TY  - JOUR
AB  - Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. While descriptions of cells with dendritic morphology in rodent kidneys date back to the early 1970s, a network of DCs in the mouse kidney has only recently been described. DCs acquire distinct phenotypic and functional characteristics depending on the microenvironment and the disease stages. Concomitantly, their communication with cells of the adaptive immunity might have tissue-protective or tissue-deleterious consequences. This review summarizes results from recent studies on the role of DCs in experimental renal inflammation.
AU  - Lindenmeyer, M.*
AU  - Nößner, E.
AU  - Nelson, P.J.*
AU  - Segerer, S.*
C1  - 7465
C2  - 29725
SP  - E83-E90
TI  - Dendritic cells in experimental renal inflammation - Part I.
JO  - Nephron Exp. Nephrol
VL  - 119
IS  - 4
PB  - Karger
PY  - 2011
SN  - 1660-2129
ER  - 

TY  - JOUR
AB  - Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation. In the 1980s and early 1990s, major histocompatibility complex class II antigen- (HLA-DR) positive DCs were first described in normal human kidneys and in the interstitium of kidneys from patients with glomerulonephritis. Several DC subtypes were subsequently distinguished based on their expression of CD1c/BDCA-1, CD141/BDCA-3 and CD209/DC-SIGN (in combination with HLA-DR). These cells were almost exclusively found in the tubulointerstitium, with increased numbers seen during glomerulonephritis. It appears that the human renal tubulointerstitium harbors different DC types which allow the collection of both exogenous as well as endogenous antigens. Plasmacytoid DCs have a plasma cell-like morphology and were commonly found within nodular tubulointerstitial infiltrates. Follicular DCs are rarely seen, but show a predominant localization in organized infiltrates. CD207/langerin is a marker for Langerhans cells. Langerin-positive cells have been found in association with the collecting ducts and urothelium. A functional characterization of these subtypes has been hampered by the difficulty of obtaining samples for analysis. However, these studies are clearly required to define the role of DCs and DC subsets in the pathophysiology of renal disease.
AU  - Nößner, E.
AU  - Lindenmeyer, M.*
AU  - Nelson, P.J.*
AU  - Segerer, S.*
C1  - 7466
C2  - 29726
SP  - E91-E98
TI  - Dendritic cells in human renal inflammation - Part II.
JO  - Nephron Exp. Nephrol
VL  - 119
IS  - 4
PB  - Karger
PY  - 2011
SN  - 1660-2129
ER  - 

TY  - JOUR
AU  - Rathkolb, B.*
AU  - Tran, T.V.*
AU  - Klempt, M.*
AU  - Hrabě de Angelis, M.
AU  - Wanke, R.*
AU  - Wolf, E.*
AU  - Aigner, B.*
C1  - 2759
C2  - 22917
SP  - 143-149
TI  - Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
JO  - Nephron Exp. Nephrol
VL  - 100
PY  - 2005
SN  - 1660-2129
ER  -