TY - JOUR AB - Inbred strains are the raw material for the generation of Genetically Engineered Mice (GEM) that have become indispensable tools for cancer research, and for the identification of genes involved in human diseases. The "German Mouse Clinic" was designed to provide the scientific community with a systematic, standardized and comprehensive phenotyping of mouse models on various genetic backgrounds and generated by different methods (transgenic, knockouts, ENU mutagenesis screen and gene-trap approaches). The pathology screen within the German Mouse-Clinic was conceived to ensure a complete morphologic phenotype of mouse models, to support discovery of genes functions, and to understand how these genes influence the development of human diseases. The goal is to define disease entities that can be recognized by a pathologist and relate them to human disorders when possible. Knowing the inherent morphologic phenotype of the most frequent used mouse strains is of utmost importance for the correct interpretation of mouse models. The main challenges, which pathologist are confronted to validate mouse models for human diseases include (1) knowledge of mouse biology and of histological differences between mouse strains and humans, (2) the terminology that should be used for the classification of neoplastic lesions in GEM's, (3) to asses the usefulness of a particular GEM as model for a human disease. AU - Mossbrugger, I. AU - Hoelzlwimmer, G. AU - Calzada-Wack, J. AU - Quintanilla-Martinez, L. C1 - 3813 C2 - 25036 SP - 98-103 TI - Standardized morphological phenotyping of mouse models of human diseases within the German Mouse Clinic. JO - Verh. Dtsch. Ges. Pathol. VL - 91 PB - Urban & Fischer PY - 2007 SN - 0070-4113 ER - TY - JOUR AU - Herbst, H.* AU - Sauter, M.* AU - Boese, A.* AU - Galli, U.* AU - Best, B.* AU - Mayer, J.* AU - Kaevel, J.* AU - Kremmer, E. AU - Roemer, K.* AU - Müller-Lantzsch, N.* C1 - 21861 C2 - 20060 SP - 279-285 TI - Molekulare Pathogenese von Keimzelltumoren : Das transformierende Protein p 15cORF aus Endogenen Retroviren HERV-K bindet das PLZF-Protein. JO - Verh. Dtsch. Ges. Pathol. VL - 85 PY - 2001 SN - 0070-4113 ER - TY - JOUR AB - Newborn hMT-fos-LTR transgenic C3H mice and their non-transgenic siblings were infected with Akv, derived from the ecotropic provirus of the AKR mouse. Bone sarcomas in non-infected transgenics were observed in 20% (3/15) of females at 448 +/- 25 days and in 8% (1/12) of males at 523 days. Akv-infected transgenics developed bone tumors with higher frequency and at younger age: Females in 69% (20/28) at 268 +/- 122 days, males in 83% (24/29) at 279 +/- 109 days. In the majority of the bone tumors of Akv-infected transgenics (70% in females, 59% in males) cellular atypia was lacking and the histological pattern resembled human parosteal osteosarcoma. Only 50% (12/24) of bone tumors in Akv-infected transgenics revealed newly integrated virus sequences by Southern analysis. PCR analysis detected Akv sequences in DNAs of all tumors. Obviously, the insertion of Akv in a few cells induced the considerably accelerated bone tumor growth. AU - Luz, A. AU - Krump-Konvalinkova, V. AU - Snell, G. AU - Strauss, P.G. AU - Höfler, H. AU - Erfle, V. AU - Schmidt, J. C1 - 27981 C2 - 32888 SP - 265-269 TI - Das murine Leukämievirus Akv wirkt als Promoter der Knochentumorentwicklung fos-transgener Mäuse. JO - Verh. Dtsch. Ges. Pathol. VL - 78 PY - 1994 SN - 0070-4113 ER - TY - JOUR AU - Kunze, F.D. AU - Aubele, M. AU - Burger, G. AU - Haroske, G. AU - Jütting, U. AU - Theissig, F. C1 - 20505 C2 - 13714 SP - S. 445 TI - Prognostische Relevanz und Reproduzierbarkeit der zytometrischen DNA-Bestimmung an Schnittpräparaten von invasiven duktalen Mammakarzinomen. JO - Verh. Dtsch. Ges. Pathol. VL - 76 PY - 1992 SN - 0070-4113 ER - TY - JOUR AU - Dörmer, P. AU - Mergenthaler, H.-G. C1 - 18485 C2 - 11634 SP - 65-74 TI - Die Rolle hämopoetischer Stammzellen und Vorläuferzellen bei Präleukämie. JO - Verh. Dtsch. Ges. Pathol. VL - 74 PY - 1990 SN - 0070-4113 ER - TY - JOUR AB - Cases of myelodysplastic syndrome (MDS) that have evolved into overt leukemia may be retrospectively termed preleukemia. Studies with X-chromosomal markers in females strongly suggest that preleukemia originates from transformation of a very early hemopoietic stem cell. Growth characteristics of myeloblasts in preleukemia indicate that some of the cases already represent early stages of acute leukemia. In other preleukemias clonal evolution towards overt leukemia can be observed. This apparently involves neoplastic transformation of a granulocytic determined progenitor cell. AU - Dörmér, P.G. AU - Mergenthaler, H.G. C1 - 41980 C2 - 0 SP - 65-74 TI - Die Rolle hämopoetischer Stammzellen und Vorläuferzellen bei Präleukämie. JO - Verh. Dtsch. Ges. Pathol. VL - 74 PY - 1990 SN - 0070-4113 ER - TY - JOUR AU - Lanske, B. AU - Hesch, R.-D. AU - Kronenberg, H.M. AU - Atkinson, M.J. C1 - 18610 C2 - 11746 TI - Charakterisierung des Osteosarkom-Phänotyps unter Verwendung der differenziellen Hybridisierung. JO - Verh. Dtsch. Ges. Pathol. PY - 1990 SN - 0070-4113 ER - TY - JOUR AB - To identify genes active in cells of the osteoblast lineage we have begun to characterise the phenotype of the rat osteoblast-like osteosarcoma cell line ROS 17/2.8. We have used the method of differential hybridization to identify cDNA clones encoding mRNA species which are expressed in ROS 17/2.8 cells but not in a non-osteoblast-like osteosarcoma cell line (ROS 25/1). We have identified a number of gene products exhibiting this pattern of expression. AU - Lanske, B.M.K. AU - Hesch -, R.D.D. AU - Kronenberg, H.M. AU - Atkinson, M.J. C1 - 41848 C2 - 0 SP - 363-364 TI - Characterisation of the osteoblastic phenotype by the use of differential hybridization. JO - Verh. Dtsch. Ges. Pathol. VL - 74 PY - 1990 SN - 0070-4113 ER - TY - JOUR AU - Schenck, U. AU - Burger, G. AU - Jütting, U. AU - Schenck, U.B. AU - Schmid, L. AU - Seeleitner, J. C1 - 17706 C2 - 10592 SP - S. 502 TI - Visuelle und bildanalytische Differenzierung von Feinnadelpunktaten bei Mammakarzinomrezidiven nach unterschiedlich langem rezidivfreien Intervall. JO - Verh. Dtsch. Ges. Pathol. VL - 72 PY - 1988 SN - 0070-4113 ER - TY - JOUR AB - Sixteen osteosarcomas of mice, induced by the incorporation of the bone seeking radionuclides 224Ra and 227Th, were studied by electron microscopy. Light microscopically, the tumors showed mainly osteoblastic but also fibroblastic and anaplastic areas. Classification of the osteosarcoma cells in the light microscope was often difficult. Electron microscopically, they showed characteristics of preosteoblasts, osteoblasts, osteocytes, osteoclasts, fibroblasts, fibrocytes or reticulum cells. Undifferentiated cells were also found. The ultrastructure of the different cell types is described. Additionally, the degree and form of mineralization of the osteoid in the bone tumors is studied. The electron microscopic findings indicate that the radiation induced osteosarcomas of mice show a high degree of cellular differentiation. AU - Marquart, K.H. AU - Luz, A. AU - Goessner, W. C1 - 40984 C2 - 40420 SP - 434-437 TI - Zur Ultrastruktur des Strahleninduzierten Osteosakoms der Maus. JO - Verh. Dtsch. Ges. Pathol. VL - Vol. 58 PY - 1974 SN - 0070-4113 ER -