TY  - JOUR
AB  - Magnetoencephalography (MEG) has been successfully applied to record fetal auditory (auditory evoked response [AER]) and visual evoked responses (VER). In this study, we report the AER and VER development trajectory by tracking the evoked response detectability and latency from recordings starting at 27 weeks of gestation in pregnancies classified as high risk. Fetal MEG and ultrasound recordings were performed on 158 pregnant women, and the total number of fetal auditory and visual tests conducted was 321 and 237, respectively. The overall evoked response analysis showed 237 AER (73.8%) and 164 VER detections (69.2%). The mean AER latency was 290.7 (SD125.5) ms and the mean VER latency was 293.7 (SD114.5) ms. The rate of decrease (95% confidence limits) in average AER and VER first-peak latency between 100-350 ms was 1.97 (-1.86, +5.81) ms/week and 1.35 (-3.83, +6.53) ms/week, respectively. This trend in high-risk fetuses conforms to the general trajectory of decrease in latency with gestational age progression, even though this decrease was non-significant, as reported in the case of normal growing fetuses. Although there was a significant difference in detection rates between male and female fetuses, this was not reflected in either latency values or the sensory modality applied. Furthermore, the main factors that had the most significant effect on response detectability included the presence of intervening layers of adipose tissue between the fetal head and stimulus source and an increase in the maternal body mass index.
AU  - Eswaran, H.*
AU  - Lau, C.*
AU  - Murphy, P.*
AU  - Siegel, E.R.*
AU  - Preissl, H.
AU  - Lowery, C.*
C1  - 59679
C2  - 48927
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 5-15
TI  - Tracking evoked responses to auditory and visual stimuli in fetuses exposed to maternal high-risk conditions.
JO  - Dev. Psychobiol.
VL  - 63
IS  - 1
PB  - Wiley
PY  - 2021
SN  - 0012-1630
ER  - 

TY  - JOUR
AB  - Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.
AU  - TEDDY Study Group (Roth, R.
AU  - Strauss, E.)
AU  - Baxter, J.*
AU  - Vehik, K.*
AU  - Hopkins, D.*
AU  - Killian, M.*
AU  - Gesualdo, P.*
AU  - Melin, J.*
AU  - Simell, B.*
AU  - Lernmark, A.*
AU  - Johnson, S.B.*
C1  - 51210
C2  - 43102
CY  - Hoboken
SP  - 658-667
TI  - The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study.
JO  - Dev. Psychobiol.
VL  - 59
IS  - 5
PB  - Wiley
PY  - 2017
SN  - 0012-1630
ER  -