TY  - JOUR
AB  - The treatment of gliomas became more sophisticated during the last decades. As by now, adjuvant treatment after maximum safe resection is considered an important and effective treatment strategy in most gliomas, yet the decision is based on several factors. This review summarizes the available evidence for the current adjuvant treatment algorithms with a focus on the impact on the survival of glioma patients. The review is based on the current guidelines, but it also includes new insights which have not yet been included into the official guidelines.
AU  - Straube, C.*
AU  - Schmidt-Graf, F.*
AU  - Wiestler, B.*
AU  - Zimmer, C.*
AU  - Meyer, B.*
AU  - Combs, S.E.
C1  - 54950
C2  - 45956
CY  - Corso Bramante 83-85 Int Journals Dept., 10126 Turin, Italy
SP  - 179-186
TI  - The algorithms of adjuvant therapy in gliomas and their effect on survival.
JO  - J. Neurosurg. Sci.
VL  - 63
IS  - 2
PB  - Edizioni Minerva Medica
PY  - 2018
SN  - 0390-5616
ER  - 

TY  - JOUR
AB  - Brain metastases are a common problem in solid malignancies and still represent a major cause of morbidity and mortality. With the ongoing improvement in systemic therapies, the expectations on the efficacy of brain metastases directed treatment options are growing. As local therapies against brain metastases continue to evolve, treatment patterns have shifted from a palliative "one-treatment-fits-all" towards an individualized, patient adapted approach. In this article we review the evidence for stereotactic radiation treatment based on the current literature. Stereotactic radiosurgery (SRS) as a local high precision approach for the primary treatment of asymptomatic brain metastases has gained wide acceptance. It leads to lasting tumor control with only minor side effects compared to whole brain radiotherapy, since there is only little dose delivered to the healthy brain. The same holds true for hypofractionated stereotactic radiotherapy (HFSRT) for large metastases or for lesions close to organs at risk (e.g. the brainstem). New treatment indications such as neoadjuvant SRS followed by surgical resection or postoperative local therapy to the resection cavity show promising data and are also highlighted in this manuscript. With the evolution of local treatment options, optimal patient selection becomes more and more crucial. This article aims to aid decision making by outlining prognostic factors, treatment techniques and indications and common dose prescriptions.
AU  - Specht, H.M.*
AU  - Combs, S.E.
C1  - 49865
C2  - 41825
CY  - Turin
SP  - 357-366
TI  - Stereotactic radiosurgery of brain metastases.
JO  - J. Neurosurg. Sci.
VL  - 60
IS  - 3
PB  - Edizioni Minerva Medica
PY  - 2016
SN  - 0390-5616
ER  -