TY  - JOUR
AB  - Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finely tuned by metabolic pathways, transcription factors, and nuclear receptors that control lipid peroxidation levels. Significantly, nutrients such as vitamins and trace elements play a pivotal role in this regulation, directly linking diet and nutrients to cellular fate. This review conveys the latest insights into the metabolic components that influence ferroptosis. We highlight how metabolic and transcriptional regulators and key nutrients, micronutrients, and metabolites orchestrate this process. Charting these interactions will be essential for developing new avenues for therapeutic interventions targeting ferroptosis in various diseases.
AU  - Tschuck, J.
AU  - Skafar, V.*
AU  - Friedmann Angeli, J.P.*
AU  - Hadian, K.
C1  - 74845
C2  - 57633
CY  - 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
SP  - 663-676
TI  - The metabolic code of ferroptosis: Nutritional regulators of cell death.
JO  - Trends Biochem. Sci.
VL  - 50
IS  - 8
PB  - Cell Press
PY  - 2025
SN  - 0376-5067
ER  - 

TY  - JOUR
AB  - Diverse gene regulatory mechanisms impact on immune homeostasis, and a new model now emerges as fundamental in light of recent genome-wide studies. In this picture, transcriptional networks drive functional changes during immune activation, whereas autoregulatory feedback loops of post-transcriptional programs ensure the original cell lineage identity and subsequent immune resolution.
AU  - Lichti, J.
AU  - Gallus, C.
AU  - Glasmacher, E.
C1  - 52473
C2  - 44009
CY  - London
SP  - 1-4
TI  - Immune responses - Transcriptional and post-transcriptional networks pass the baton.
JO  - Trends Biochem. Sci.
VL  - 43
IS  - 1
PB  - Elsevier Science London
PY  - 2018
SN  - 0376-5067
ER  - 

TY  - JOUR
AB  - Low-complexity (LC) domains regulate the aggregation and phase transition of proteins in a modification-dependent manner. The study of LC domain modifications has now become feasible, as shown by genetic variants of the carboxy-terminal domain (CTD) of RNA Polymerase II (Pol II) that provide access to the type and position of modifications of a LC domain by mass spectrometry (MS).
AU  - Schüller, R.
AU  - Eick, D.
C1  - 48790
C2  - 41337
CY  - London
SP  - 894-897
TI  - Getting access to low-complexity domain modifications.
JO  - Trends Biochem. Sci.
VL  - 41
IS  - 11
PB  - Elsevier Science London
PY  - 2016
SN  - 0376-5067
ER  - 

TY  - JOUR
AB  - Metabolism of foreign chemicals (xenobiotics) by plants generally proceeds in three phases: transformation, conjugation and compartmentation. The participating enzymes have numerous similarities not only to the enzymes of normal secondary plant metabolism, but also to those of xenobiotic metabolism in mammalian liver. Plants may therefore be considered as a 'green liver', acting as an important global sink for environmental chemicals.
AU  - Sandermann, H.J.
C1  - 40530
C2  - 38719
SP  - 82-84
TI  - Plant metabolism of xenobiotics.
JO  - Trends Biochem. Sci.
VL  - 17
IS  - 2
PY  - 1992
SN  - 0376-5067
ER  -