TY  - JOUR
AU  - Goos, T.*
AU  - Dubbeldam, A.*
AU  - Vermant, M.*
AU  - Gogaert, S.*
AU  - De Sadeleer, L.J.
AU  - De Crem, N.*
AU  - De Langhe, E.*
AU  - Yserbyt, J.*
AU  - Weynand, B.*
AU  - Carlon, M.S.*
AU  - Verschakelen, J.*
AU  - Vermeer, S.*
AU  - Verleden, S.E.*
AU  - Wuyts, W.A.*
C1  - 68113
C2  - 54591
CY  - Radarweg 29, 1043 Nx Amsterdam, Netherlands
SP  - 1476-1480
TI  - Intrafamilial correlation and variability in the clinical evolution of pulmonary fibrosis.
JO  - Chest
VL  - 164
IS  - 6
PB  - Elsevier
PY  - 2023
SN  - 0012-3692
ER  - 

TY  - JOUR
AU  - Rathnayake, S.N.H.*
AU  - Ditz, B.*
AU  - Willemse, B.W.M.*
AU  - Timens, W.*
AU  - Kooistra, W.*
AU  - Heijink, I.H.*
AU  - Oliver, B.G.G.*
AU  - van den Berge, M.*
AU  - Faiz, A.*
AU  - National Heart, Lung, and Blood Institute LungMAP Consortium (Aliee, H.)
AU  - National Heart, Lung, and Blood Institute LungMAP Consortium (Theis, F.J.)
C1  - 70202
C2  - 55058
CY  - Radarweg 29, 1043 Nx Amsterdam, Netherlands
SP  - 85-89
TI  - Longitudinal effects of 1-year smoking cessation on human bronchial epithelial transcriptome.
JO  - Chest
VL  - 164
IS  - 1
PB  - Elsevier
PY  - 2023
SN  - 0012-3692
ER  - 

TY  - JOUR
AB  - BACKGROUND: Abnormal weights, e.g. Obesity, has shown strong modifying effect on the association between air pollution exposure and lung function impairment in adults. RESEARCH QUESTIONS: How may weight status modify the effects of long-term air pollution on adolescents' lung function, particularly in areas with pollution levels much lower than the current EU air quality standards? STUDY DESIGN AND METHODS: In this observational study, we investigated 2224 adolescents from the German GINIplus/LISA birth cohorts. Lung function was measured at age 15 years. Under, normal and over/obese weights were defined using percentiles of body mass index. Average concentrations of air pollution were modelled at residential addresses at four exposure windows between 0-15 years. Multivariable linear regression models were fitted by weight group on lung function with exposure at each window or cumulative exposure since birth. RESULTS: The median air pollution concentrations were half to two-thirds of the EU standards. Significant associations were observed only for individuals with under and over/obese weights. For example, per interquartile range increase in nitrogen dioxide at the 15th-year exposure window, the forced expiratory volume in one second (FEV1) declined by -2.9% [95% confidence interval (CI): -5.2 to -0.5%] for underweight group and -3.4% (95%CI: -5.4 to -1.2%) for over/obese weight group. Similarly, longer exposure to moderate-level air pollution since birth was significantly associated with lung function impairment for groups with abnormal weights. INTERPRETATION: Exposure to low-to-moderate levels of air pollution was associated with lung function impairment for adolescents with abnormal weights. Longer exposure aggravated the adverse effect. Whether there may be critical exposure window since birth warrants further exploration.
AU  - Zhao, Q.*
AU  - Kress, S.*
AU  - Markevych, I.*
AU  - Berdel, D.*
AU  - von Berg, A.*
AU  - Gappa, M.*
AU  - Koletzko, S.*
AU  - Bauer, C.P.*
AU  - Schulz, H.
AU  - Standl, M.
AU  - Heinrich, J.*
AU  - Schikowski, T.*
C1  - 61302
C2  - 50117
CY  - Radarweg 29, 1043 Nx Amsterdam, Netherlands
SP  - 249-258
TI  - Long-term air pollution exposure under EU limits and adolescents' lung function: Modifying effect of abnormal weight in GINIplus/LISA birth cohorts.
JO  - Chest
VL  - 160
IS  - 1
PB  - Elsevier
PY  - 2021
SN  - 0012-3692
ER  - 

TY  - JOUR
AB  - The incidence of pleural infection has been rising in recent years. Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has significantly reduced the need of surgery and its impact on clinical care is rising worldwide. Efforts are underway to optimize the delivery regime and establish the short and longer term effects of this therapy. The complex interactions of bacterial infection within the pleura with inflammatory responses and clinical interventions (antibiotics and tPA/DNase) require further studies to improve future treatment options. Intrapleural instillation of tPA potently induces pleural fluid formation, principally via a monocyte chemotactic protein (MCP)-1 dependent mechanism. Activation of transcriptional programs in pleural resident cells and infiltrating cells during pleural infection and malignancy results in the local secretion of a cocktail of pro-inflammatory signalling molecules (including MCP-1) within the pleural confines that contributes to effusion formation. Understanding the biology of these molecules and their interaction may provide novel targets for pleural fluid control.
AU  - Lee, Y.C.*
AU  - Idell, S.*
AU  - Stathopoulos, G.T.
C1  - 49264
C2  - 41768
CY  - Glenview
SP  - 1361-1370
TI  - Translational research in pleural infection and beyond.
JO  - Chest
VL  - 150
IS  - 6
PB  - Amer Coll Chest Physicians
PY  - 2016
SN  - 0012-3692
ER  - 

TY  - JOUR
AU  - Radon, K.*
AU  - Büsching, K.*
AU  - Heinrich, J.
AU  - Wichmann, H.-E.
AU  - Jörres, R.A.*
AU  - Magnussen, H.*
AU  - Nowak, D.*
C1  - 22079
C2  - 20726
SP  - 1086-1090
TI  - Passive Smoking Exposure : A Risk Factor for Chronic Bronchitis and Asthma in Adults ?.
JO  - Chest
VL  - 122
PY  - 2002
SN  - 0012-3692
ER  - 

TY  - JOUR
AB  - An aerosol with particles aerodynamically larger than 0.5 μm inspired through the nose is partially filtered in the nasal passages by inertial transport. Mouth-inspiration aerosols in the aerodynamic size range between 0.5 and 2 μm penetrate without particle losses to the alveolar region where they are partially filtered by gravitational sedimentation. Aerosols with larger particles inspired through the mouth experience partial collection by inertial impaction in the extrathoracic airways and by gravitational sedimentation and inertial impaction in the bronchial airways before effective filtration in the alveolated air-spaces due to gravitational sedimentation. Particles larger than 12 μm cannot penetrate to the alveolar region. With mouth-breathing particles more readily escape deposition in the extrathoracic and bronchial airways during expiration than during inspiration. Present knowledge tells us neither the smallest particle effectively transported by gravitational sedimentation in the respiratory tract nor the effectiveness there of diffusional transport.
AU  - Heyder, J.
C1  - 41624
C2  - 40431
SP  - 820-823
TI  - Mechanisms of aerosol particle deposition.
JO  - Chest
VL  - 80
IS  - 6 Suppl.
PY  - 1981
SN  - 0012-3692
ER  -