Koc-Gunel, S.* et al. Targeting fibroblast-endothelial interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics. JCI insight 10:e187899 (2025)
Rüeger, S.* et al. Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells. JCI insight 10:e180309 (2025)
Wittenzellner, K.* et al. Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time. JCI insight 10:e169105 (2025)
Burgy, O.* et al. Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis. JCI insight 9:e168889 (2024)
Sui, J.* et al. Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD. JCI insight 9:e180239 (2024)
Bajwa, P.* et al. Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis. JCI insight 8:17 (2023)
Khajavi, N.* et al. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity. JCI insight 8:e163397 (2023)
Rohwedder, I.* et al. A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny. JCI insight 8:e155968 (2023)
Wang, Q. et al. Metabolic heterogeneity in adrenocortical carcinoma impacts patient outcomes. JCI insight 8:18 (2023)
Buck, A. ; Prade, V.M. ; Kunzke, T. ; Erben, R.G.* & Walch, A.K. Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice. JCI insight 7:e162138 (2022)
Hong, L.* et al. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI insight 7:e156046 (2022)
Kullmann, S. et al. Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI insight 7:e161498 (2022)
Li, Y.* et al. Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases. JCI insight 7:e157035 (2022)
Modak, M.* et al. CD206+ tumor-associated macrophages cross-present tumor antigen and drive anti-tumor immunity. JCI insight 7:e155022 (2022)
Dietz, B.* et al. Detection of diabetes from whole-body MRI using deep learning. JCI insight 6:e146999 (2021)
Kaiser, R.* et al. Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19. JCI insight 6:e150862 (2021)
Willmes, D.M. et al. The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. JCI insight 6:e136083 (2021)
Belle, J.I.* et al. MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction. JCI insight 5:e125690 (2020)
Panzer, J.K. et al. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI insight 5:134525 (2020)
Weber, J.* et al. TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. JCI insight 5:e134464 (2020)
Kaesler, S.* et al. Targeting tumor-resident mast cells for effective anti-melanoma immune responses. JCI insight 4:e125057 (2019)
Lodd, E.* et al. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight 4:e126154 (2019)
Murakami, M.* et al. In situ metabolomics of aldosterone-producing adenomas. JCI insight 4:e130356 (2019)
Smirnova, N.F. et al. Inhibition of B cell–dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation. JCI insight 4:123971 (2019)
Houssaini, A. et al. mTOR pathway activation drives lung cell senescence and emphysema. JCI insight 3:93203 (2018)
Mehdi, A.M.* et al. A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI insight 3:e98212 (2018)
Oshima, M.* et al. Virus-like infection induces human β cell dedifferentiation. JCI insight 3:97732 (2018)
Sakkou, M.* et al. Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. JCI insight 3:98864 (2018)
Arlt, W.* et al. Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI insight 2:93136 (2017)
Simon, J.J.* et al. Integration of homeostatic signaling and food reward processing in the human brain. JCI insight 2:e92970 (2017)
Ge, L.* et al. miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways. JCI insight 1:e90301 (2016)