TY  - JOUR
AB  - Aging is a time-related process of functional decline at organelle, cellular, tissue, and organismal level that ultimately limits life. Cellular senescence is a state of permanent growth arrest in response to stress and one of the major drivers of aging and age-related disorders. Senescent cells accumulate with age, and removal of these cells delays age-related disorders in different tissues and prolongs healthy lifespan. One of the most studied aging mechanisms is the accumulation of reactive oxygen species damage in cells, organs, and organisms over time. Elevated oxidative stress is also found in metabolic diseases such as obesity, metabolic syndrome and associated disorders. Moreover, dysregulation of the energy homeostasis is also associated with aging, and many age-related genes also control energy metabolism, with the adipose organ, comprising white, brite, and brown adipocytes, as an important metabolic player in the regulation of whole-body energy homeostasis. This review summarizes transformations in the adipose organ upon aging and cellular senescence and sheds light on the reallocation of fat mass between adipose depots, on the metabolism of white and brown adipose tissue, on the regenerative potential and adipogenic differentiation capacity of preadipocytes, and on alterations in mitochondria and bioenergetics. In conclusion, the aging process is a lifelong, creeping process with gradual decline in (pre-)adipocyte function over time. Thus, slowing down the accumulation of (pre-)adipocyte damage and dysfunction, removal of senescent preadipocytes as well as blocking deleterious compounds of the senescent secretome are protective measures to maintain a lasting state of health at old age.
AU  - Schosserer, M.*
AU  - Grillari, J.*
AU  - Wolfrum, C.*
AU  - Scheideler, M.
C1  - 52553
C2  - 44071
SP  - 229–236 
TI  - Age-induced changes in white, brite, and brown adipose depots: A mini-review.
JO  - Gerontology
VL  - 64
PY  - 2018
SN  - 0016-898X
ER  - 

TY  - JOUR
AB  - Background: Gait changes at older ages are a strong predictor of a decline in lower extremity functions. However, large population-based studies assessing gait parameters in various gait tasks are lacking. Objective: We investigated the relationship of age, the use of mobility aids and being fitted with an endoprosthesis with selected gait parameters, assessed in different walking tasks. Methods: In the population-based KORA-Age study, data from 907 men and women aged 65-91 years were obtained using the validated electronic walkway system GAITRite, which quantifies spatiotemporal gait parameters in the measurement range of a 488 x 61 cm walkway mat. Participants completed three walking tasks at different speeds (normal, slow and fast) and a fourth walking task at normal speed with the additional task of counting backwards (dual-task walking). Additionally, the impact of endoprostheses (hip or knee) and mobility aids was assessed. Results: The highest relative age-related decline for velocity was observed during dual-task walking (26.1% for men and 23.4% for women) and for step length during fast walking (20.2 and 14.4%) when comparing participants aged <70 years with those aged >= 85 years. Weaker performances for velocity, cadence and step length were observed among women with knee or hip endoprostheses (fast walking speed) (p < 0.05). Across all walking tasks, significant differences between mobility aid users and nonusers were observed for velocity and step length among both men and women (p < 0.05). Conclusion: A decline in gait performance is most notable in fast speed and dual-task walking, in age-related endoprosthesis and mobility aid analyses. The marked relative decrease in gait parameters in these difficult gait tasks may be attributed to lacking resources for compensation among the elderly.
AU  - Autenrieth, C.S.
AU  - Karrasch, S.*
AU  - Heier, M.
AU  - Gorzelniak, L.
AU  - Ladwig, K.-H.
AU  - Peters, A.
AU  - Döring, A.
C1  - 23621
C2  - 31237
SP  - 165-173
TI  - Decline in gait performance detected by an electronic walkway system in 907 older adults of the population-based KORA-age study.
JO  - Gerontology
VL  - 59
IS  - 2
PB  - Karger
PY  - 2013
SN  - 0016-898X
ER  - 

TY  - JOUR
AB  - As populations become older all over the world, allergic reactions in elderly persons will be encountered more often in the future. Up to now, there has been much more literature on allergy prevalence in childhood than on allergy diseases in adults. As a challenge to epidemiology, allergic disorders in elderly persons may be masked by various symptoms corresponding with a general age-induced decline of physiological functions, including vitamin D deficiency and gastric pH increase. How much structural and functional changes (e.g. low calcitriol level) or effects caused by drugs (e.g. acid-suppression medications) in addition to immunological alterations encountered at old age are responsible for this development is a matter of debate. In the years ahead, the problem of allergy in adulthood and especially in the elderly will become more pronounced.
AU  - Möhrenschlager, M.*
AU  - Ring, J.
C1  - 6036
C2  - 28608
SP  - 33-36
TI  - Food allergy: An increasing problem for the elderly.
JO  - Gerontology
VL  - 57
IS  - 1
PB  - Karger
PY  - 2011
SN  - 0016-898X
ER  -