TY  - JOUR
AB  - Fetal sex has been associated with different development trajectories that cause structural and functional differences between the sexes throughout gestation. Fetal magnetocardiography (fMCG) recordings from 123 participants (64 females and 59 males; one recording/participant) from a database consisting of low-risk pregnant women were analyzed to explore and compare fetal development trajectories of both sexes. The gestational age of the recordings ranged from 28 to 38 weeks. Linear metrics in both the time and frequency domains were applied to study fetal heart rate variability (fHRV) measures that reveal the dynamics of short- and long-term variability. Rates of linear change with GA in these metrics were analyzed using general linear model regressions with assessments for significantly different variances and GA regression slopes between the sexes. The fetal sexes were well balanced for GA and sleep state. None of the fHRV measures analyzed exhibited significant variance heterogeneity between the sexes, and none of them exhibited a significant sex-by-GA interaction. The absence of a statistically significant sex-by-GA interaction on all parameters resulted in none of the regression slope estimates being significantly different between the sexes. With high-precision fMCG recordings, we were able to explore the variation in fHRV parameters as it relates to fetal sex. The fMCG-based fHRV parameters did not show any significant difference in rates of change with gestational age between sexes. This study provides a framework for understanding normal development of the fetal autonomic nervous system, especially in the context of fetal sex.
AU  - Mercado, L.*
AU  - Escalona-Vargas, D.*
AU  - Siegel, E.R.*
AU  - Preissl, H.
AU  - Bolin, E.H.*
AU  - Eswaran, H.*
C1  - 68697
C2  - 54906
CY  - Tiergartenstrasse 17, D-69121 Heidelberg, Germany
TI  - Exploring the influence of fetal sex on heart rate dynamics using fetal magnetocardiographic recordings.
JO  - Reprod. Sci.
PB  - Springer Heidelberg
PY  - 2023
SN  - 1933-7191
ER  - 

TY  - JOUR
AU  - Sharma, R.
AU  - Zelgert, C.*
AU  - Zimmermann, P.*
AU  - Berg, G.*
AU  - Fabre, B.*
AU  - Wilson, R.
AU  - Kriebel, J.
AU  - Waldenberger, M.
AU  - Frasch, M.G.*
AU  - Lobmaier, S.M.*
AU  - Antonelli, M.C.*
C1  - 58992
C2  - 48470
CY  - Tiergartenstrasse 17, D-69121 Heidelberg, Germany
SP  - 324A-324A
TI  - Non-invasive biophysical and epigenetic biomarkers of prenatal stress in a human cohort: FELICITy study.
JO  - Reprod. Sci.
VL  - 27
IS  - SUPPL 1
PB  - Springer Heidelberg
PY  - 2020
SN  - 1933-7191
ER  - 

TY  - JOUR
AU  - Linder, K.
AU  - Schleger, F.
AU  - Ketterer, C.
AU  - Fritsche, L.
AU  - Kiefer-Schmidt, I.*
AU  - Hennige, A.M.*
AU  - Häring, H.-U.
AU  - Preissl, H.
AU  - Fritsche, A.
C1  - 31520
C2  - 34529
CY  - Thousand Oaks
SP  - 373A
TI  - Fetal brain activity and maternal metabolism.
JO  - Reprod. Sci.
VL  - 21
IS  - 3
PB  - Sage Publications Inc
PY  - 2014
SN  - 1933-7191
ER  -