TY  - JOUR
AB  - BACKGROUND: Inflammation and immunity play important roles in the formation of coronary collateral circulation (CCC). The pan-immune-inflammation value (PIV) is a novel marker for evaluating systemic inflammation and immunity. The study aimed to investigate the association between the PIV and CCC formation in patients with chronic total occlusion (CTO). METHODS: This retrospective study enrolled 1150 patients who were diagnosed with CTO through coronary angiographic (CAG) examinations from January 2013 to December 2021 in China. The Cohen-Rentrop criteria were used to catagorize CCC formation: good CCC formation (Rentrop grade 2-3) and poor CCC formation group (Rentrop grade 0-1). Based on the tertiles of the PIV, all patients were classified into three groups as follows: P1 group, PIV ≤ 237.56; P2 group, 237.56< PIV ≤ 575.18; and P3 group, PIV > 575.18. RESULTS: A significant relationship between the PIV and the formation of CCC was observed in our study. Utilizing multivariate logistic regression and adjusting for confounding factors, the PIV emerged as an independent risk factor for poor CCC formation. Notably, the restricted cubic splines revealed a dose-response relationship between the PIV and risk of poor CCC formation. In terms of predictive accuracy, the area under the ROC curve (AUC) for PIV in anticipating poor CCC formation was 0.618 (95% CI: 0.584-0.651, P < 0.001). Furthermore, the net reclassification index (NRI) and integrated discrimination index (IDI) for PIV, concerning the prediction of poor CCC formation, were found to be 0.272 (95% CI: 0.142-0.352, P < 0.001) and 0.051 (95% CI: 0.037-0.065, P < 0.001), respectively. It's noteworthy that both the NRI and IDI values were higher for PIV compared to other inflammatory biomarkers, suggesting its superiority in predictive capacity. CONCLUSIONS: PIV was associated with the formation of CCC. Notably, PIV exhibited potential as a predictor for poor CCC formation and showcased superior predictive performance compared to other complete blood count-based inflammatory biomarkers.
AU  - Zhang, B.*
AU  - Li, Y.*
AU  - Peng, A.*
AU  - Liu, C.*
AU  - Lin, J.
AU  - Feng, Y.*
AU  - Wan, J.*
C1  - 71565
C2  - 56165
CY  - Campus, 4 Crinan St, London N1 9xw, England
TI  - Association between the pan-immune-inflammation value and coronary collateral circulation in chronic total coronary occlusive patients.
JO  - BMC Cardiovasc. Disord.
VL  - 24
IS  - 1
PB  - Bmc
PY  - 2024
ER  - 

TY  - JOUR
AB  - Background: The association between the presence of a diagonal earlobe crease (DEC) and coronary artery disease has been prescribed earlier. However, it is unclear whether patients with acute myocardial infarction (AMI) and DEC have a higher risk of dying. Methods: Study participants were persons with AMI who were included in the KORA Myocardial Infarction Registry Augsburg from August 2015 to December 2016. After taking pictures of both earlobes, two employees independently assessed the severity of DEC in 4°. For analysis, the expression of the DEC was dichotomized. Information on risk factors, severity and therapy of the AMI was collected by interview and from the medical record. Vital status post AMI was obtained by population registries in 2019. The relationship between DEC and survival time was determined using Cox proportional hazards models. Results: Out of 655 participants, 442 (67.5%) showed DEC grade 2/3 and 213 (32.5%) DEC grade 0/1. Median observation period was 3.06 years (5–1577 days). During this period, 26 patients (12.2%) with DEC grade 0/1 and 92 patients (20.8%) with grade 2/3 died (hazard ratio 1.91, 95% confidence interval (CI) 1.23–2.96, p = 0.0037). In the fully adjusted model, patients with DEC grade 2/3 had a 1.48-fold increased risk of death compared to the DEC grade 0/1 patient group (CI 0.94–2.34, p = 0.0897). The fully adjusted model applied for 1-year survival revealed a significant, 2.57-fold hazard ratio of death (CI 1.07–6.17, p = 0.0347) for the patients with DEC grade 2/3. Conclusions: Our results indicate that DEC is independently associated with 1-year AMI survival.
AU  - Thilo, C.*
AU  - Meisinger, C.
AU  - Heier, M.
AU  - von Scheidt, W.*
AU  - Kirchberger, I.
C1  - 63859
C2  - 51729
CY  - Campus, 4 Crinan St, London N1 9xw, England
TI  - Diagonal earlobe crease and long-term survival after myocardial infarction.
JO  - BMC Cardiovasc. Disord.
VL  - 21
IS  - 1
PB  - Bmc
PY  - 2021
ER  - 

TY  - JOUR
AB  - BACKGROUND: Epidemiological studies have repeatedly observed a markedly higher risk for coronary artery disease (CAD) in Scotland as compared to England. Up to now, it is unclear whether environmental or genetic factors might explain this phenomenon. METHODS: Using UK Biobank (UKB) data, we assessed CAD risk, based on the Framingham risk score (FRS) and common genetic variants, to explore the respective contribution to CAD prevalence in Scotland (n = 31,963) and England (n = 317,889). We calculated FRS based on sex, age, body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), antihypertensive medication, smoking status, and diabetes. We determined the allele frequency of published genome-wide significant risk CAD alleles and a weighted genetic risk score (wGRS) for quantifying genetic CAD risk. RESULTS: Prevalence of CAD was 16% higher in Scotland as compared to England (8.98% vs. 7.68%, P < 0.001). However, the FRS only predicted a marginally higher CAD risk (less than 1%) in Scotland (12.5 ± 10.5 vs.12.6 ± 10.6, P = 0.03). Likewise, the overall number of genome-wide significant variants affecting CAD risk (157.6 ± 7.7 and 157.5 ± 7.7; P = 0.12) and a wGRS for CAD (2.49 ± 0.25 in both populations, P = 0.14) were remarkably similar in the English and Scottish population. Interestingly, we observed substantial differences in the allele frequencies of individual risk variants. Of the previously described 163 genome-wide significant variants studied here, 35 variants had higher frequencies in Scotland, whereas 37 had higher frequencies in England (P < 0.001 each). CONCLUSIONS: Neither the traditional risk factors included in the FRS nor a genetic risk score (GRS) based on established common risk alleles explained the higher CAD prevalence in Scotland. However, we observed marked differences in the distribution of individual risk alleles, which emphasizes that even geographically and ethnically closely related populations may display relevant differences in the genetic architecture of a common disease.
AU  - Yang, C.*
AU  - Starnecker, F.*
AU  - Pang, S.*
AU  - Chen, Z.*
AU  - Güldener, U.*
AU  - Li, L.*
AU  - Heinig, M.
AU  - Schunkert, H.*
C1  - 63803
C2  - 51656
CY  - Campus, 4 Crinan St, London N1 9xw, England
TI  - Polygenic risk for coronary artery disease in the Scottish and English population.
JO  - BMC Cardiovasc. Disord.
VL  - 21
IS  - 1
PB  - Bmc
PY  - 2021
ER  - 

TY  - JOUR
AB  - Background: Previous studies have shown that the presence of anemia is associated with increased short-and long-term outcomes in patients with acute myocardial infarction (AMI). This study aims at examining the impact of admission anemia on long-term, all-cause mortality following AMI in patients recruited from a population-based registry. Contrary to most prior studies, we distinguished between patients with mild and moderate to severe anemia. Methods: This prospective study was conducted in 2011 patients consecutively hospitalized for AMI that occurred between January 2005 and December 2008. Patients who survived more than 28 days after AMI were followed up until December 2011. Hemoglobin (Hb) concentration was measured at hospital admission and classified according to the World Health Organization (WHO). Mild anemia was defined as Hb concentration of 11 to < 12 g/dL in women and 11 to < 13 g/dL in men; moderate to severe anemia as Hb concentration of < 11 g/dL. Adjusted Cox regression models were calculated to compare survival in patients with and without anemia. Results: Mild anemia and moderate to severe anemia was found in 183 (9.1%) and 100 (5%) patients, respectively. All-cause mortality after a median follow-up time of 4.2 years was 11.9%. The Cox regression analysis showed significantly increased mortality risks in both patients with mild (HR 1.74, 95% CI 1.23-2.45) and moderate to severe anemia (HR 2.05, 95% CI 1.37-3.05) compared to patients without anemia. Conclusion: This study shows that anemia adversely affects long-term survival following AMI. However, further studies are needed to confirm that anemia can solely explain worse long-term outcomes after AMI.
AU  - Colombo, M.
AU  - Kirchberger, I.
AU  - Amann, U.
AU  - Heier, M.
AU  - Thilo, C.*
AU  - Kuch, B.*
AU  - Peters, A.
AU  - Meisinger, C.
C1  - 53226
C2  - 44403
CY  - London
TI  - Association between admission anemia and long-term mortality in patients with acute myocardial infarction: Results from the MONICA/KORA myocardial infarction registry.
JO  - BMC Cardiovasc. Disord.
VL  - 18
IS  - 1
PB  - Biomed Central Ltd
PY  - 2018
ER  - 

TY  - JOUR
AB  - BackgroundSleep-related investigations in acute myocardial infarction (AMI) patients are rare. The aim of this study was to examine sex-specific associations of patient-reported sleep disturbances within 4weeks before AMI and long-term survival.MethodsFrom a German population-based, regional AMI registry, 2511 men and 828 women, aged 28-74years, hospitalized with a first-time AMI between 2000 and 2008 and still alive after 28days, were included in the study (end of follow-up: 12/2011). Frequency of any sleep disturbances within 4weeks before AMI was inquired by a 6-categorical item summarized to never', sometimes' and nightly'. Cox regression models were calculated.ResultsOver the median follow-up time of 6.1years (IQR: 4.1) sleep disturbances were reported by 32.3% of male and 48.4% of female patients. During the observation period, 318 men (12.7%) and 131 women (15.8%) died. Men who sometimes' had sleep disturbances showed a 56% increased mortality risk compared to those without complaints in an age-adjusted model (HR 1.56; 95%-CI 1.21-2.00). Additional adjustment for confounding variables attenuated the effect to 1.40 (95%-CI 1.08-1.81). Corresponding HRs among women were 0.97 (95%-CI 0.65-1.44) and 0.99 (95%-CI 0.66-1.49). HRs for patients with nightly sleep disturbances did not suggest any association for both sexes.ConclusionsOur study found that nightly sleep disturbances have no influence on long-term survival in male and female AMI patients. Contrary to women, men who reported sometimes sleep disturbances had a higher mortality. Further investigations on this topic taking into account the role of obstructive sleep apnoea are needed.
AU  - Nairz, F.
AU  - Meisinger, C.
AU  - Kirchberger, I.
AU  - Heier, M.
AU  - Thilo, C.*
AU  - Kuch, B.*
AU  - Peters, A.
AU  - Amann, U.
C1  - 54968
C2  - 46017
CY  - Campus, 4 Crinan St, London N1 9xw, England
TI  - Association of sleep disturbances within 4 weeks prior to incident acute myocardial infarction and long-term survival in male and female patients: An observational study from the MONICA/KORA Myocardial Infarction Registry.
JO  - BMC Cardiovasc. Disord.
VL  - 18
IS  - 1
PB  - Bmc
PY  - 2018
ER  - 

TY  - JOUR
AB  - Background: Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall thickness measured by cardiac magnetic resonance (CMR), and potential interactions of hypertension and diabetes. Methods: CMR was performed on 359 participants from a cross-sectional study nested in a population-based cohort (KORA FF4) free of overt cardiovascular disease. Participants were classified according to their glycemic status as either control (normal glucose metabolism), prediabetes or type 2 diabetes. Segmentation of the left ventricle was defined according to the American Heart Association (AHA) 16-segment model. Measurements of wall thickness were obtained at end-diastole and analyzed by linear regression models adjusted for traditional cardiovascular risk factors. Results: LV wall thickness gradually increased from normoglycemic controls to subjects with prediabetes and subjects with diabetes (8.8 ± 1.4 vs 9.9 ± 1.4 vs 10.5 ± 1.6 mm, respectively). The association was independent of hypertension and traditional cardiovascular risk factors (β-coefficient: 0.44 mm for prediabetes and 0.70 mm for diabetes, p-values compared to controls: p = 0.007 and p = 0.004, respectively). Whereas the association of glycemic status was strongest for the mid-cavity segments, the association of hypertension was strongest for the basal segments. Conclusion: Abnormal glucose metabolism, including pre-diabetes, is associated with increased LV wall thickness independent of hypertension.
AU  - Rospleszcz, S.
AU  - Schafnitzel, A.*
AU  - Koenig, W.*
AU  - Lorbeer, R.*
AU  - Auweter, S.*
AU  - Huth, C.
AU  - Rathmann, W.*
AU  - Heier, M.
AU  - Linkohr, B.
AU  - Meisinger, C.
AU  - Hetterich, H.*
AU  - Bamberg, F.*
AU  - Peters, A.
C1  - 54121
C2  - 45304
CY  - Campus, 4 Crinan St, London N1 9xw, England
TI  - Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: A cross-sectional study.
JO  - BMC Cardiovasc. Disord.
VL  - 18
IS  - 1
PB  - Bmc
PY  - 2018
ER  - 

TY  - JOUR
AB  - BACKGROUND: Conflicting with clinical practice guidelines, recent studies demonstrated that serum potassium concentrations (SPC) of ≥4.5 mEq/l were associated with increased mortality in patients with acute myocardial infarction (AMI). This study examined the association between SPC and long-term mortality following AMI in patients recruited from a population-based registry. METHODS: Included in the study were 3347 patients with AMI aged 28-74 years consecutively hospitalized between 1 January 2000 and 31 December 2008 and followed up until 31 December 2011. Patients were categorized into five SPC groups (<3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and ≥5.0 mEq/l). The outcome of the study was all-cause mortality. Cox regression models adjusted for risk factors, co-morbidities and in-hospital treatment were constructed. RESULTS: In our study population, 249 patients (7.4%) had a low SPC (<3.5 mEq/l) and 134 (4.0%) patients had a high SPC (≥5.0 mEq/l). Patients with SPC of ≥5.0 mEq/l had the highest long-term mortality (29.9%) and in the adjusted model, their risk of dying was significantly increased (HR 1.46, 95% CI 1.03 to 2.07) compared to patients with SPC between 4.0 and <4.5 mEq/l. Analyses of increasing observation periods showed a trend towards a higher risk of dying in patients with SPC between 4.5 and <5.0 mEq/l. CONCLUSION: An admission SPC of ≥5.0 mEq/l might be associated with an increased mortality risk in patients with AMI. Patients with an admission SPC between 4.5 and <5.0 mEq/l might have an increased mortality risk in the first few years following AMI.
AU  - Colombo, M.
AU  - Kirchberger, I.
AU  - Amann, U.
AU  - Heier, M.
AU  - Thilo, C.*
AU  - Kuch, B.*
AU  - Peters, A.
AU  - Meisinger, C.
C1  - 51584
C2  - 43314
CY  - London
TI  - Admission serum potassium concentration and long-term mortality in patients with acute myocardial infarction: Results from the MONICA/KORA myocardial infarction registry.
JO  - BMC Cardiovasc. Disord.
VL  - 17
IS  - 1
PB  - Biomed Central Ltd
PY  - 2017
ER  - 

TY  - JOUR
AB  - BACKGROUND: A substantial proportion of patients with acute myocardial infarction (AMI) did not receive invasive therapy, defined as percutaneous coronary intervention and/or coronary artery bypass grafting. Aims of this study were to evaluate predictors of non-invasive therapy in elderly compared to younger AMI patients and to assess the association between invasive therapy and 28-day-case fatality. METHODS: From the German population-based registry, 3475 persons, consecutively hospitalized with an AMI between 2009 and 2012 were included. Data were collected by standardized interviews and chart review. All-cause mortality was assessed on a regular basis. Multivariable logistic regression analyses were conducted. RESULTS: The sample consisted of 1329 patients aged 28-65 years (age category [AC] 1), 1083 aged 65-74 years (AC 2), and 1063 aged 75-84 years (AC 3). The proportion of patients receiving non-invasive therapy was 10.7, 17.7, and 35.8 % in AC 1, 2, and 3, respectively. Predictors of non-invasive therapy in all ACs were non-ST segment elevation MI, bundle branch block, reduced left ventricular ejection fraction, prior stroke, absence of hyperlipidemia, and low creatine kinase. Elderly women (≥65 years) were less likely to receive invasive therapy. Stratifying the models by type of AMI revealed fewer predictors in patients with ST segment elevation MI. Regarding 28-day-case fatality, strong inverse relations with invasive therapy were seen in all AC: odds ratio of 0.35 (95 % confidence interval [CI] 0.15-0.84), 0.45 (95 % CI 0.22-0.92), and 0.39 (95 % CI 0.24-0.63) in AC 1, 2 and 3, respectively. CONCLUSION: In today's real-life patient care we found that predictors of non-invasive therapy were predominantly the same in all age groups, but differed particularly by type of AMI. Further research is necessary to investigate the real reasons for non-invasive therapy, especially among elderly women. Moreover, we confirmed that receiving invasive therapy was inversely associated with 28-day-case fatality independent of age.
AU  - Amann, U.
AU  - Kirchberger, I.
AU  - Heier, M.
AU  - Thilo, C.*
AU  - Kuch, B.*
AU  - Peters, A.
AU  - Meisinger, C.
C1  - 49086
C2  - 41646
CY  - London
TI  - Predictors of non-invasive therapy and 28-day-case fatality in elderly compared to younger patients with acute myocardial infarction: An observational study from the MONICA/KORA Myocardial Infarction Registry.
JO  - BMC Cardiovasc. Disord.
VL  - 16
IS  - 1
PB  - Biomed Central Ltd
PY  - 2016
ER  -