TY  - JOUR
AU  - Bork, J.*
AU  - Markus, M.R.P.*
AU  - Ewert, R.*
AU  - Nauck, M.*
AU  - Templin, C.*
AU  - Voelzke, H.*
AU  - Kastenmüller, G.
AU  - Artati, A.
AU  - Adamski, J.
AU  - Doerr, M.*
AU  - Friedrich, N.*
AU  - Bahls, M.*
C1  - 74175
C2  - 57263
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
TI  - The metabolic fingerprint of cardiorespiratory fitness (vol 35, e70034, 2025).
JO  - Scand. J. Med. Sci. Sports
VL  - 35
IS  - 4
PB  - Wiley
PY  - 2025
SN  - 0905-7188
ER  - 

TY  - JOUR
AB  - High cardiorespiratory fitness (CRF) is associated with better overall health. This study aimed to find a metabolic signature associated with CRF to identify health-promoting effects. CRF based on cardiopulmonary exercise testing, targeted and untargeted metabolomics approaches based on mass spectrometry, and clinical data from two independent cohorts of the Study of Health in Pomerania (SHIP) were used. Sex-stratified linear regression models were adjusted for age, smoking, and height to relate CRF with individual metabolites. A total of 132 (SHIP-START-2: 483 men with a median age of 58 years and 450 women with a median age of 56 years) and 118 (SHIP-TREND-0: 341 men and 371 women both with a median age of 51 years) metabolites were associated with CRF. Lipids showed bidirectional relations to CRF independent of sex. Specific subsets of sphingomyelins were positively related to CRF in men (SM (OH) C14:1, SM(OH)C22:2 SM C16:0, SM C20:2 SM(OH)C24:1) and inversely in women (SM C16:1, SM C18:0, SM C18:1). Metabolites involved in energy production (citrate and succinylcarnitine) were only associated with CRF in men. In women, xenobiotics (hippurate, stachydrine) were related to CRF. The sex-specific metabolic signature of CRF is influenced by sphingomyelins, energy substrates, and xenobiotics. The greater effect estimates seen in women may emphasize the important role of CRF in maintaining metabolic health. Future research should explore how this profile changes with different types of exercise interventions or diseases in diverse populations and how these metabolites could be implemented in primary prevention settings.
AU  - Bork, J.*
AU  - Markus, M.R.P.*
AU  - Ewert, R.*
AU  - Nauck, M.*
AU  - Templin, C.*
AU  - Völzke, H.*
AU  - Kastenmüller, G.
AU  - Artati, A.
AU  - Adamski, J.
AU  - Dörr, M.*
AU  - Friedrich, N.*
AU  - Bahls, M.*
C1  - 73661
C2  - 56862
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
TI  - The metabolic signature of cardiorespiratory fitness.
JO  - Scand. J. Med. Sci. Sports
VL  - 35
IS  - 3
PB  - Wiley
PY  - 2025
SN  - 0905-7188
ER  - 

TY  - JOUR
AB  - The purpose of this study was to examine whether physical activity (PA) and muscular strength (MS) are related to polypharmacy. Our cross-sectional analysis was based on 711 patients with multimorbidity (MMB), aged 65-94years, who participated in the KORA-Age study. Participants underwent a face-to-face interview and extensive physical examinations including anthropometric measurements, registration of chronic diseases, determination of health-related behaviors (smoking, alcohol intake, physical activity, etc.), collection of blood samples and measurement of hand-grip strength. PPha was defined as the use of >4 drugs and MMB as having 2 of 13 chronic diseases. Prevalence of PPha was 44.6% (n=317), and a significant difference was found in the number of drugs used between participants with and without PPha (7.2 +/- 2.1 vs 2.5 +/- 1.2, P<.001). Patients in the lower compared to the upper tertile of physical activity had a significantly increased odds to be on PPha (OR: 1.64, 95% CI: 1.05-2.56, P=.031) after controlling for age, gender, BMI, family status, education, alcohol intake, smoking habits, number of diseases, hs-CRP, and telomere length. On the contrary, no significant association between muscular strength and PPha was found (OR: 1.04, 95% CI: 0.66-1.63, P=.873) after multivariable adjustment. Among older persons with MMB, lower levels of physical activity, but not low muscular strength, are associated with higher odds of PPha. Increasing the levels of physical activity appears to be highly recommended in order to potentially reduce the risk of PPha among multimorbid persons aged 65 and older.
AU  - Volaklis, K.A.*
AU  - Thorand, B.
AU  - Peters, A.
AU  - Halle, M.*
AU  - Heier, M.
AU  - Strasser, B.*
AU  - Amann, U.
AU  - Ladwig, K.-H.
AU  - Schulz, H.
AU  - Koenig, W.*
AU  - Meisinger, C.
C1  - 50780
C2  - 42883
CY  - Hoboken
SP  - 604-612
TI  - Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age study.
JO  - Scand. J. Med. Sci. Sports
VL  - 28
IS  - 2
PB  - Wiley
PY  - 2018
SN  - 0905-7188
ER  -