TY  - JOUR
AB  - Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro-inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT-signalling pathways in HNECs and has high potential as a broad anti-inflammatory drug that exceeds current indication.
AU  - Steiert, S.A.
AU  - Zissler, U.M.
AU  - Chaker, A.
AU  - Esser-von Bieren, J.
AU  - Dittlein, D.
AU  - Guerth, F.
AU  - Jakwerth, C.A.
AU  - Piontek, G.*
AU  - Zahner, C.*
AU  - Drewe, J.*
AU  - Traidl-Hoffmann, C.
AU  - Schmidt-Weber, C.B.
AU  - Gilles, S.
C1  - 50558
C2  - 42353
CY  - Hoboken
SP  - 388-399
TI  - Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway.
JO  - BioFactors
VL  - 43
IS  - 3
PB  - Wiley
PY  - 2017
SN  - 0951-6433
ER  - 

TY  - JOUR
AB  - Burkitt Lymphoma (BL) cells are highly sensitive to suboptimal growth conditions and undergo apoptosis when seeded at low cell density or reduced serum concentration. Irradiated fibroblasts or a mix of pruvate, alpha -thioglycerol, and bathocuproine disulfonate can protect BL cells from apoptosis induced by lowering cell density or serum concentration by promoting cystine uptake in the cells. The availability of cystine is the limiting factor for glutathione biosynthesis in BL cells and thus for the ability of the cells to cope with oxidative stress. We have set up an expression cloning strategy to clone genes that protect BL cells from apoptosis induced by low cell density and/or serum. Using this approach we have cloned among others the cDNA for Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx).
AU  - Brielmeier, M.
AU  - Bechet, J.-M.*
AU  - Suppmann, S.
AU  - Conrad, M.
AU  - Laux, G.
AU  - Bornkamm, G.W.
C1  - 10335
C2  - 22869
SP  - 179-190
TI  - Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells. 
JO  - BioFactors
VL  - 14
PB  - IOS Press
PY  - 2001
SN  - 0951-6433
ER  -