TY  - JOUR
AB  - INTRODUCTION/AIMS: Swim training and regulation of copper metabolism result in clinical benefits in amyotrophic lateral sclerosis (ALS) mice. Therefore, the study aimed to determine whether swim training improves copper metabolism by modifying copper metabolism in the skeletal muscles of ALS mice. METHODS: SOD1G93A mice (n = 6 per group) were used as the ALS model, and wild-type B6SJL (WT) mice as controls (n = 6). Mice with ALS were analyzed before the onset of ALS (ALS BEFORE), at baseline ALS (first disease symptoms, trained and untrained, ALS ONSET), and at the end of ALS (last stage disease, trained and untrained, ALS TERMINAL). Copper concentrations and the level of copper metabolism proteins in the skeletal muscles of the lower leg were determined. RESULTS: ALS disease caused a reduction in the copper concentration in ALS TERMINAL untrained mice compared with the ALS BEFORE (10.43 ± 1.81 and 38.67 ± 11.50 μg/mg, respectively, p = .0213). The copper chaperon for SOD1 protein, which supplies copper to SOD1, and ATPase7a protein (copper exporter), increased at the terminal stage of disease by 57% (p = .0021) and 34% (p = .0372), while the CTR1 protein (copper importer) decreased by 45% (p = .002). Swim training moderately affected the copper concentration and the concentrations of proteins responsible for copper metabolism in skeletal muscles. DISCUSSION: The results show disturbances in skeletal muscle copper metabolism associated with ALS progression, which is moderately affected by swim training. From a clinical point of view, exercise in water for ALS patients should be an essential element of rehabilitation for maintaining quality of life.
AU  - Białobrodzka, E.*
AU  - Flis, D.J.*
AU  - Akdogan, B.
AU  - Borkowska, A.*
AU  - Wieckowski, M.R.*
AU  - Antosiewicz, J.*
AU  - Zischka, H.
AU  - Dzik, K.P.*
AU  - Kaczor, J.J.*
AU  - Ziolkowski, W.*
C1  - 71615
C2  - 56310
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 1111-1118
TI  - Amyotrophic Lateral Sclerosis and swim training affect copper metabolism in skeletal muscle in a mouse model of disease.
JO  - Muscle Nerve
VL  - 70
IS  - 5
PB  - Wiley
PY  - 2024
SN  - 0148-639X
ER  - 

TY  - JOUR
AB  - Introduction: Magnetic stimulation allows for painless and non-invasive extrinsic motor nerve stimulation. Despite several advantages, the limited coupling to the target reduces the application of magnetic pulses in rehabilitation. According to experience with electrical stimulation, magnetic bursts could remove this constraint. Methods: A novel burst stimulator was used to apply single and burst pulses to the femoral nerve in 10 adult dogs. A figure-of-eight coil was connected, and pulses were applied at 7.5 HZ. Contractions of the quadriceps muscle were measured via an angle force transducer. Results: Muscle forces were significantly higher upon burst stimulation than after single pulses. Four consecutive burst pulses proved most effective. Stimulation by more bursts resulted in fatigue. Conclusion: Burst stimulation is superior to standard magnetic single pulses, and 4 consecutive burst pulses proved most effective. Muscle Nerve, 2012  
AU  - Emrich, D.*
AU  - Fischer, A.*
AU  - Altenhöfer, C.*
AU  - Weyh, T.*
AU  - Helling, F.*
AU  - Goetz, S.*
AU  - Brielmeier, M.
AU  - Matiasek, K.*
C1  - 11202
C2  - 30579
SP  - 954-956
TI  - Muscle force development after low-frequency magnetic burst stimulation in dogs.
JO  - Muscle Nerve
VL  - 46
IS  - 6
PB  - Wiley-Blackwell
PY  - 2012
SN  - 0148-639X
ER  - 

TY  - JOUR
AU  - Vielhaber, S.*
AU  - Jakubiczka, S.
AU  - Schröder, J.M.*
AU  - Sailer, M.*
AU  - Feistner, H.*
AU  - Heinze, H.-J.*
AU  - Wieacker, P.*
AU  - Bettecken, T.
C1  - 22003
C2  - 20547
SP  - 540-548
TI  - Facioscapulohumeral muscular dystrophy with EcoRI/BInI fragment size of more than 32 kb.
JO  - Muscle Nerve
VL  - 25
PY  - 2002
SN  - 0148-639X
ER  -