TY  - JOUR
AB  - Research question: Do women with polycystic ovary syndrome (PCOS) have higher testosterone levels during pregnancy and what role does high testosterone play in the development of obstetric complications? Design: Retrospective cohort study from Uppsala University Hospital, Sweden. The study population consisted of women with PCOS (n = 159) and a comparison group of women without PCOS matched for body mass index (n = 320). Plasma testosterone levels were measured in the early second trimester by liquid chromatography with tandem mass spectrometry, and women with PCOS were grouped into tertiles according to their testosterone levels. Possible associations with obstetric complications, maternal metabolic factors and offspring birth weight were explored by multivariable logistic and linear regression models. Results: Compared with women who do not have PCOS, women with PCOS had higher total testosterone (median 1.94, interquartile range [IQR] 1.21–2.64 versus 1.41, IQR 0.89–1.97; P < 0.001), and free androgen index (median 0.25, IQR 0.15–0.36 versus 0.18, IQR 0.11–0.28; P < 0.001). Women with PCOS who had the highest levels of testosterone had increased risk for preeclampsia, even when adjusted for age, parity, country of birth and smoking (adjusted OR 6.16, 95% CI 1.82 to 20.91). No association was found between high testosterone in women with PCOS and other obstetric complications. Conclusions: Women with PCOS have higher levels of total testosterone and free androgen index during pregnancy than women without PCOS matched for body mass index. Preliminary evidence shows that women with PCOS and the highest maternal testosterone levels in early second trimester had the highest risk of developing preeclampsia. This finding, however, is driven by a limited number of cases and should be interpreted with caution.
AU  - Valdimarsdottir, R.*
AU  - Wikström, A.K.*
AU  - Kallak, T.K.*
AU  - Elenis, E.*
AU  - Axelsson, O.*
AU  - Preissl, H.
AU  - Ubhayasekera, S.J.K.A.*
AU  - Bergquist, J.*
AU  - Poromaa, I.S.*
C1  - 60364
C2  - 49189
CY  - The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
SP  - 217-225
TI  - Pregnancy outcome in women with polycystic ovary syndrome in relation to second-trimester testosterone levels.
JO  - Reprod. Biomed. Online
VL  - 42
IS  - 1
PB  - Elsevier Sci Ltd
PY  - 2021
SN  - 1472-6483
ER  - 

TY  - JOUR
AB  - This observational study assessed whether women descending from consanguineous unions have reduced ovarian reserve compared with daughters of non-consanguine couples. Two hundred and ninety-one women (≤39 years) were treated in a tertiary care centre in Kuwait. Women underwent a complete anamnesis, including an evaluation of the possible presence of parental consanguinity, transvaginal ultrasound on day 2/3 of the cycle to obtain the antral follicle count (AFC), determination of serum concentrations of FSH, LH, oestradiol and in case of low ovarian reserve (AFC < 9) anti-Müllerian hormone (AMH). The median AFC of non-consanguineous daughters was 11, while daughters from consanguineous parents displayed a significantly lower median AFC (7; P < 0⋅0001). FSH was slightly higher in the consanguineous patients, while LH and oestradiol concentrations did not vary between groups. In total, 29.9% of consanguineous patients had an AFC ≥ 9, compared with 63.9% of non-consanguineous patients. Consanguineous patients did not exhibit an age-dependent AFC-decline and displayed reduced AFC and AMH concentrations. The multivariate analysis revealed female consanguinity, as well as surgical history in non-consanguineous women, as strong positive predictors of low ovarian reserve. Parental consanguinity is strongly associated with reduced ovarian reserve. Future studies should evaluate a possible association between parental consanguinity and infertility.
AU  - Seher, T*
AU  - Thiering, E.
AU  - al Azemi, M.*
AU  - Heinrich, J.
AU  - Schmidt-Weber, C.B.
AU  - Kivlahan, C.*
AU  - Gutermuth, J.*
AU  - Fatemi, H.M.*
C1  - 46273
C2  - 37468
CY  - Oxford
SP  - 427-433
TI  - Is parental consanguinity associated with reduced ovarian reserve?
JO  - Reprod. Biomed. Online
VL  - 31
IS  - 3
PB  - Elsevier Sci Ltd
PY  - 2015
SN  - 1472-6483
ER  -