TY  - JOUR
AB  - Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
AU  - Kalel, V.C.*
AU  - Mäser, P.*
AU  - Sattler, M.
AU  - Erdmann, R.*
AU  - Popowicz, G.M.
C1  - 54821
C2  - 45935
CY  - 84 Theobalds Rd, London Wc1x 8rr, England
SP  - 116-122
TI  - Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.
JO  - Curr. Opin. Microbiol.
VL  - 46
PB  - Current Biology Ltd
PY  - 2018
SN  - 1369-5274
ER  -