TY  - JOUR
AB  - Cationic polymers are known to efficiently deliver nucleic acids to target cells by encapsulating the cargo into nanoparticles. However, the molecular organization of these nanoparticles is often not fully explored. Yet, this information is crucial to understand complex particle systems and the role influencing factors play at later stages of drug development. Coarse-grained molecular dynamics (CG-MD) enables modeling of systems that are the size of real nanoparticles, providing meaningful insights into molecular interactions between polymers and nucleic acids. Herein, the particle assembly of variations of an amphiphilic poly(beta-amino ester) (PBAE) with siRNA was simulated to investigate the influence of factors such as polymer lipophilicity and buffer conditions on the nanoparticle structure. Simulations were validated by wet lab methods including nuclear magnetic resonance (NMR) and align well with experimental findings. Therefore, this work emphasizes that CG-MD simulations can provide underlying explanations of experimentally observed nanoparticle properties by visualizing the nanoscale structure of polyplexes.
AU  - Steinegger, K.M.*
AU  - Allmendinger, L.*
AU  - Sturm, S.*
AU  - Sieber-Schäfer, F.*
AU  - Kromer, A.P.E.*
AU  - Muller-Caspary, K.*
AU  - Winkeljann, B.*
AU  - Merkel, O.M.
C1  - 72612
C2  - 56720
CY  - 1155 16th St, Nw, Washington, Dc 20036 Usa
SP  - 15683-15692
TI  - Molecular dynamics simulations elucidate the molecular organization of poly(beta-amino ester) based polyplexes for siRNA delivery.
JO  - Nano Lett.
VL  - 24
IS  - 49
PB  - Amer Chemical Soc
PY  - 2024
SN  - 1530-6984
ER  - 

TY  - JOUR
AB  - The pursuit of miniaturized optical sources for on-chip applications has led to the development of surface plasmon polariton lasers (plasmonic lasers). While applications in spectroscopy and information technology would greatly benefit from the facile and active tuning of the output wavelength from such devices, this topic remains underexplored. Here, we demonstrate optically controlled switching between predefined wavelengths within a plasmonic microlaser. After fabricating Fabry-Pérot plasmonic cavities that consist of two curved block reflectors on an ultrasmooth flat Ag surface, we deposit a thin film of CdSe/CdxZn1-xS/ZnS colloidal core/shell/shell nanoplatelets (NPLs) as the gain medium. Our cavity geometry allows the spatial and energetic separation of transverse modes. By spatially modulating the gain profile within this device, we demonstrate active selection and switching between four transverse modes within a single plasmonic laser. The fast buildup and decay of the plasmonic modes promises picosecond switching times, given sufficiently rapid changes in the structured illumination.
AU  - Keitel, R.C.*
AU  - Aellen, M.*
AU  - Feber, B.L.*
AU  - Rossinelli, A.A.*
AU  - Meyer, S.A.*
AU  - Cui, J.
AU  - Norris, D.J.*
C1  - 63426
C2  - 51430
CY  - 1155 16th St, Nw, Washington, Dc 20036 Usa
SP  - 8952–8959
TI  - Active mode switching in plasmonic microlasers by spatial control of optical gain.
JO  - Nano Lett.
VL  - 21
IS  - 21
PB  - Amer Chemical Soc
PY  - 2021
SN  - 1530-6984
ER  - 

TY  - JOUR
AB  - Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor.
AU  - Dicheva, B.M.*
AU  - Hagen, T.L.*
AU  - Li, L.*
AU  - Schipper, D.*
AU  - Seynhaeve, A.L.*
AU  - Rhoon, G.C.*
AU  - Eggermont, A.M.*
AU  - Lindner, L.H.
AU  - Koning, G.A.*
C1  - 26122
C2  - 32080
SP  - 2324-2331
TI  - Cationic thermosensitive liposomes: A novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells.
JO  - Nano Lett.
VL  - 13
IS  - 6
PB  - Amer. Chemical Soc.
PY  - 2013
SN  - 1530-6984
ER  -