TY - JOUR AB - Early administration of reperfusion therapy in acute ST-elevation myocardial infarctions (STEMI) is crucial to reduce mortality. Although female sex and old age are key factors contributing to an inadequate long prehospital delay time, little is known whether women ≥65 years are a particular risk population. Hence, we studied the interaction of sex and age (<65 years or ≥65 years) and the contribution of chest pain to delay time during STEMI. Bedside interview data were collected in 619 STEMI patients from the Munich Examination of Delay in Patients Experiencing Acute Myocardial Infarction (MEDEA) study. Sex and age group stratification disclosed an excess delay risk for women ≥65 years, accounting for a 2.39 (95% confidence interval (CI) 1.39 to 4.10)-fold higher odds to delay longer than 2 hours compared with all other patient groups including younger women (p ≤0.002). Median delay time was 266 minutes in women ≥65 years and 148 minutes in younger women (p <0.001). Chest pain during STEMI had the lowest frequency both in women (81%) and men ≥65 years (83%) and the highest frequency (95%) in younger women. Experiencing non-chest pain was 2.32-fold (95% CI, 1.20 to 4.46, p <0.05) higher in women ≥65 years than in all other patients. Mediation analysis disclosed that the effect accounted for only 9% of the variance. Age specific educational strategies targeting women ≥65 years at risk are urgently needed. To tailor adequate strategies, more research is required to understand age- and sex driven barriers to timely identification of ischemic symptoms. AU - Ladwig, K.-H. AU - Fang, X. AU - Wolf, K. AU - Hoschar, S. AU - Albarqouni, L. AU - Ronel, J.* AU - Meinertz, T.* AU - Spieler, D.* AU - Laugwitz, K.L.* AU - Schunkert, H.* C1 - 52313 C2 - 43907 CY - Bridgewater SP - 2128-2134 TI - Comparison of delay times between symptom onset of an acute ST-elevation myocardial infarction and hospital arrival in men and women <65 years versus ≥65 years of age.: Findings from the Multicenter Munich Examination of Delay in Patients Experiencing Acute Myocardial Infarction (MEDEA) Study. JO - Am. J. Cardiol. VL - 120 IS - 12 PB - Excerpta Medica Inc-elsevier Science Inc PY - 2017 SN - 0002-9149 ER - TY - JOUR AB - Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have shown to decrease mortality and cardiovascular morbidity especially in high-risk patients after acute myocardial infarction (AMI). Aim of this study was to assess the association between ACEI or ARB treatment (ACEI/ARB) at hospital discharge and long-term survival after AMI in real-life patient care. From a German population-based AMI registry, 3,544 patients (75.4% men), aged 28 to 74 years, hospitalized with an incident AMI between 2000 and 2008, surviving at least 24 hours and treated with β blockers and antiplatelet agents at discharge were included in this study. All data were collected by standardized interviews and chart review. End point of this study was all-cause mortality at 3 follow-up periods: 1, 3, and 5 years after AMI. Mortality was assessed for all registered patients in 2010. Survival analyses and multivariable Cox regression analyses were conducted. Of the 3,544 patients, 83.7% received ACEI/ARB and 90.1% were treated with statins at hospital discharge. During a median follow-up period of 5.0 years (interquartile range 1.0 years), 9.3% patients died. In the multivariable Cox models adjusting for a number of covariates, use of ACEI/ARB showed a significantly inverse relation with 1-, 3-, and 5-year mortality (e.g., 5-year mortality: hazard ratio 0.74, 95% confidence interval 0.59 to 0.94, p = 0.015), and the hazard ratios for mortality did not differ significantly between the 3 examined follow-up periods. In conclusion, use of ACEI/ARB at hospital discharge is independently associated with long-term survival benefit in patients with incident AMI already treated with other guideline-recommended cardiovascular drugs. AU - Amann, U. AU - Kirchberger, I. AU - Heier, M. AU - Zirngibl, A. AU - von Scheidt, W.* AU - Kuch, B.* AU - Peters, A. AU - Meisinger, C. C1 - 31620 C2 - 34626 CY - Bridgewater SP - 329-335 TI - Effect of renin-angiotensin system inhibitors on long-term survival in patients treated with beta blockers and antiplatelet agents after acute mocardial infarction (from the MONICA/KORA Myocardial Infarction Registry). JO - Am. J. Cardiol. VL - 114 IS - 3 PB - Excerpta Medica Inc-elsevier Science Inc PY - 2014 SN - 0002-9149 ER - TY - JOUR AB - Many studies have examined gender-related differences in symptoms of acute myocardial infarction (AMI). However, findings have been inconsistent, largely because of different study populations and different methods of symptom assessment and data analysis. This study was based on 568 women and 1,710 men 25 to 74 years old hospitalized with a first-ever AMI from January 2001 through December 2006 recruited from a population-based AMI registry. Occurrence of 13 AMI symptoms was recorded using standardized patient interview. After controlling for age, migration status, body mass index, smoking, some co-morbidities including diabetes, and type and location of AMI through logistic regression modeling, women were significantly more likely to complain of pain in the left shoulder/arm/hand (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.10 to 1.69), pain in the throat/jaw (OR 1.78, 95% CI 1.43 to 2.21), pain in the upper abdomen (OR 1.39, 95% CI 1.02 to 1.91), pain between the shoulder blades (OR 2.22, 95% CI 1.78 to 2.77), vomiting (OR 2.23, 95% CI 1.67 to 2.97), nausea (OR 1.94, 95% CI 1.56 to 2.39), dyspnea (OR 1.45, 95% CI 1.17 to 1.78), fear of death (OR 2.17, 95% CI 1.73 to 2.72), and dizziness (OR 1.49, 95% CI 1.16 to 1.91) than men. Furthermore, women were more likely to report >4 symptoms (OR 2.14, 95% CI 1.72 to 2.66). No significant gender differences were found in chest pain, feelings of pressure or tightness, diaphoresis, pain in the right shoulder/arm/hand, and syncope. In conclusion, women and men did not differ regarding the chief AMI symptoms of chest pain or feelings of tightness or pressure and diaphoresis. However, women were more likely to have additional symptoms. AU - Kirchberger, I. AU - Heier, M. AU - Kuch, B.* AU - Wende, R.* AU - Meisinger, C. C1 - 6500 C2 - 28818 CY - New York, NY SP - 1585-1589 TI - Sex differences in patient-reported symptoms associated with myocardial infarction (from the population-based MONICA/KORA Myocardial Infarction Registry). JO - Am. J. Cardiol. VL - 107 IS - 11 PB - Excerpta Medica PY - 2011 SN - 0002-9149 ER - TY - JOUR AB - The high incidence of sudden cardiac death in heart failure (HF) reflects electrophysiologic changes in response to myocardial failure. We previously showed that short-term variability of QT intervals (STV(QT)) identifies latent repolarization disorders in patients with drug-induced or congenital long QT syndrome. This study sought to determine (1) if STV(QT) is increased in patients with dilated cardiomyopathy (DC) and moderate congestive HF and (2) if increased STV(QT) is associated with ventricular arrhythmia in patients with HF. Sixty patients (53 +/- 12 years of age, 14 women) with DC and moderate HF (New York Heart Association classes II to III) were compared to matched controls. Twenty patients had implantable cardiac defibrillators secondary to a history of ventricular tachycardia (VT). Two cardiologists blinded to diagnosis manually measured QT intervals. Beat-to-beat variability of repolarization was determined from Poincaré plots of 30 consecutive QT intervals as was STV(QT). QTc intervals were comparable in patients and controls (419 +/- 36 vs 415 +/- 32 ms, respectively, p >0.05), whereas STV(QT) was significantly higher in patients with HF (7.8 +/- 3 vs 4.1 +/- 2 ms, respectively, p <0.05). STV(QT) was more increased in patients with a history of VT compared to those without VT (10.1 +/- 2 vs 6.6 +/- 2 ms, respectively, p <0.05). Increased STV(QT) and decreased ejection fraction were associated with a history of VT; however, STV(QT) was the strongest indicator. In conclusion, the present study demonstrates for the first time that STV(QT) is increased in patients with DC with HF. Patients with DC and HF and implantable cardiac defibrillators for secondary prevention had the highest STV(QT). Thus, increased STV(QT) in the context of moderate HF may reflect a latent repolarization disorder and increased susceptibility to sudden death in patients with DC, which is not identified by a prolonged QT interval. AU - Hinterseer, M.* AU - Beckmann, B.-M.* AU - Thomsen, M.B.* AU - Pfeufer, A.* AU - Ulbrich, M.* AU - Sinner, M.F.* AU - Perz, S. AU - Wichmann, H.-E. AU - Lengyel, C.* AU - Schimpf, R.* AU - Maier, S.K.G.* AU - Andras, V.* AU - Vos, M.A.* AU - Steinbeck, G.* AU - Kääb, S.* C1 - 2894 C2 - 27404 SP - 216-220 TI - Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. JO - Am. J. Cardiol. VL - 106 IS - 2 PB - Elsevier PY - 2010 SN - 0002-9149 ER - TY - JOUR AB - The aim of this study was to investigate gender-specific short- and long-term mortalities after a first acute myocardial infarction (AMI) in patients with and without diabetes mellitus (DM). The study was based on 505 men and 196 women with DM and 1,327 men and 415 women without DM consecutively hospitalized with a first-ever AMI from January 1998 to December 2003 recruited from a population-based MI registry. Patients were followed until December 31, 2005 (median follow-up time 4.3 years). In men and women, no significantly independent association between DM and short-term mortality was observed. After multivariable adjustment odds ratios (95% confidence intervals [CIs]) for 28-day case fatality were 1.45 (95% CI 0.90 to 2.34) in men with DM compared to men without DM and 1.44 (95% CI 0.66 to 3.15) in women with DM compared to women without DM. Conversely, in 28-day AMI survivors DM was significantly associated with long-term mortality in age-adjusted analyses, in which men with DM had a hazard ratio (HR) of 1.57 (95% CI 1.18 to 2.10) for all-cause mortality compared to non-DM men; the corresponding HR in women with DM was 2.91 (95% CI 1.82 to 4.65). After multivariable adjustment the strong association in women with DM remained significant (HR 2.56, 95% CI 1.53 to 4.27); however, in men with DM it became borderline significant (HR 1.36, 95% CI 1.00 to 1.85). In conclusion, short-term mortality was not significantly increased in men and women with DM after a first-ever AMI, although estimates were relatively high, indicating a possible relation. However, long-term mortality was higher in patients with AMI and DM, particularly in women. AU - Meisinger, C. AU - Heier, M. AU - von Scheidt, W.* AU - Kirchberger, I. AU - Hörmann, A. AU - Kuch, B.* C1 - 3171 C2 - 28379 SP - 1680-1684 TI - Gender-specific short and long-term mortality in diabetic versus nondiabetic patients with incident acute myocardial infarction in the reperfusion era (the MONICA/KORA Myocardial Infarction Registry). JO - Am. J. Cardiol. VL - 106 IS - 12 PB - Elsevier PY - 2010 SN - 0002-9149 ER - TY - JOUR AB - The aim of this study was to investigate the association between increased admission glucose in nondiabetic (ND) patients and in patients with type 2 diabetes mellitus (T2DM) with first acute myocardial infarctions (AMIs) and 28-day as well as 1- and 3-year case fatality. The Monitoring Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) myocardial infarction registry database in Augsburg, Germany, was used, and 1,631 patients without and 659 patients with T2DM (aged 25 to 74 years) who were admitted from 1998 to 2003 with first AMIs were included. Mortality follow-up was carried out in 2005. ND patients with AMIs with admission glucose >152 mg/dl (top quartile) compared with those in the bottom quartile had an odds ratio of 2.82 (95% confidence interval [CI] 1.30 to 6.12) for death within 28 days after multivariate adjustment; correspondingly, patients with T2DM with admission glucose >278 mg/dl (top quartile) compared with those in the bottom quartile (<152 mg/dl) showed a nonsignificantly increased odds ratio of 1.45 (95% CI 0.64 to 3.31). After the exclusion of patients who died within 28 days, a nonsignificantly increased relative risk (RR) was seen between admission blood glucose and 1-year mortality in ND subjects (RR 2.71, 95% CI 0.90 to 8.15), whereas no increased RR was found in subjects with diabetes (RR 0.99, 95% CI 0.34 to 2.82). After 3 years, there was no increased risk for death in patients with high admission blood glucose levels, neither for ND patients nor for those with T2DM. In conclusion, elevated admission blood glucose is associated with increased short-term mortality risk in patients with AMIs, particularly in ND subjects. These patients constitute a high-risk group needing aggressive, comprehensive polypharmacotherapy. AU - Beck, J.A. AU - Meisinger, C. AU - Heier, M. AU - Kuch, B.* AU - Hörmann, A. AU - Greschik, C. AU - Koenig, W.* C1 - 2236 C2 - 26665 CY - United States SP - 1607-1612 TI - Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry). JO - Am. J. Cardiol. VL - 104 IS - 12 PB - Elsevier PY - 2009 SN - 0002-9149 ER - TY - JOUR AB - The present study investigated the association between C-reactive protein (CRP) on admission independently and in combination with troponin and short-term prognosis in an unselected sample of patients with acute myocardial infarction (AMI) from the community. The study population consisted of 1,646 patients aged 25 to 74 years who were consecutively hospitalized with AMI within 12 hours after symptom onset. They were divided into the 2 groups of CRP positive (n = 919) or CRP negative (n = 727) with respect to admission CRP (cutoff <= 0.3 mg/dl). CRP-positive patients had significantly more in-hospital complications and a higher 28-day case-fatality rate (9.6% vs 3.4%; p <0.0001). Troponin at admission (n = 1,419) also correlated with 28-day case-fatality rate (troponin-negative 3.4% vs troponin-positive patients 8.0%; p <0.002). Multivariable analysis showed that both troponin positivity and CRP positivity were associated with a 2-fold (adjusted odds ratio 1.99, 95% confidence interval 1.15 to 3.44; adjusted odds ratio 2.05, 95% confidence interval 1.09 to 3.84, respectively) increased risk of dying within 28 days after the acute event for all patients with AMI. Stratifying by AMI type showed that in patients with ST-elevation myocardial infarction (STEMI), troponin positivity, but not CRP positivity, independently predicted 28-day case fatality. In patients with non-STEMI, CRP positivity, but not troponin positivity, predicted outcome. In conclusion, admission CRP was a powerful parameter for risk stratification of patients with AMI. Stratification by AMI type and troponin showed that CRP was a better short-term risk predictor for patients with non-STEMI, and troponin was, for patients with STEMI. AU - Kuch, B.* AU - von Scheidt, W.* AU - Kling, B.* AU - Heier, M. AU - Hoermann, A. AU - Meisinger, C. C1 - 1673 C2 - 25990 SP - 1125-1130 TI - Differential Impact of Admission C-Reactive Protein Levels on 28-Day Mortality Risk in Patients With ST-Elevation Versus Non-ST-Elevation Myocardial Infarction (from the Monitoring Trends and Determinants on Cardiovascular Diseases [MONICA]/Cooperative Health research in the Region of Augsburg [KORA] Augsburg Myocardial Infarction Registry). JO - Am. J. Cardiol. VL - 102 IS - 9 PY - 2008 SN - 0002-9149 ER - TY - JOUR AB - Acute myocardial infarctions (AMIs) are categorized according to presenting electrocardiography into ST-elevation (STE), non-STE, and bundle branch block AMIs. Data on the characteristics and risks of these categories originate mainly from voluntary registries or clinical trials and may be hampered by selection and information bias. This study evaluated these different categories, with the additional differentiation of non-STE AMIs into ST-depression (STD) AMIs and those with nonspecific electrocardiographic signs (no-ST) in an unselected cohort. From 1985 to 2004, all consecutive patients aged 25 to 74 years who were hospitalized with AMI at the study region's major clinic were registered prospectively. A total of 6,748 patients were identified, of whom 45.8% had STE, 14.0% STD, 32.4% no-ST, and 7.8% bundle branch block AMIs, respectively. There were substantial differences in medical history, presentation, and therapy among the AMI types. Even after adjusting for the latter factors, the odds ratios of 28-day case fatality compared with no-ST were 1.26 (95% confidence interval 1.01 to 1.59) for STE, 1.84 (95% confidence interval 1.39 to 2.44) for STD, and 3.18 (95% confidence interval 2.37 to 4.27) for bundle branch block. In conclusion, after considering in-hospital therapy, the difference between STE and no-ST was nonsignificant, whereas the case-fatality difference between no-ST and STD persisted, suggesting some other unknown underlying factors associated with STD. AU - Kuch, B.* AU - von Scheidt, W. AU - Kling, B.* AU - Heier, M. AU - Hörmann, A. AU - Meisinger, C. C1 - 3532 C2 - 24922 SP - 1056-1060 TI - Characteristics and outcome of patients with acute myocardial infarction according to presenting electrocardiogram (from the MONICA/KORA Augsburg Myocardial Infarction--Registry). JO - Am. J. Cardiol. VL - 100 IS - 7 PB - Elsevier PY - 2007 SN - 0002-9149 ER -