TY  - JOUR
AB  - he German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the “Biologischer Arbeitsstoff‐Referenzwert” (BAR) as well as the exposure equivalents for carcinogenic substances (EKA) for arsenic and inorganic arsenic compounds (with the exception of arsenic hydride). Available publications are described in detail. The quantification of the various arsenic species is essential to understand the hazardous potential of the arsenic compounds which differ highly in their toxicity. Therefore the BAR for the sum of different arsenic species is no longer valid. Considering published data from occupational not exposed persons, new BAR for the arsenic species of 0.5 µg/l urine for arsenic (+III), 0.5 µg/l urine for arsenic (+V), 2 µg/l urine for monomethylarsonic acid (MMA) and 10 µg/l urine for dimethylarsinic acid (DMA) were evaluated. The differentiation of arsenic species now allows for the estimation of the individual health risks taking into account special influences like seafood consumption. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts. Data of a correlation of arsenic in the air and the sum of the arsenic species in urine were considered for the evaluation of the exposure equivalents for carcinogenic substances. This correlation is in good accordance with the EKA correlation of arsenic trioxide, which is based on former studies in which also the urinary concentrations of the sum of As (+III), As (+V), MMA and DMA were measured. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts.
AU  - Ochsmann, E.*
AU  - Göen, T.*
AU  - Michalke, B.
AU  - Weistenhöfer, W.*
AU  - Klotz, K.*
AU  - Drexler, H.*
AU  - Hartwig, A.*
C1  - 54946
C2  - 45952
SP  - 2030-2040
TI  - Addendum to arsenic and inorganic arsenic compounds (with the exception of arsine).
JO  - MAK Coll. Occup. Health Saf.
VL  - 3
IS  - 4
PY  - 2018
SN  - 2509-2383
ER  - 

TY  - JOUR
AB  - The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The analytical method described hereinafter permits the simple and specific determination of the arsenic species arsenic (III) (As3+), arsenic (V) (As5+), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and arsenobetaine in urine. The limits of quantitation allow the quantification of the above‐mentioned arsenic species in both occupational and environmental medicine. To this end, the arsenic species are separated by anion‐exchange high‐performance liquid chromatography (anion‐exchange HPLC) and detected by inductively coupled plasma mass spectrometry (ICP‐MS). Sample preparation is done by diluting the urine with water. Calibration is performed using either single or mixed standards of the different arsenic species or using the standard addition method. The method was extensively validated and the reliability data were confirmed by an independent laboratory, which has established and cross‐checked the whole procedure.  
AU  - Schramel, P.
AU  - Michalke, B.
AU  - Emons, H.*
AU  - Göen, T.*
AU  - Hartwig, A.*
C1  - 54945
C2  - 45951
SP  - 2186-2207
TI  - Arsenic and arsenic compounds – Determination of arsenic species (As(III), As(V), monomethylarsonic acid, dimethylarsinic acid and arsenobetaine) in urine by HPLC‐ICP‐MS [Biomonitoring Methods, 2018].
JO  - MAK Coll. Occup. Health Saf.
VL  - 3
IS  - 4
PY  - 2018
SN  - 2509-2383
ER  -