TY  - JOUR
AB  - We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
AU  - van der Laan, C.M.*
AU  - Morosoli-García, J.J.*
AU  - van de Weijer, S.G.A.*
AU  - Colodro-Conde, L.*
AU  - Lupton, M.K.*
AU  - Mitchell, B.L.*
AU  - McAloney, K.*
AU  - Parker, R.*
AU  - Burns, J.M.*
AU  - Hickie, I.B.*
AU  - Pool, R.*
AU  - Hottenga, J.J.*
AU  - Martin, N.G.*
AU  - Medland, S.E.*
AU  - Nivard, M.G.*
AU  - Boomsma, D.I.*
AU  - ACTION Consortium (Thiering, E.)
AU  - ACTION Consortium (Standl, M.)
AU  - ACTION Consortium (Heinrich, J.)
C1  - 63304
C2  - 51260
SP  - 592-606
TI  - Continuity of genetic risk for aggressive behavior across the life-course.
JO  - Behav. Genet.
VL  - 51
IS  - 5
PY  - 2021
SN  - 0001-8244
ER  - 

TY  - JOUR
AU  - Pol-Fuster, J.*
AU  - Canellas, F.*
AU  - Ruiz-Guerra, L.*
AU  - Medina-Dols, A.*
AU  - Bisbal-Carrio, B.*
AU  - Asensio, V.*
AU  - Marzese, D.*
AU  - Llado, J.*
AU  - Olmos, G.*
AU  - Heine-Suner, D.*
AU  - Flaquer, A.
AU  - Vives-Bauza, C.*
C1  - 57622
C2  - 47861
CY  - 233 Spring St, New York, Ny 10013 Usa
SP  - 530-530
TI  - Schizophrenia precipitates as dominant inheritance in a pedigree due to accumulation of rare genomic variants including the DUP3p26.3 and DUP16p23.3 duplications.
JO  - Behav. Genet.
VL  - 49
IS  - 6
PB  - Springer
PY  - 2019
SN  - 0001-8244
ER  - 

TY  - JOUR
AU  - Ip, H.*
AU  - Zafarmand, H.*
AU  - Wedow, R.*
AU  - St Pourcain, B.*
AU  - Alemany, S.*
AU  - Vilor-Tejedor, N.*
AU  - Lundstrom, S.*
AU  - Lu, Y.*
AU  - Chen, Q.*
AU  - Brikell, I.*
AU  - Martin, J.*
AU  - Sugden, K.*
AU  - Prinz, J.*
AU  - Palviainen, T.*
AU  - Loukola, A.*
AU  - Korhonen, T.*
AU  - Vuoksimaa, E.*
AU  - Neumann, A.*
AU  - Bolhuis, K.*
AU  - Thiering, E.
AU  - Standl, M.
AU  - Wills, A.*
AU  - Corley, R.*
C1  - 54741
C2  - 45791
CY  - 233 Spring St, New York, Ny 10013 Usa
SP  - 480-481
TI  - Multivariate GWAMA in over 500k observations on aggressive behavior and ADHD symptoms.
JO  - Behav. Genet.
VL  - 48
IS  - 6
PB  - Springer
PY  - 2018
SN  - 0001-8244
ER  - 

TY  - JOUR
AB  - Transport of glucose into neuronal cells is predominantly mediated by the glucose transporters GLUT1 and GLUT3. In addition, GLUT8 is expressed in some regions of the brain. By in situ hybridization we detected GLUT8-mRNA in hippocampus, thalamus, and cortex. However, its cellular and physiological function is still unknown. Thus, GLUT8 knockout (Slc2a8 -/-) mice were used for a screening approach in the modified hole board (mHB) behavioral test to analyze the role of GLUT8 in the central nervous system. Slc2a8 -/- mice showed increased mean velocity, total distance traveled and performed more turns in the mHB test. This hyperactivity of Slc2a8 -/- mice was confirmed by monitoring locomotor activity in the home cage and voluntary activity in a running wheel. In addition, Slc2a8 -/- mice showed increased arousal as indicated by elevated defecation, reduced latency to the first defecation and a tendency to altered grooming. Furthermore, the mHB test gave evidence that Slc2a8 -/- mice exhibit a reduced risk assessment because they performed less rearings in an unprotected area and showed significantly reduced latency to stretched body posture. Our data suggest that behavioral alterations of Slc2a8 -/- mice are due to dysfunctions in neuronal processes presumably as a consequence of defects in the glucose metabolism.
AU  - Schmidt, S.I.
AU  - Gawlik, V.
AU  - Hölter, S.M.
AU  - Augustin, R.
AU  - Scheepers, A.
AU  - Behrens, M.
AU  - Wurst, W.
AU  - Gailus-Durner, V.
AU  - Fuchs, H.
AU  - Hrabě de Angelis, M.
AU  - Kluge, R.
AU  - Joost, H.G.
AU  - Schürmann, A.
C1  - 1341
C2  - 25433
SP  - 396-406
TI  - Deletion of glucose transporter GLUT8 in mice increases locomotor activity.
JO  - Behav. Genet.
VL  - 38
IS  - 4
PB  - Springer
PY  - 2008
SN  - 0001-8244
ER  - 

TY  - JOUR
AU  - Schröder, J.H.
AU  - Hammerl, P.
C1  - 20646
C2  - 13860
TI  - Social Behavior Differences between XY- and YY-Males of the Guppy Poecilia reticulata Peters (Pisces: Poeciliidae).
JO  - Behav. Genet.
PY  - 1993
SN  - 0001-8244
ER  -