TY  - JOUR
AB  - Allergy is an ever-evolving group of disorders, which includes asthma, atopic dermatitis, rhinitis and food allergies and that currently affects over 1 billion people worldwide. This group of disorders has exploded in incidence since around the start of the 20th century, implying that genetics is not solely responsible for its development but that environmental factors have an important role. Here, Fabio Luciani and Jonathan Coquet, in their role as editors at Immunology & Cell Biology, asked nine prominent researchers in the field of allergy to define the term ‘allergy’, discuss the role of genetics and the environment, nominate the most important discoveries of the past decade and describe the best strategies to combat allergy at the population level going forward.
AU  - Melén, E.*
AU  - Lambrecht, B.N.*
AU  - Lloyd, C.M.*
AU  - Rothenberg, M.E.*
AU  - Kabashima, K.*
AU  - Luciani, F.*
AU  - Coquet, J.M.*
AU  - Ober, C.*
AU  - Nawijn, M.C.*
AU  - Platts-Mills, T.*
AU  - von Mutius, E.
C1  - 68287
C2  - 54717
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 936-946
TI  - A conversation on allergy: Recognizing the past and looking to the future.
JO  - Immunol. Cell Biol.
VL  - 101
IS  - 10
PB  - Wiley
PY  - 2023
SN  - 0818-9641
ER  - 

TY  - JOUR
AB  - Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least in part, by IL-4-activated macrophages that bind and trap larvae in the lung. However, it is still not clear how host macrophages recognize the parasite. We utilized an in vitro co-culture system of bone marrow-derived macrophages and Nb infective larvae to screen for the possible ligand-receptor pair involved in macrophage attack of larvae. Competitive binding assays revealed an important role for β-glucan recognition in the process. We further identified a role for CD11b and the non-classical pattern recognition receptor ephrin-A2 (EphA2), but not the highly expressed β-glucan dectin-1 receptor, in this process of recognition. This work raises the possibility that parasitic nematodes synthesize β-glucans and identifies CD11b and Ephrin-A2 as important pattern recognition receptors involved in the host recognition of these evolutionary old pathogens. To our knowledge, this is the first time that EphA2 has been implicated in immune responses to a helminth.
AU  - Bouchery, T.*
AU  - Volpe, B.*
AU  - Doolan, R.*
AU  - Coakley, G.*
AU  - Moyat, M.*
AU  - Esser-von Bieren, J.
AU  - Wickramasinghe, L.C.*
AU  - Hibbs, M.L.*
AU  - Sotillo, J.*
AU  - Camberis, M.*
AU  - Le Gros, G.*
AU  - Khan, N.*
AU  - Williams, D.*
AU  - Harris, N.*
C1  - 64371
C2  - 52212
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 223-234
TI  - β-glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping.
JO  - Immunol. Cell Biol.
VL  - 100
IS  - 4
PB  - Wiley
PY  - 2022
SN  - 0818-9641
ER  - 

TY  - JOUR
AB  - The role of RNA-binding proteins of the CCCH-containing family in regulating pro-inflammatory cytokine production and inflammation is increasingly recognized. We have identified ZC3H12C (Regnase-3) as a potential post-transcriptional regulator of Tumor necrosis factor expression and have investigated its role in vivo by generating Zc3h12c-deficient mice that express GFP instead of ZC3H12C. Zc3h12c-deficient mice develop hypertrophic lymph nodes. In the immune system, ZC3H12C expression is mostly restricted to the dendritic cell (DC) populations, and we show that DC-restricted ZC3H12C depletion is sufficient to cause lymphadenopathy. ZC3H12C can regulate Tnf mRNA stability via its RNAse activity in vitro, and we confirmed the role of Tnf in the development of lymphadenopathy. Finally, we found that loss of ZC3H12C did not impact the outcome of skin inflammation in the imiquimod-induced murine model of psoriasis, despite Zc3h12c being identified as a risk factor for psoriasis susceptibility in several GWAS studies. Our data suggest a role for ZC3H12C in DC-driven skin homeostasis.
AU  - Clayer, E.
AU  - Frank, D.*
AU  - Anderton, H.*
AU  - Zhang, S.*
AU  - Kueh, A.*
AU  - Heim, V.*
AU  - Nutt, S.L.*
AU  - Chopin, M.*
AU  - Bouillet, P.*
C1  - 64127
C2  - 52101
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 160-173
TI  - ZC3H12C expression in DCs is necessary to prevent lymphadenopathy of skin-draining lymph nodes.
JO  - Immunol. Cell Biol.
VL  - 100
IS  - 3
PB  - Wiley
PY  - 2022
SN  - 0818-9641
ER  - 

TY  - JOUR
AB  - Trauma or infection can result in tissue damage, which needs to be repaired in a well-orchestrated manner to restore tissue function and homeostasis. Lipid mediators derived from arachidonic acid (termed eicosanoids) play central and versatile roles in the regulation of tissue repair. Here, I summarize the current state-of the-art regarding the functional activities of eicosanoids in tissue repair responses during homeostasis and disease. I also describe how eicosanoids are produced during tissue damage and repair in a time-, cell- and tissue-dependent fashion. In particular, recent insights into the roles of eicosanoids in epithelial barrier repair are reviewed. Furthermore, the distinct roles of different eicosanoids in settings of pathological tissue repair such as chronic wounds, scarring or fibrosis are discussed. Finally, an outlook is provided on how eicosanoids may be targeted by future therapeutic strategies to achieve physiological tissue repair and prevent scarring and loss of tissue function in various disease contexts.
AU  - Esser-von Bieren, J.
C1  - 55327
C2  - 46307
SP  - 279-288
TI  - Eicosanoids in tissue repair.
JO  - Immunol. Cell Biol.
VL  - 97
IS  - 3
PY  - 2019
SN  - 0818-9641
ER  - 

TY  - JOUR
AB  - Activation-induced cytidine deaminase (AID) is required for the immunoglobulin diversification processes of somatic hypermutation, gene conversion and class-switch recombination. The targeting of AID's deamination activity is thought to be a combination of cis- and trans-acting elements, but has not been fully elucidated. Deletion analysis of putative proximal cis-regulatory motifs, while helpful, fails to identify additive versus cumulative effects, redundancy, and may create new motifs where none previously existed. In contrast, gain-of-function analysis can be more insightful with fewer of the same drawbacks and the output is a positive result. Here, we show five defined DNA regions of the avian Ig locus that are sufficient to confer events of hypermutation to a target gene. In our analysis, the essential cis-targeting elements fully reconstituted diversification of a transgene under heterologous promotion in the avian B-cell line DT40. Furthermore, to the best of our knowledge two of the five regions we report on here have not previously been described as individually having an influence on somatic hypermutation.
AU  - Caldwell, R.B.
AU  - Braselmann, H.
AU  - Heuer, S.
AU  - Schötz, U.*
AU  - Zitzelsberger, H.
C1  - 53413
C2  - 44857
CY  - 111 River St, Hoboken 07030-5774, Nj Usa
SP  - 948-957
TI  - Gain-of-function analysis of cis-acting diversification elements in DT40 cells.
JO  - Immunol. Cell Biol.
VL  - 96
IS  - 9
PB  - Wiley
PY  - 2018
SN  - 0818-9641
ER  -