TY  - JOUR
AB  - Background. Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.Aim. To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa.Methods. In this pilot study, measurements of lesional and perilesional buccal and mouth floor mucosa were conducted in vivo with a TRFS system. Histopathological findings were consistent with OLP in 8 out of 10 patients biopsied. Two patients with histopathological diagnoses of frictional hyperkeratosis and oral candidiasis, respectively, were excluded from the study.Results. Our preliminary data show that lifetime values in the 360-560 nm spectral range indicate a significant differentiation between normal and diseased tissue. In contrast to the standard oral biopsy procedure, this technique is noninvasive, painless, time-efficient and safe.Conclusions. Future studies are needed to better elucidate the diagnostic capability of TRFS and to further explore the sources of fluorescence contrast. This pilot study suggests that, based on fluorescence lifetime parameters, TRFS is a very promising technology for the development of a novel OLP diagnostic technique.
AU  - Gorpas, D.
AU  - Davari, P.*
AU  - Bec, J.*
AU  - Fung, M.A.*
AU  - Marcu, L.*
AU  - Farwell, D.G.*
AU  - Fazel, N.*
C1  - 52988
C2  - 44333
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 546-552
TI  - Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.
JO  - Clin. Exp. Dermatol.
VL  - 43
IS  - 5
PB  - Wiley
PY  - 2018
SN  - 0307-6938
ER  - 

TY  - JOUR
AB  - Vibratory angio-oedema is a rare form of physical urticaria characterized by pruriginous weals and angio-oedema at the site of exposure to vibration. Severe treatment-resistant disease can occur, and is associated with significant disability. Therapy with omalizumab, a monoclonal IgG anti-IgE antibody, has been shown to be successful in several types of physical urticaria. We report a patient with vibratory angio-oedema for whom all standard treatments for urticaria, including omalizumab, failed to show a clinical benefit. Finally, ketotifen was tried, and unexpectedly reduced symptoms significantly. Ketotifen may thus represent a therapeutic option in patients with treatment-resistant vibratory angio-oedema.
AU  - Pressler, A.*
AU  - Grosber, M.
AU  - Halle, M.*
AU  - Ring, J.
AU  - Brockow, K.
C1  - 23383
C2  - 31032
SP  - 151-153
TI  - Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.
JO  - Clin. Exp. Dermatol.
VL  - 38
IS  - 2
PB  - Wiley-Blackwell
PY  - 2013
SN  - 0307-6938
ER  - 

TY  - JOUR
AB  - BACKGROUND: Previous studies have reported a protective association between high levels of exposure to endotoxin during infancy and the development of subsequent eczema within the first 6 months of life. AIM: To investigate the association between exposure in infancy to endotoxin from mattress dust and the development of eczema up to age of 6 years in 2166 children participating in the German Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood (LISA) study, an ongoing population-based birth-cohort study. METHODS: Endotoxin levels in house dust samples collected at 3 months after birth were quantified using the kinetic Limulus amebocyte lysate assay. Specific IgE antibodies to common food and aeroallergens were measured using radioallergosorbent test, fluorenzyme immunoassay (Pharmacia CAP system) when children were 2 and 6 years old. Information on eczema symptoms and physician-diagnosed eczema were collected at each follow-up using a questionnaire. RESULTS: No association was found between endotoxin exposure from mattresses (the mattresses of each child and their parents were examined) during infancy and the development of eczema symptoms or doctor-diagnosed eczema by 6 years of age (OR = 1.1, 95% CI 0.5-2.3, and OR = 1.1, 95% CI 0.4-3.3, respectively). No association was found when children with only atopic eczema. CONCLUSION: Endotoxin exposure during infancy is unlikely to have a large long-term effect on the development of eczema, especially the atopic form.
AU  - Chen, C.-M.
AU  - Sausenthaler, S.
AU  - Bischof, W.*
AU  - Herbarth, O.*
AU  - Borte, M.*
AU  - Behrendt, H.
AU  - Krämer, U.*
AU  - Williams, H.C.*
AU  - Wichmann, H.-E.
AU  - Heinrich, J.
C1  - 582
C2  - 27354
SP  - 238-244
TI  - Perinatal exposure to endotoxin and the development of eczema during the first 6 years of life.
JO  - Clin. Exp. Dermatol.
VL  - 35
IS  - 3
PB  - British Assoc. of Dermatologists
PY  - 2010
SN  - 0307-6938
ER  -