TY  - JOUR
AB  - Extended reality (XR), which encompasses virtual, augmented and mixed reality, is an emerging medical imaging display platform which enables intuitive and immersive interaction in a three-dimensional space. This technology holds the potential to enhance understanding of complex spatial relationships when planning and guiding cardiac procedures in congenital and structural heart disease moving beyond conventional 2D and 3D image displays. A systematic review of the literature demonstrates a rapid increase in publications describing adoption of this technology. At least 33 XR systems have been described, with many demonstrating proof of concept, but with no specific mention of regulatory approval including some prospective studies. Validation remains limited, and true clinical benefit difficult to measure. This review describes and critically appraises the range of XR technologies and its applications for procedural planning and guidance in structural heart disease while discussing the challenges that need to be overcome in future studies to achieve safe and effective clinical adoption.
AU  - Stephenson, N.*
AU  - Pushparajah, K.*
AU  - Wheeler, G.*
AU  - Deng, S.*
AU  - Schnabel, J.A.
AU  - Simpson, J.M.*
C1  - 67790
C2  - 54268
CY  - Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands
SP  - 1405-1419
TI  - Extended reality for procedural planning and guidance in structural heart disease - a review of the state-of-the-art.
JO  - Int. J. Cardiovasc. Imaging
VL  - 39
IS  - 7
PB  - Springer
PY  - 2023
SN  - 1569-5794
ER  - 

TY  - JOUR
AB  - Consistent protocols for the assessment of diastolic and systolic cardiac function to assure the comparability of existing data on preclinical models are missing. Calcineurin transgene (CN) mice are a preclinical model for hypertrophic and failing hearts. We aimed at evaluating left and right ventricular structural and functional remodeling in CN hearts with an optimized phenotyping protocol. We developed a protocol using techniques and indices comparable to those from human diagnostics for comprehensive in vivo cardiac screening using high-frequency echocardiography, Doppler, electrocardiography and cardiac magnetic resonance (CMR) techniques. We measured left and right ventricular dimensions and function, pulmonary and mitral flow pattern and the hearts electrophysiology non-invasively in <1 h per mouse. We found severe biventricular dilation and a drastic decline in performance in accordance with a condition of heart failure (HF), diastolic dysfunction and defects in electrical conduction in 8-week-old calcineurin transgenic mice. Echocardiography of the left ventricle was performed with and without anesthesia. In all cases absolute values on echocardiography compared with CMR were smaller for LV dimension and wall thickness, resulting in higher fractional shorting and ejection fraction. The study protocol described here opens opportunities to assess the added value of combined echocardiography, Doppler, CMR and ECG recording techniques for the diagnosis of biventricular cardiac pathologies i.e. of HF and to study symptom occurrence and disease progression non-invasively in high-throughput. Phenotyping CN hearts revealed new symptom occurrence and allowed insights into the diverse phenotype of hypertrophic failing hearts.
AU  - Moreth, K.
AU  - Afonso, L.C.
AU  - Fuchs, H.
AU  - Gailus-Durner, V.
AU  - Katus, H.A.*
AU  - Bekerdjian, R.*
AU  - Lehmann, L.*
AU  - Hrabě de Angelis, M.
C1  - 43201
C2  - 36127
CY  - Dordrecht
SP  - 669-679
TI  - High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
JO  - Int. J. Cardiovasc. Imaging
VL  - 31
IS  - 4
PB  - Springer
PY  - 2015
SN  - 1569-5794
ER  - 

TY  - JOUR
AU  - Moreth, K.
AU  - Afonso, L.C.
AU  - Fuchs, H.
AU  - Gailus-Durner, V.
AU  - Katus, H.A.*
AU  - Bekeredjian, R.*
AU  - Lehmann, L.*
AU  - Hrabě de Angelis, M.
C1  - 44554
C2  - 36941
CY  - Dordrecht
SP  - 1137
TI  - Erratum to: High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
JO  - Int. J. Cardiovasc. Imaging
VL  - 31
IS  - 6
PB  - Springer
PY  - 2015
SN  - 1569-5794
ER  -