TY  - JOUR
AB  - Purpose: While metastases directed therapy for oligometastatic disease is recommended in different cancer entities, the treatment of solitary metastases in head and neck squamous cell carcinoma (HNSCC) patients is not clearly defined. Methods: A retrospective analysis was performed on data from 143 HNSCC patients treated between 2001 and 2016 in a tertiary university hospital. Clinical factors and outcome were measured using the median survival of patients receiving metastases specific therapy in comparison with matched control patients. Results: In 37 patients, distant metastases were treated specifically with either surgery and/or stereotactic ablative radiotherapy and had with 23.97 months a more than three times higher median survival than 10 untreated matched controls with potentially treatable distant metastases (7.07 months). Conclusions: Our retrospective analysis demonstrates a significant survival benefit for HNSCC patients who received a specific therapy regarding distant metastasis irrespective of localization as compared to a matched control cohort.
AU  - Schulz, D.M.*
AU  - Wirth, M.A.*
AU  - Piontek, G.*
AU  - Knopf, A.*
AU  - Straube, C.*
AU  - Pigorsch, S.*
AU  - Combs, S.E.
AU  - Pickhard, A.*
C1  - 53259
C2  - 44802
SP  - 1239-1247
TI  - Improved overall survival in head and neck cancer patients after specific therapy of distant metastases.
JO  - Eur. Arch. Otorhinolaryngol.
VL  - 275
IS  - 5
PY  - 2018
SN  - 0937-4477
ER  - 

TY  - JOUR
AB  - Lymph node ratio (LNR) was shown to be a prognostic factor in laryngeal and oral cavity primaries. The purpose of this study was to investigate the impact of the lymph node ratio in oropharyngeal squamous cell carcinoma (OPSCC) with a high incidence of HPV-related disease. Therefore, the role of LNR was evaluated as an additional predictive parameter to the 8th edition of AJCC TNM staging system. From December 2009 to August 2015, patients diagnosed with primary oropharyngeal squamous cell carcinoma were prospectively enrolled. After tumor resection with uni- or bilateral neck dissection, patients with >= 1 nodal metastasis (pN+) were eligible for a retrospective LNR analysis. 137 patients underwent tumor resection with uni- or bilateral neck dissection. The proportion of HPV-associated disease was 42%. Most patients (n = 96; 70%) presented with involved neck nodes. In p16-positive OPSCC, the rate of pN + cases was significantly increased compared to p16-negative OPSCC (86% vs. 58%, p = 0.007). Patients with LNR <= 10% had a significant better overall survival (OS) and disease-specific survival (DSS). However, when stratified for p16-status, LNR <= 10% had a significant impact on OS only for HPV-associated tumors (p = 0.027), whereas LNR of <= 10% was not a significant predictor for better OS in p16-negative OPSCC (p = 0.143). The LNR with a cut-off value of 10% serves as an additional prognostic parameter in HPV-related OPSCC and may help to improve risk stratification in combination with the revised AJCC 8th edition TNM classification.
AU  - Jacobi, C.*
AU  - Rauch, J.*
AU  - Hagemann, J.*
AU  - Lautz, T.*
AU  - Reiter, M.*
AU  - Baumeister, P.
C1  - 52544
C2  - 44065
CY  - New York
SP  - 515-524
TI  - Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status.
JO  - Eur. Arch. Otorhinolaryngol.
VL  - 275
IS  - 2
PB  - Springer
PY  - 2017
SN  - 0937-4477
ER  - 

TY  - JOUR
AB  - Current histological and transmission electron microscopic techniques are insufficient for studying all different aspects of vascular morphology. As a result, we have used scanning electron microscopy (SEM) to examine nasal blood vessels. In our present studies the nasal septa of 15 rabbits were fixed by vascular perfusion, dried by the critical point method and coated with gold for SEM studies. Lower magnifications of specimens using this method show the tissue arrangement in the nasal septum. In higher magnifications the different vessels can be distinguished by their morphological features. The course of the vascular structures can be obverved as well as the junctions between the different vessels. Our results indicate that different morphological techniques must be combined to understand the endonasal vasculature.
AU  - Heinzmann, U.
AU  - Grevers, G.
C1  - 17399
C2  - 9973
TI  - Scanning Electronmicroscope Studies of the Nasal Blood Vessels.
JO  - Eur. Arch. Otorhinolaryngol.
PY  - 1988
SN  - 0937-4477
ER  -