TY - JOUR AB - BACKGROUND: Current measures of adiposity have limitations. Artificial intelligence (AI) models may accurately and efficiently estimate body composition (BC) from routine imaging. OBJECTIVE: To assess the association of AI-derived BC compartments from magnetic resonance imaging (MRI) with cardiometabolic outcomes. DESIGN: Prospective cohort study. SETTING: UK Biobank (UKB) observational cohort study. PARTICIPANTS: 33 432 UKB participants with no history of diabetes, myocardial infarction, or ischemic stroke (mean age, 65.0 years [SD, 7.8]; mean body mass index [BMI], 25.8 kg/m2 [SD, 4.2]; 52.8% female) who underwent whole-body MRI. MEASUREMENTS: An AI tool was applied to MRI to derive 3-dimensional (3D) BC measures, including subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), and SM fat fraction (SMFF), and then calculate their relative distribution. Sex-stratified associations of these relative compartments with incident diabetes mellitus (DM) and major adverse cardiovascular events (MACE) were assessed using restricted cubic splines. RESULTS: Adipose tissue compartments and SMFF increased and SM decreased with age. After adjustment for age, smoking, and hypertension, greater adiposity and lower SM proportion were associated with higher incidence of DM and MACE after a median follow-up of 4.2 years in sex-stratified analyses; however, after additional adjustment for BMI and waist circumference (WC), only elevated VAT proportions and high SMFF (top fifth percentile in the cohort for each) were associated with increased risk for DM (respective adjusted hazard ratios [aHRs], 2.16 [95% CI, 1.59 to 2.94] and 1.27 [CI, 0.89 to 1.80] in females and 1.84 [CI, 1.48 to 2.27] and 1.84 [CI, 1.43 to 2.37] in males) and MACE (1.37 [CI, 1.00 to 1.88] and 1.72 [CI, 1.23 to 2.41] in females and 1.22 [CI, 0.99 to 1.50] and 1.25 [CI, 0.98 to 1.60] in males). In addition, in males only, those in the bottom fifth percentile of SM proportion had increased risk for DM (aHR for the bottom fifth percentile of the cohort, 1.96 [CI, 1.45 to 2.65]) and MACE (aHR, 1.55 [CI, 1.15 to 2.09]). LIMITATION: Results may not be generalizable to non-Whites or people outside the United Kingdom. CONCLUSION: Artificial intelligence-derived BC proportions were strongly associated with cardiometabolic risk, but after BMI and WC were accounted for, only VAT proportion and SMFF (both sexes) and SM proportion (males only) added prognostic information. PRIMARY FUNDING SOURCE: None. AU - Jung, M.* AU - Reisert, M.* AU - Rieder, H.* AU - Rospleszcz, S. AU - Lu, M.T.* AU - Bamberg, F.* AU - Raghu, V.K.* AU - Weiss, J.* C1 - 75672 C2 - 58164 CY - Independence Mall West 6th And Race St, Philadelphia, Pa 19106-1572, United States TI - Association between body composition and cardiometabolic outcomes : A prospective cohort study. JO - Ann. Intern. Med. PB - Amer Coll Physicians PY - 2025 SN - 0003-4819 ER - TY - JOUR AU - Eigentler, T.* AU - Lomberg, D.* AU - Machann, J. AU - Stefan, N. C1 - 59741 C2 - 49030 CY - Independence Mall West 6th And Race St, Philadelphia, Pa 19106-1572 Usa SP - 836-837 TI - Lipodystrophic nonalcoholic fatty liver disease induced by immune checkpoint blockade. JO - Ann. Intern. Med. VL - 172 IS - 12 PB - Amer Coll Physicians PY - 2020 SN - 0003-4819 ER - TY - JOUR AU - Mascalzoni, D.* AU - Bentzen, H.B.* AU - Budin-Ljøsne, I.* AU - Bygrave, L.A.* AU - Bell, J.* AU - Dove, E.S.* AU - Fuchsberger, C.* AU - Hveem, K.* AU - Mayrhofer, M.T.* AU - Meraviglia, V.* AU - O'Brien, D.R.* AU - Pattaro, C.* AU - Pramstaller, P.P.* AU - Rakic, V.* AU - Rossini, A.* AU - Shabani, M.* AU - Svantesson, D.J.B.* AU - Tomasi, M.* AU - Ursin, L.* AU - Wjst, M. AU - Kaye, J.* C1 - 55527 C2 - 46651 CY - Independence Mall West 6th And Race St, Philadelphia, Pa 19106-1572 Usa SP - 332-335 TI - Are requirements to deposit data in research repositories compatible with the european union's general data protection regulation? JO - Ann. Intern. Med. VL - 170 IS - 5 PB - Amer Coll Physicians PY - 2019 SN - 0003-4819 ER - TY - JOUR AB - Background: Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. Objective: To evaluate the effects of acupuncture in patients with SAR. Design: Randomized, controlled multicenter trial. (ClinicalTrials.gov:NCT00610584) Setting: 46 specialized physicians in 6 hospital clinics and 32 private outpatient clinics. Patients: 422 persons with SAR and IgE sensitization to birch and grass pollen. Intervention: Acupuncture plus rescue medication (RM) (cetirizine) (n = 212), sham acupuncture plus RM (n = 102), or RM alone (n = 108). Twelve treatments were provided over 8 weeks in the first year. Measurements: Changes in the Rhinitis Quality of Life Questionnaire (RQLQ) overall score and the RM score (RMS) from baseline to weeks 7 and 8 and week 16 in the first year and week 8 in the second year after randomization, with predefined noninferiority margins of -0.5 point (RQLQ) and -1.5 points (RMS). Results: Compared with sham acupuncture and with RM, acupuncture was associated with improvement in RQLQ score (sham vs. acupuncture mean difference, 0.5 point [97.5% CI, 0.2 to 0.8 point; P < 0.001]; RM vs. acupuncture mean difference, 0.7 point [97.5% CI, 0.4 to 1.0 point; P < 0.001]) and RMS (sham vs. acupuncture mean difference, 1.1 points [97.5% CI, 0.4 to 1.9 points; P < 0.001]; RM vs. acupuncture mean difference, 1.5 points [97.5% CI, 0.8 to 2.2 points; P < 0.001]). There were no differences after 16 weeks in the first year. After the 8-week follow-up phase in the second year, small improvements favoring real acupuncture over the sham procedure were noted (RQLQ mean difference, 0.3 point [95% CI, 0.03 to 0.6 point; P = 0.032]; RMS mean difference, 1.0 point [95% CI, 0.2 to 1.9 points; P = 0.018]). Limitation: The study was not powered to detect rare adverse events, and the RQLQ and RMS values were low at baseline. Conclusion: Acupuncture led to statistically significant improvements in disease-specific quality of life and antihistamine use measures after 8 weeks of treatment compared with sham acupuncture and with RM alone, but the improvements may not be clinically significant. AU - Brinkhaus, B.* AU - Ortiz, M.* AU - Witt, C.M.* AU - Roll, S.* AU - Linde, K.* AU - Pfab, F. AU - Niggemann, B.* AU - Hummelsberger, J.* AU - Treszl, A.* AU - Ring, J.* AU - Zuberbier, T.* AU - Wegscheider, K.* AU - Willich, S.N.* C1 - 23524 C2 - 31206 SP - 225-234 TI - Acupuncture in patients with seasonal allergic rhinitis: A randomized trial. JO - Ann. Intern. Med. VL - 158 IS - 4 PB - Amer. Coll. Physicians PY - 2013 SN - 0003-4819 ER -