outpatients, but this difference was not maintained in the follow up. Average physical activity was increased 12 month after CR with no difference between groups. CONCLUSION: Although influenced by patient preference, participation in either inpatient or outpatient CCR led to comparable results in terms of all-cause or cardiac overall survival, event-free survival and other secondary outcome measures like cardiac morbidity, physical performance and increased physical activity.
AU  - Steinacker, J.M.*
AU  - Liu, Y.*
AU  - Muche, R.*
AU  - Koenig, W.*
AU  - Hahmann, H.*
AU  - Imhof, A.
AU  - Kropf, C.
AU  - Brandstetter, S.
AU  - Schweikert, B.*
AU  - Leidl, R.
AU  - Schiefer, D.H.*
C1  - 6429
C2  - 28668
TI  - Long term effects of comprehensive cardiac rehabilitation in an inpatient and outpatient setting.
JO  - Swiss Med. Wkly.
VL  - 141
IS  - JANUARY
PB  - EMH Swiss Medical Publishers Ltd.
PY  - 2011
SN  - 0036-7672
ER  - 

TY  - JOUR
AB  - Inflammatory responses in the liver--a central constituent of hepatic wound healing--can be self-limited or persistent depending on the aetiology, liver health state, concentration of toxins or pathogens, and the time frame of exposure to toxins or infection. In case the immune system eradicates a pathogen or in case toxin-exposure is transient, acute hepatitis resolves and the affected liver tissue regenerates ad integrum. However, in many cases liver damage remains chronic. Irrespective of the aetiology, chronic liver damage drives chronic hepatitis and hepatocyte death as well as compensatory proliferation, reflecting liver regeneration. Over time this potentially promotes further hepatic damage, fibrosis, cirrhosis and liver cancer. Here, we review the current knowledge on how chronic liver injury and inflammation is triggered and maintained, and how inflammation is linked to liver cancer. We also discuss the most frequently used animal models for damage or inflammation induced liver cancer and their suitability for conducting clinically relevant research.
AU  - Weber, A.*
AU  - Boege, Y.*
AU  - Reisinger, F.
AU  - Heikenwälder, M.
C1  - 6570
C2  - 28881
TI  - Chronic liver inflammation and hepatocellular carcinoma: Persistence matters.
JO  - Swiss Med. Wkly.
VL  - 141
PB  - EMH Swiss Medical Publishers Ltd.
PY  - 2011
SN  - 0036-7672
ER  - 

TY  - JOUR
AB  - Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the developed world and associated with a high individual and socioeconomic burden. Despite emerging preventive efforts and ongoing clinical trials, the frequency and mortality of COPD are expected to continue to rise over the next decades. COPD is defined as an irreversible expiratory airflow limitation, which is caused by various degrees of the following two main features: First, small airway disease (SAD), which includes airway inflammation and remodelling, and second, emphysema, which is characterised by airspace enlargement. The major risk factor for COPD is cigarette smoke exposure; however, the molecular mechanisms linking smoke to different COPD features on the cellular level remain elusive. The transforming growth factor (TGF)-β superfamily constitutes more than 40 members, which are essential during organ development, a process often recapitulated in chronic diseases. Emerging interest in the role of TGF-β in the pathogenesis of COPD has recently evolved, particularly since genetic studies have demonstrated an association of gene polymorphisms of the TGF-β superfamily with COPD. In addition, increased expression of TGF-β1 in COPD lungs and primary cells, such as epithelial cells, macrophages, or fibroblasts isolated from COPD specimens, was reported, suggesting an impact of TGF-β signalling on the development and progression of COPD. Thus, targeted interventions of TGF-β signalling may represent a suitable therapeutic option in COPD. In this review, we will summarise the current understanding of the impact of TGF-β in COPD pathogenesis. The review is separated into five chapters: 1) an introduction to COPD, 2) an introduction to TGF-β signalling, 3) a summary of TGF-β gene polymorphisms in COPD, 4) a summary of TGF-β signalling in small airway disease, and 5) a summary of TGF-β signalling in emphysema.
AU  - Königshoff, M.
AU  - Kneidinger, N.*
AU  - Eickelberg, O.
C1  - 250
C2  - 26735
SP  - 554-563
TI  - TGF-β signalling in COPD: Deciphering genetic and cellular susceptibilities for future therapeutic regimen.
JO  - Swiss Med. Wkly.
VL  - 139
IS  - 39-40
PB  - EMH Swiss Medical Publishers
PY  - 2009
SN  - 0036-7672
ER  -