TY  - JOUR
AB  - BACKGROUND: Frailty, resilience and intrinsic capacity (IC) are concepts to evaluate older person`s health status, but no comparison of their associations with adverse health outcomes exists. We therefore aimed to assess which concept is most useful for determining long-term health of older adults. METHODS: Analyses were based on the KORA (Cooperative Health Research in the Region of Augsburg)-Age study (n = 940, 65-93 years). Frailty was evaluated using the physical frailty-phenotype by Fried et al. For comparability to resilience and IC, we chose the protective concept of robustness instead of frailty in the present analysis. Resilience was measured by the 11-item resilience-scale. The IC-score was based on 4 domains (locomotion, cognition, vitality and psychiatric capacities). Associations with falls, disability, and hospitalization at 3-year and 7-year follow-up and with mortality were evaluated by multivariable adjusted logistic and Cox regression. Concept overlaps were illustrated by a Venn-diagram. RESULTS: In the fully adjusted models, robustness showed significant inverse associations with most outcomes (3-year follow-up: OR (95%CI): disability 0.448 (0.300-0.668), 7-year follow-up: falls 0.477 (0.298-0.764), hospitalization 0.547 (0.349-0.856), and all-cause mortality 0.649 (0.460-0.915)) while resilience and IC showed significant inverse associations with disability only (e.g., 7-year-follow-up: resilience: 0.467 (0.304-0.716), IC: 0.510 (0.329-0.793)). 23% of the participants met the criteria for both robustness and IC while 22% met those for robustness and resilience. CONCLUSION: Robustness was the most useful concept, showing the strongest protective associations for most adverse health outcomes. IC and resilience showed their main strengths in capturing protective associations for disabilities. Robustness overlapped with resilience and IC, supporting the concept of mind-body-interaction.
AU  - Rippl, M.*
AU  - Huemer, M.-T.
AU  - Schwettmann, L.
AU  - Grill, E.*
AU  - Peters, A.
AU  - Drey, M.*
AU  - Thorand, B.
C1  - 72687
C2  - 56699
CY  - Ste 800, 230 Park Ave, New York, Ny 10169 Usa
TI  - Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study.
JO  - J. Nutr. Health Aging
VL  - 29
IS  - 1
PB  - Elsevier Science Inc
PY  - 2025
SN  - 1279-7707
ER  - 

TY  - JOUR
AB  - The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
AU  - Bousquet, J.*
AU  - Bewick, M.*
AU  - Cano, A.*
AU  - Eklund, P.*
AU  - Fico, G.*
AU  - Goswami, N.*
AU  - Guldemond, N.A.*
AU  - Henderson, D.W.*
AU  - Hinkema, M.J.*
AU  - Liotta, G.*
AU  - Mair, A.*
AU  - Molloy, W.*
AU  - Monaco, A.P.*
AU  - Monsonis-Paya, I.*
AU  - Nizinska, A.*
AU  - Papadopoulos, H.*
AU  - Pavlickova, A.*
AU  - Pecorelli, S.*
AU  - Prados-Torres, A.*
AU  - Roller-Wirnsberger, R.E.*
AU  - Somekh, D.*
AU  - Vera-Muñoz, C.*
AU  - Visser, F.*
AU  - Farrell, J.*
AU  - Malva, J.*
AU  - Andersen Ranberg, K.*
AU  - Camuzat, T.*
AU  - Carriazo, A.M.*
AU  - Crooks, G.*
AU  - Gutter, Z.*
AU  - Iaccarino, G.*
AU  - de Keenoy, E.M.*
AU  - Moda, G.*
AU  - Rodriguez-Mañas, L.*
AU  - Vontetsianos, T.*
AU  - Abreu, C.*
AU  - Alonso, J.*
AU  - Alonso-Bouzon, C.*
AU  - Ankri, J.C.*
AU  - Arredondo, M.T.*
AU  - Avolio, F.*
AU  - Bedbrook, A.*
AU  - Białoszewski, A.Z.*
AU  - Blain, H.*
AU  - Bourret, R.*
AU  - Cabrera-Umpierrez, M.F.*
AU  - Catala, A.*
AU  - O’Caoimh, R.*
AU  - Cesari, M.*
AU  - Chavannes, N.H.*
AU  - Correia-Da-Sousa, J.*
AU  - Dedeu, T.*
AU  - Ferrando, M.*
AU  - Ferri, M.*
AU  - Fokkens, W.J.*
AU  - Garcia-Lizana, F.*
AU  - Guérin, O.*
AU  - Hellings, P.W.*
AU  - Haahtela, T.*
AU  - Illario, M.*
AU  - Inzerilli, M.C.*
AU  - Lodrup Carlsen, K.C.*
AU  - Kardas, P.*
AU  - Keil, T.*
AU  - Maggio, M.*
AU  - Mendez-Zorrilla, A.*
AU  - Menditto, E.*
AU  - Schulz, H.
AU  - Michel, J.P.*
AU  - Murray, R.*
AU  - Noguès, M.*
AU  - O’Byrne-Maguire, I.*
AU  - Pappa, D.*
AU  - Parent, A.S.*
AU  - Pastorino, M.*
AU  - Robalo-Cordeiro, C.*
AU  - Samolinski, B.*
AU  - Siciliano, P.*
AU  - Teixeira, A.M.*
AU  - Tsartara, S.I.*
AU  - Valiulis, A.*
AU  - Kaitov, M.R.*
C1  - 49808
C2  - 40961
SP  - 92-104
TI  - Building bridges for innovation in ageing: Synergies between Action Groups of the EIP on AHA.
JO  - J. Nutr. Health Aging
VL  - 21
IS  - 1
PY  - 2017
SN  - 1279-7707
ER  - 

TY  - JOUR
AB  - The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above.
AU  - Bousquet, J.*
AU  - Bewick, M.*
AU  - Cano, A.*
AU  - Eklund, P.*
AU  - Fico, G.*
AU  - Goswami, N.*
AU  - Guldemond, N.A.*
AU  - Henderson, D.W.*
AU  - Hinkema, M.J.*
AU  - Liotta, G.*
AU  - Mair, A.*
AU  - Molloy, W.*
AU  - Monaco, A.P.*
AU  - Monsonis-Paya, I.*
AU  - Nizinska, A.*
AU  - Papadopoulos, H.*
AU  - Pavlickova, A.*
AU  - Pecorelli, S.*
AU  - Prados-Torres, A.*
AU  - Roller-Wirnsberger, R.E.*
AU  - Somekh, D.*
AU  - Vera-Muñoz, C.*
AU  - Visser, F.*
AU  - Farrell, J.*
AU  - Malva, J.*
AU  - Andersen Ranberg, K.*
AU  - Camuzat, T.*
AU  - Carriazo, A.M.*
AU  - Crooks, G.*
AU  - Gutter, Z.*
AU  - Iaccarino, G.*
AU  - de Keenoy, E.M.*
AU  - Moda, G.*
AU  - Rodriguez-Mañas, L.*
AU  - Vontetsianos, T.*
AU  - Abreu, C.*
AU  - Alonso, J.*
AU  - Alonso-Bouzon, C.*
AU  - Ankri, J.C.*
AU  - Arredondo, M.T.*
AU  - Avolio, F.*
AU  - Bedbrook, A.*
AU  - Białoszewski, A.Z.*
AU  - Blain, H.*
AU  - Bourret, R.*
AU  - Cabrera-Umpierrez, M.F.*
AU  - Catala, A.*
AU  - O’Caoimh, R.*
AU  - Cesari, M.*
AU  - Chavannes, N.H.*
AU  - Correia-Da-Sousa, J.*
AU  - Dedeu, T.*
AU  - Ferrando, M.*
AU  - Ferri, M.*
AU  - Fokkens, W.J.*
AU  - Garcia-Lizana, F.*
AU  - Guérin, O.*
AU  - Hellings, P.W.*
AU  - Haahtela, T.*
AU  - Illario, M.*
AU  - Inzerilli, M.C.*
AU  - Lodrup Carlsen, K.C.*
AU  - Kardas, P.*
AU  - Keil, T.*
AU  - Maggio, M.*
AU  - Mendez-Zorrilla, A.*
AU  - Menditto, E.*
AU  - Schulz, H.
AU  - Michel, J.P.*
AU  - Murray, R.*
AU  - Noguès, M.*
AU  - O’Byrne-Maguire, I.*
AU  - Pappa, D.*
AU  - Parent, A.S.*
AU  - Pastorino, M.*
AU  - Robalo-Cordeiro, C.*
AU  - Samolinski, B.*
AU  - Siciliano, P.*
AU  - Teixeira, A.M.*
AU  - Tsartara, S.I.*
AU  - Valiulis, A.*
C1  - 50060
C2  - 42322
SP  - 1
TI  - Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA.
JO  - J. Nutr. Health Aging
PY  - 2016
SN  - 1279-7707
ER  - 

TY  - JOUR
AB  - Health is a multi-dimensional concept, capturing how people feel and function. The broad concept of Active and Healthy Ageing was proposed by the World Health Organisation (WHO) as the process of optimizing opportunities for health to enhance quality of life as people age. It applies to both individuals and population groups. A universal Active and Healthy Ageing definition is not available and it may differ depending on the purpose of the definition and/or the questions raised. While the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has had a major impact, a definition of Active and Healthy Ageing is urgently needed. A meeting was organised in Montpellier, France, October 20-21, 2014 as the annual conference of the EIP on AHA Reference Site MACVIA-LR (Contre les Maladies Chroniques pour un Vieillissement Actif en Languedoc Roussillon) to propose an operational definition of Active and Healthy Ageing including tools that may be used for this. The current paper describes the rationale and the process by which the aims of the meeting will be reached.
AU  - Bousquet, J.*
AU  - Kuh, D.*
AU  - Bewick, M.*
AU  - Standberg, T.*
AU  - Farrell, J.*
AU  - Pengelly, R.*
AU  - Joël, M.E.*
AU  - Rodriguez Mañas, L.*
AU  - Mercier, J.*
AU  - Bringer, J.*
AU  - Camuzat, T.*
AU  - Bourret, R.*
AU  - Bedbrook, A.*
AU  - Kowalski, M.L.*
AU  - Samolinski, B.*
AU  - Bonini, S.*
AU  - Brayne, C.*
AU  - Michel, J.P.*
AU  - Venne, J.*
AU  - Viriot-Durandal, P.*
AU  - Alonso, J.*
AU  - Avignon, A.*
AU  - Ben-Shlomo, Y.*
AU  - Bousquet, P.J.*
AU  - Combe, B.G.*
AU  - Cooper, R.*
AU  - Hardy, R.*
AU  - Iaccarino, G.*
AU  - Keil, T.*
AU  - Kesse-Guyot, E.*
AU  - Momas, I.*
AU  - Ritchie, K.*
AU  - Robine, J.M.*
AU  - Thijs, C.*
AU  - Tischer, C.G.
AU  - Vellas, B.*
AU  - Zaidi, A.*
AU  - Alonso, F.*
AU  - Andersen Ranberg, K.*
AU  - Andreeva, V.*
AU  - Ankri, J.C.*
AU  - Arnavielhe, S.*
AU  - Arshad, H.*
AU  - Augé, P.*
AU  - Berr, C.*
AU  - Bertone, P.*
AU  - Blain, H.*
AU  - Blasimme, A.*
AU  - Buijs, G.J.*
AU  - Caimmi, D.*
AU  - Carriazo, A.*
AU  - Cesario, A.*
AU  - Coletta, J.*
AU  - Maier, D.*
AU  - Malva, J.*
AU  - Matignon, P.*
AU  - Melén, E.*
AU  - Moda, G.*
AU  - Nizinkska, A.*
AU  - Noguès, M.*
AU  - Porta, D.*
AU  - Postma, D.*
AU  - Puisieux, F.*
AU  - Richards, M.*
AU  - Robalo-Cordeiro, C.*
AU  - Romano, V.*
AU  - Schulz, H.
AU  - Scott, A.*
AU  - Slagter, S.N.*
AU  - Smit, H.A.*
AU  - Somekh, D.*
AU  - Stafford, M.*
AU  - Todo-Bom, A.*
AU  - Mercier, G.*
AU  - O'Neill, M.*
AU  - Pélissier, J.Y.*
AU  - Poethig, D.*
AU  - Roubille, F.*
AU  - Senesse, P.*
AU  - Suanzes, J.*
AU  - Touchon, J.*
AU  - Traver Salcedo, V.*
AU  - van Beurden, M.*
AU  - Varraso, R.*
AU  - Vergara, I.*
AU  - Villalba-Mora, E.*
AU  - Wilson, N.*
AU  - Wouters, E.*
AU  - Zins, M.*
C1  - 46892
C2  - 39010
SP  - 955-960
TI  - Operational definition of Active and Healthy Ageing (AHA): A conceptual framework.
JO  - J. Nutr. Health Aging
VL  - 19
IS  - 9
PY  - 2015
SN  - 1279-7707
ER  - 

TY  - JOUR
AB  - Conclusion: Subjects with 25(OH)D serum levels ≥15 ng/ml were less frequently prefrail or frail. Objectives: Older adults often suffer from vitamin D deficiency and from the frailty syndrome charac-terized by different physical limitations, complicating independent everyday life. Previous studies have suggested a relationship between vitamin D status and the frailty syndrome, but results have been partly inconsistent, particularly regarding the shape of the association. Therefore, our aim was to further assess the association of 25-hydroxyvitamin D (25(OH)D) serum levels and frailty in older participants. Design: Cross-sectional population-based study. Participants: The study population included 478 men and 462 women of the KORA (COoperative health research in the Region of Augsburg)-Age study born before 1944 examined in 2009. Measurements: Classification of participants into different frailty states was performed according to the following criteria: weight loss, exhaustion, physical inactivity, slowness, and weakness. Participants who met 1−2 or ≥3 of the 5 criteria were classified as prefrail or frail, respectively. Total 25(OH)D was measured in non-fasting serum samples with an enhanced chemiluminescence immunoassay. Sequential logistic regression models adjusted for age, sex, season, lifestyle factors, diseases and biomarkers including parathyroid hormone (PTH) were calculated. Results: High levels of 25(OH)D were inversely associated with being prefrail (N=351) or frail (N=38) in the model adjusted for age, sex, season and lifestyle factors. Compared to levels <15 ng/ml, odds ratios (ORs) (95% confidence intervals (CIs) were 0.52 (0.34–0.78) for levels of 15−<20 ng/ml, 0.55 (0.37–0.81) for levels of 20−<30 ng/ml and 0.32 (0.21–0.51) for levels ≥30 ng/ml. Additional adjustment for potential mediators including PTH only slightly attenuated these associations. For single frailty-components, significantly decreased ORs were found for exhaustion, physical inactivity and slowness comparing 25(OH)D levels ≥30 ng/ml with levels <15 ng/ml.
AU  - Pabst, G.
AU  - Zimmermann, A.-K.
AU  - Huth, C.
AU  - Koenig, W.*
AU  - Ludwig, T.
AU  - Zierer, A.
AU  - Peters, A.
AU  - Thorand, B.
C1  - 42873
C2  - 35647
CY  - Paris
SP  - 258-264
TI  - Association of low 25-hydroxyvitamin D levels with the frailty syndrome in an aged population: Results from the KORA-Age Augsburg study.
JO  - J. Nutr. Health Aging
VL  - 19
IS  - 3
PB  - Springer France
PY  - 2015
SN  - 1279-7707
ER  - 

TY  - JOUR
AB  - Current population-based surveys in Europe on the prevalence of dietary supplement (DS) use in older individuals are scarce. The aim of the present study was to investigate patterns, prevalence and determinants of non-herbal DS use in aged subjects. Furthermore, the intake amounts of vitamins and minerals from supplements were assessed. Cross-sectional. Data on supplement use were available from an age- and sex-stratified random sample of the German population-based KORA (Cooperative Health Research in the Region of Augsburg)-Age study. 1,079 persons who were born in or before the year 1943. Use of dietary supplements and medications during the last seven days was recorded in a face-to-face interview in 2009. Participants were asked to bring all packages of ingested preparations to the study center. Not only vitamin/mineral supplements, but also non-vitamin non-mineral non-herbal supplements and drugs containing vitamins and minerals were coded as DS. The age-standardized prevalence of DS intake was 54.3% in women and 33.8% in men, respectively. The most commonly supplemented mineral and vitamin, respectively, was magnesium (31.9%) and vitamin D (21.5%) in women and magnesium (18.0%) and vitamin E (12.0%) in men. The highest intakes, compared to the German Dietary Reference Intakes, were reported for biotin, vitamin B-6 and B-1. Excessive intakes (equal or above the European Tolerable Upper Intake Levels (UL)) were observed especially for magnesium and vitamin E. 20.2% of the women and 32.5% of the men who took magnesium supplements regularly exceeded the UL for magnesium. In case of vitamin E this was true for 8.0% of the women and 13.6% of the men. Determinants of DS use were sex, education, smoking, physical activity, neurological diseases, and stroke. A high proportion of the general population aged 65 years and older in Southern Germany uses DS, especially supplements containing vitamins/minerals. The supplementation of vitamin D can be regarded as favorable in this age group, whereas the excessive intakes of vitamin E might be a cause of concern.
AU  - Schwab, S.
AU  - Heier, M.
AU  - Schneider, A.E.
AU  - Fischer, B.*
AU  - Huth, C.
AU  - Peters, A.
AU  - Thorand, B.
C1  - 28597
C2  - 33471
CY  - Paris
SP  - 510-519
TI  - The use of dietary supplements among older persons in Southern Germany - results from the KORA-age study.
JO  - J. Nutr. Health Aging
VL  - 18
IS  - 5
PB  - Springer France
PY  - 2014
SN  - 1279-7707
ER  -