TY  - JOUR
AB  - The mixed-valent oxo-bridged ruthenium complex [(HCO2)(NH3)4Ru(μ-O)Ru(NH3)4(O2CH)]3+, known as Ru360, is a selective inhibitor of mitochondrial calcium uptake. Although this compound is useful for studying the role of mitochondrial calcium in biological processes, its widespread availability is limited because of challenges in purification and characterization. Here, we describe our investigations of three different synthetic methods for the preparation of a functional analogue of this valuable compound. We demonstrate that this analogue, isolated from our procedures, exhibits potent mitochondrial calcium uptake inhibitory properties in permeabilized HeLa cells and in isolated mitochondria.
AU  - Nathan, S.R.*
AU  - Pino, N.W.*
AU  - Arduino, D.M.
AU  - Perocchi, F.
AU  - MacMillan, S.N.*
AU  - Wilson, J.J.N.*
C1  - 50844
C2  - 42912
SP  - 3123-3126
TI  - Synthetic methods for the preparation of a functional analogue of Ru360, a potent inhibitor of mitochondrial calcium uptake.
JO  - Inorg. Chem.
VL  - 56
IS  - 6
PY  - 2017
SN  - 0020-1669
ER  - 

TY  - JOUR
AU  - Gailer, J.
AU  - George, G.N.*
AU  - Harris, H.H.*
AU  - Pickering, I.J.*
AU  - Prince, R.C.*
AU  - Somogyi, A.*
AU  - Buttigieg, G.A.*
AU  - Glass, R.S.*
AU  - Denton, M.B.*
C1  - 9648
C2  - 20638
SP  - 5426-5432
TI  - Synthesis, Prification and Structural Characterization of the Dimethyldiselenoarsinate Anion.
JO  - Inorg. Chem.
VL  - 41
PY  - 2002
SN  - 0020-1669
ER  -