TY  - JOUR
AB  - The reinforcing and motivational aspects of food are tied to the release of the dopamine in the mesolimbic system (ML). Free fatty acids from triglyceride (TG)-rich particles are released upon action of TG-lipases found at high levels in peripheral oxidative tissue (muscle, heart), but also in the ML. This suggests that local TG-hydrolysis in the ML might regulate food seeking and reward. Indeed, evidence now suggests that dietary TG directly target the ML to regulate amphetamine-induced locomotion and reward seeking behavior. Though the cellular mechanisms of TG action are unresolved, TG act in part through ML lipoprotein lipase, upstream of dopamine 2 receptor (D2R), and show desensitization in conditions of chronically elevated plasma TG as occur in obesity. TG sensing in the ML therefore represents a new mechanism by which chronic consumption of dietary fat might lead to adaptations in the ML and dysregulated feeding behaviors.
AU  - Berland, C.
AU  - Cansell, C.*
AU  - Hnasko, T.S.*
AU  - Magnan, C.*
AU  - Luquet, S.*
C1  - 48411
C2  - 41064
SP  - 126-135
TI  - Dietary triglycerides as signaling molecules that influence reward and motivation.
JO  - Curr. Opin. Behav. Sci.
VL  - 9
PY  - 2016
ER  -