TY  - JOUR
AB  - BACKGROUND: In magnetic resonance imaging (MRI), the comparability of gated and non-gated measurements of the left atrial (LA) area and function and their association with cardiovascular risk factors have not been firmly established. METHODS: 3-Tesla MRIs were performed on 400 subjects enrolled in the KORA (Cooperative Health Research in the Augsburg Region) MRI study. The LA maximum and minimum sizes were segmented in gated CINE four-chamber sequences (LAmax and LAmin) and non-gated T1 VIBE-Dixon (NGLA). The area-based LA function was defined as LAaf = (LAmax - LAmin)/LAmax. Inter-and intra-reader reliability tests were performed (n = 31). Linear regression analyses were conducted to link LA size and function with cardiovascular risk factors. RESULTS: Data from 378 subjects were included in the analysis (mean age: 56.3 years, 57.7 % male). The measurements were highly reproducible (all intraclass correlation coefficients ≥ 0.98). The average LAmax was 19.6 ± 4.5 cm2, LAmin 11.9 ± 3.5 cm2, NGLA 16.8 ± 4 cm2 and LAaf 40 ± 9%. In regression analysis, hypertension was significantly associated with larger gated LAmax (β = 1.30), LAmin (β = 1.07), and non-gated NGLA (β = 0.94, all p ≤ 0.037). Increasing age was inversely associated with LAaf (β = -1.93, p < 0.001). CONCLUSION: LA enlargement, as measured in gated and non-gated CMR is associated with hypertension, while the area-based LA function decreases with age.
AU  - Kulka, C.*
AU  - Lorbeer, R.*
AU  - Askani, E.*
AU  - Kellner, E.*
AU  - Reisert, M.*
AU  - von Krüchten, R.*
AU  - Rospleszcz, S.
AU  - Hasic, D.*
AU  - Peters, A.
AU  - Bamberg, F.*
AU  - Schlett, C.L.*
C1  - 66282
C2  - 53126
SP  - 2202-2217
TI  - Quantification of left atrial size and function in cardiac MR in correlation to non-gated MR and cardiovascular risk factors in subjects without cardiovascular disease: A population-based cohort study.
JO  - Tomography
VL  - 8
IS  - 5
PY  - 2022
SN  - 2379-1381
ER  - 

TY  - JOUR
AB  - Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFFhepatic). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. Results: VAT (β = −0.13, p = 0.03) and SAT (β = −0.26, p < 0.001), but not PDFFhepatic were inversely associated with FEV1, while VAT (β = −0.27, p < 0.001), SAT (β = −0.41, p < 0.001), and PDFFhepatic (β = −0.17, p = 0.002) were inversely associated with FVC. PDFFhepatic was directly associated with the Tiffeneau index (β = 2.46, p < 0.001). Conclusions: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFFhepatic revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.
AU  - von Krüchten, R.*
AU  - Rospleszcz, S.
AU  - Lorbeer, R.*
AU  - Hasic, D.*
AU  - Peters, A.
AU  - Bamberg, F.*
AU  - Schulz, H.
AU  - Karrasch, S.*
AU  - Schlett, C.L.*
C1  - 64573
C2  - 52001
SP  - 560-569
TI  - Whole-body MRI-derived adipose tissue characterization and relationship to pulmonary function impairment.
JO  - Tomography
VL  - 8
IS  - 2
PY  - 2022
SN  - 2379-1381
ER  - 

TY  - JOUR
AB  - Sparse recovery algorithms have shown great potential to accurately reconstruct images using limited-view optoacoustic (photoacoustic) tomography data sets, but these are computationally expensive. In this paper, we propose an improvement of the fast converging Split Augmented Lagrangian Shrinkage Algorithm method based on least square QR inversion for improving the reconstruction speed. We further show image fidelity improvement when using a coherence factor to weight the reconstruction result. Phantom and in vivo measurements show that the accelerated Split Augmented Lagrangian Shrinkage Algorithm method with coherence factor weighting offers images with reduced artifacts and provides faster convergence compared with existing sparse recovery algorithms.
AU  - He, H.
AU  - Prakash, J.
AU  - Bühler, A.
AU  - Ntziachristos, V.
C1  - 49117
C2  - 41588
SP  - 138-145
TI  - Optoacoustic tomography using accelerated sparse recovery and coherence factor weighting.
JO  - Tomography
VL  - 2
IS  - 2
PY  - 2016
SN  - 2379-1381
ER  -