TY  - JOUR
AB  - Gut bacteria play an essential role in the human body by regulating multiple functions, producing essential metabolites, protecting against pathogen invasion, and much more. Conversely, changes in their community structure are linked to several gastrointestinal (GI) and non-GI conditions. Fortunately, these bacteria are amenable to external perturbations, but we need specific tools for their safe manipulation as nonspecific changes can cause unpredicted long-term consequences. Here, we mainly discuss recent advances in cultivation-independent technologies and argue their relevance to different key steps, that is, identifying the modulation targets and developing phage-based tools to precisely modulate gut bacteria and restore a sustainable microbiome in humans. We finally suggest multiple modulating strategies for different dysbiosis-associated diseases.
AU  - Khan Mirzaei, M.
AU  - Deng, L.
C1  - 62089
C2  - 50581
CY  - The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
SP  - 131-142
TI  - New technologies for developing phage-based tools to manipulate the human microbiome.
JO  - Trends Microbiol.
VL  - 30
IS  - 2
PB  - Elsevier Sci Ltd
PY  - 2022
SN  - 0966-842X
ER  - 

TY  - JOUR
AB  - In this review we provide an overview of current challenges and advances in bacteriophage research within the growing field of viromics. In particular, we discuss, from a human virome study perspective, the current and emerging technologies available, their limitations in terms of de novo discoveries, and possible solutions to overcome present experimental and computational biases associated with low abundance of viral DNA or RNA. We summarize recent breakthroughs in metagenomics assembling tools and single-cell analysis, which have the potential to increase our understanding of phage biology, diversity, and interactions with both the microbial community and the human body. We expect that these recent and future advances in the field of viromics will have a strong impact on how we develop phage-based therapeutic approaches.
AU  - Khan Mirzaei, M.
AU  - Xue, J.
AU  - Costa, R.
AU  - Ru, J.
AU  - Schulz, S.
AU  - Taranu, Z.E.*
AU  - Deng, L.
C1  - 59608
C2  - 48879
CY  - The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
SP  - 171-181
TI  - Challenges of studying the human virome – relevant emerging technologies.
JO  - Trends Microbiol.
VL  - 29
IS  - 2
PB  - Elsevier Sci Ltd
PY  - 2021
SN  - 0966-842X
ER  - 

TY  - JOUR
AB  - The microbiome research field is rapidly evolving, but the required biobanking infrastructure is currently fragmented and not prepared for the biobanking of microbiomes. The rapid advancement of technologies requires an urgent assessment of how biobanks can underpin research by preserving microbiome samples and their functional potential.
AU  - Ryan, M.J.*
AU  - Schloter, M.
AU  - Berg, G.*
AU  - Kostic, T.*
AU  - Kinkel, L.L.*
AU  - Eversole, K.*
AU  - Macklin, J.A.*
AU  - Schelkle, B.*
AU  - Kazou, M.*
AU  - Sarand, I.*
AU  - Singh, B.K.*
AU  - Fischer, D.
AU  - Maguin, E.*
AU  - Ferrocino, I.*
AU  - Lima, N.*
AU  - McClure, R.S.*
AU  - Charles, T.C.*
AU  - de Souza, R.S.C.*
AU  - Kiran, G.S.*
AU  - Krug, H.L.*
AU  - Taffner, J.*
AU  - Roume, H.*
AU  - Selvin, J.*
AU  - Smith, D.*
AU  - Rybakova, D.*
AU  - Sessitsch, A.*
C1  - 60017
C2  - 49347
CY  - The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
SP  - 89-92
TI  - Development of microbiome biobanks – challenges and opportunities.
JO  - Trends Microbiol.
VL  - 29
IS  - 2
PB  - Elsevier Sci Ltd
PY  - 2021
SN  - 0966-842X
ER  - 

TY  - JOUR
AB  - During a long history of coevolution, herpesviruses have reached a fine-tuned balance with their hosts, allowing them to successfully persist and spread to new hosts without causing too much damage. Only under certain circumstances, as in neonates or immunocompromised individuals, they may cause serious diseases. The delicate balance between herpesviruses and their hosts results from interactions of a great variety of viral and cellular factors which together shape the tropism for a particular host, tissue, or cell. Understanding these interactions will provide insight into the viral life cycle and cell biology in general. Moreover, it will also facilitate comprehension of herpesvirus pathogenesis, enabling the development of new strategies to combat herpesviruses in cases where they cause disease.
AU  - Adler, B.*
AU  - Sattler, C.
AU  - Adler, H.
C1  - 50142
C2  - 42030
TI  - Herpesviruses and their host cells: A successful liaison.
JO  - Trends Microbiol.
PY  - 2016
SN  - 0966-842X
ER  -