TY  - JOUR
AB  - Mitochondrial membrane potential is highly dependent on coupled as well as uncoupled respiration. While brown adipose tissue (BAT) mediates non-shivering thermogenesis (NST), a highly adaptive bioenergetic process critical for energy metabolism, the relationship of coupled and uncoupled respiration in thermogenic adipocytes remains complicated. Uncoupling protein 1 (UCP1)-mediated proton leak is the primary driver of NST, but recent studies have shown that oxidative phosphorylation may be an underappreciated contributor to UCP1-dependent NST. Here, we highlight the role of ATP synthase for BAT thermogenesis and discuss the implications of fine-tuning adrenergic signaling in brown adipocytes by the protein inhibitory factor 1 (IF1). We conclude by hypothesizing future directions for mitochondrial research, such as investigating the potential role of IF1 for mitochondrial substrate preference, structural dynamics, as well as its role in cell fate decision and differentiation.
AU  - Brunetta, H.S.*
AU  - Mori, M.A.*
AU  - Bartelt, A.
C1  - 75085
C2  - 57794
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
TI  - Oxidative phosphorylation in uncoupled mitochondria.
JO  - Bioessays
PB  - Wiley
PY  - 2025
SN  - 0265-9247
ER  - 

TY  - JOUR
AU  - Gómez, A.M.*
AU  - Bartelt, A.
C1  - 68521
C2  - 54693
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
TI  - Endocrine communication of endoplasmic reticulum stress.
JO  - Bioessays
VL  - 45
IS  - 8
PB  - Wiley
PY  - 2023
SN  - 0265-9247
ER  - 

TY  - JOUR
AB  - RNA binding proteins (RBPs) are key factors for the regulation of gene expression by binding to cis elements, i.e. short sequence motifs in RNAs. Recent studies demonstrate that cooperative binding of multiple RBPs is important for the sequence-specific recognition of RNA and thereby enables the regulation of diverse biological activities by a limited set of RBPs. Cross-linking immuno-precipitation (CLIP) and other recently developed high-throughput methods provide comprehensive, genome-wide maps of protein-RNA interactions in the cell. Structural biology gives detailed insights into molecular mechanisms and principles of RNA recognition by RBPs, but has so far focused on single RNA binding proteins and often on single RNA binding domains. The combination of high-throughput methods and detailed structural biology studies is expected to greatly advance our understanding of the code for protein-RNA recognition in gene regulation, as we review in this article.
AU  - Hennig, J.
AU  - Sattler, M.
C1  - 45330
C2  - 37287
CY  - Hoboken
SP  - 899-908
TI  - Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology.
JO  - Bioessays
VL  - 37
IS  - 8
PB  - Wiley-blackwell
PY  - 2015
SN  - 0265-9247
ER  - 

TY  - JOUR
AB  - In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
AU  - Ninkovic, J.
AU  - Götz, M.
C1  - 23374
C2  - 31033
SP  - 242-252
TI  - Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
JO  - Bioessays
VL  - 35
IS  - 3
PB  - Wiley-Blackwell
PY  - 2013
SN  - 0265-9247
ER  - 

TY  - JOUR
AB  - Adult neurogenesis is an exciting and rapidly advancing field of research. It addresses basic biological questions, such as the how and why of de novo neuronal production during adulthood, as well as medically relevant issues, including the potential link between adult neural stem cells and psychiatric disorders, or how stem cell manipulation might be used as a strategy for neuronal replacement. Current research mainly focuses on rodents, but we review here recent examination of non-mammalian vertebrates, which demonstrates that bona fide adult neural stem cells exist in these species. Importantly, especially in teleost fish, these cells can be abundant and located in various brain areas. Hence, non-mammalian vertebrate species provide invaluable comparative material for extracting core mechanisms of adult neural stem cell maintenance and fate.
AU  - Chapouton, P.
AU  - Jagasia, R.
AU  - Bally-Cuif, L.
C1  - 3161
C2  - 24747
SP  - 745-757
TI  - Adult neurogenesis in non-mammalian vertebrates.
JO  - Bioessays
VL  - 29
IS  - 8
PB  - Wiley-Blackwell
PY  - 2007
SN  - 0265-9247
ER  -