TY  - JOUR
AB  - Background Differentiation between irritant and allergic skin reactions in epicutaneous patch testing is based largely on subjective clinical criteria, with the risk of high intraobserver and interobserver variability. Novel dermatological imaging using optoacoustic mesoscopy allows quantitative three-dimensional assessment of microvascular biomarkers.Objectives We investigated the potential of optoacoustic imaging to improve the precision of patch test evaluation.Methods Sixty-nine test reactions and 48 healthy skin sections in 52 patients with suspected type IV allergy were examined using raster-scan optoacoustic mesoscopy.Results We identified biomarkers from the optoacoustic images. Allergic reactions were associated with higher fragmentation of skin vasculature than irritant reactions (19.5 +/- 9.7 vs 14.3 +/- 3.7 fragments/100 pixels(2); P < .05), as well as lower ratio of low- to high-frequency acoustic signals (1.6 +/- 0.5 vs 2.0 +/- 0.6, P < .05). Allergic reactions graded "++" showed higher vessel fragmentation than reactions graded "+" (25.4 +/- 13.2 vs 17.1 +/- 6.5 fragments/100 pixels(2); P < .05). A linear model combining the biomarkers fragmentation and frequency ratio could differentiate allergic from irritant test reactions with an area under the receiving operator characteristic curve of 0.80 (95% confidence interval 0.64-0.91), reaching a sensitivity of 81% and specificity of 63%.Conclusions Optoacoustic mesoscopy shows potential to help in differentiating between allergic and irritant test reactions based on novel biomarkers that may reflect vasodilation, vessel tortuosity, and edema.
AU  - Hindelang, B.
AU  - Aguirre Bueno, J.
AU  - Berezhnoi, A.
AU  - He, H.
AU  - Eyerich, K.*
AU  - Ntziachristos, V.
AU  - Biedermann, T.*
AU  - Darsow, U.*
C1  - 58877
C2  - 48410
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 206-214
TI  - Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing.
JO  - Contact Dermatitis
VL  - 83
IS  - 3
PB  - Wiley
PY  - 2020
SN  - 0105-1873
ER  - 

TY  - JOUR
AB  - no Abstract
AU  - Willi, R.*
AU  - Pfab, F.
AU  - Zilker, T.*
AU  - Buters, J.
AU  - Schalock, P.*
AU  - Huss-Marp, J.
AU  - Todorova, A.*
AU  - Ring, J.
AU  - Darsow, U.
C1  - 6392
C2  - 28602
SP  - 361-362
TI  - Danger from the workplace: Allergic contact dermatitis from the first exposure to isothiazolinones.
JO  - Contact Dermatitis
VL  - 64
IS  - 6
PB  - Wiley-Blackwell
PY  - 2011
SN  - 0105-1873
ER  - 

TY  - JOUR
AB  - Nickel is one of the most prevalent causes of contact allergy in the general population. This study focuses on human exposure to airborne nickel and its potential to induce allergic sensitization. The study group consisted of 309 children at school-starter age living in the West of Germany in the vicinity of two industrial sources and in a rural town without nearby point sources of nickel. An exposure assessment of nickel in ambient air was available for children in the Ruhr district using routinely monitored ambient air quality data and dispersion modelling. Internal nickel exposure was assessed by nickel concentrations in morning urine samples of the children.The observed nickel sensitization prevalence rates varied between 12.6% and 30.7%. Statistically significant associations were showed between exposure to nickel in ambient air and urinary nickel concentration as well as between urinary nickel concentration and nickel sensitization. Furthermore, an elevated prevalence of nickel sensitization was associated with exposure to increased nickel concentrations in ambient air. The observed associations support the assumption that inhaled nickel in ambient air might be a risk factor for nickel sensitization; further studies in larger collectives are necessary.
AU  - Mann, E.*
AU  - Ranft, U.*
AU  - Eberwein, G.*
AU  - Gladtke, D.*
AU  - Sugiri, D.*
AU  - Behrendt, H.
AU  - Ring, J.
AU  - Schäfer, T.*
AU  - Begerow, J.*
AU  - Wittsiepe, J.*
AU  - Krämer, U.*
AU  - Wilhelm, M.*
C1  - 4141
C2  - 27886
SP  - 355-362
TI  - Does airborne nickel exposure induce nickel sensitization?
JO  - Contact Dermatitis
VL  - 62
IS  - 6
PB  - Munksgaard
PY  - 2010
SN  - 0105-1873
ER  - 

TY  - JOUR
AB  - BACKGROUND: Exposure to contact allergens and specific allergic sensitization to them are common, but possible related health effects have been rarely studied. OBJECTIVES: We aimed to analyse possible associations between contact sensitization to nickel sulfate and fragrance mix I and lung function parameters or bronchial hyper-responsiveness. METHODS: Within a population-based study in Augsburg, 1052 adults performed lung function tests, including forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC) and bronchial hyper-responsiveness (BHR). Patch tests were performed, and information was assessed by medical examinations and interviews. Logistic regression models were applied to study associations between contact allergies and lung function parameters. RESULTS: Women were sensitized significantly more often than men to nickel [odds ratio (OR) 3.97, 95% confidence interval (CI) 2.50-6.29] and fragrance mix I (OR 2.28, 95% CI 1.50-3.46). Patch test results for nickel and fragrance mix I did not influence mean FEV(1) and FVC % predicted values. However, in women, a higher rate of BHR was associated with positive patch test reactions to fragrance mix I (OR 2.24, 95% CI 1.11-4.52). CONCLUSIONS: Contact sensitization to fragrance mix I is associated with a higher rate of BHR in women. Thus, in women with contact allergy to fragrances, airway obstruction should be considered as a possible co-morbidity.
AU  - Schnabel, E.
AU  - Schoefer, Y.
AU  - Chen, C.M.
AU  - Schäfer, T.
AU  - Behrendt, H.*
AU  - Ring, J.
AU  - Wichmann, H.-E.
AU  - Heinrich, J.
C1  - 5756
C2  - 27461
SP  - 157-163
TI  - Sensitization to contact allergens and bronchial hyper-responsiveness.
JO  - Contact Dermatitis
VL  - 63
IS  - 3
PB  - Wiley-Blackwell Publishing
PY  - 2010
SN  - 0105-1873
ER  - 

TY  - JOUR
AB  - Erythema multiforme is a relatively common skin disorder. The best known cause is herpes simplex virus infection. We report the first case of erythema multiforme due to contact with laurel oil. The diagnosis was confirmed by the positive patch test to laurel oil, the histopathological studies of the lesions and the histopathological studies of the positive patch test to laurel oil.
AU  - Athanasiadis, G.I.*
AU  - Pfab, F.
AU  - Klein, A.
AU  - Braun-Falco, M.
AU  - Ring, J.*
AU  - Ollert, M.
C1  - 762
C2  - 24903
SP  - 116-118
TI  - Erythema multiforme due to contact with laurel oil.
JO  - Contact Dermatitis
VL  - 57
IS  - 2
PB  - Blackwell
PY  - 2007
SN  - 0105-1873
ER  -