TY  - JOUR
AB  - BACKGROUND: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. OBJECTIVE: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for survival and incidence-prevalence biases. METHODS: We used summary statistics from publicly available studies to estimate the association of genetic polymorphisms with lifestyle behaviors, and from Courage-PD (7,369 cases, 7,018 controls; European ancestry) to estimate the association of these variants with PD. We used the inverse-variance weighted method to compute odds ratios (ORIVW) of PD and 95%confidence intervals (CI). Significance was determined using a Bonferroni-corrected significance threshold (p = 0.017). RESULTS: We found a significant inverse association between smoking initiation and PD (ORIVW per 1-SD increase in the prevalence of ever smoking = 0.74, 95%CI = 0.60-0.93, p = 0.009) without significant directional pleiotropy. Associations in participants ≤67 years old and cases with disease duration ≤7 years were of a similar size. No significant associations were observed for alcohol and coffee drinking. In reverse MR, genetic liability toward PD was not associated with smoking or coffee drinking but was positively associated with alcohol drinking. CONCLUSION: Our findings are in favor of an inverse association between smoking and PD that is not explained by reverse causation, confounding, and survival or incidence-prevalence biases. Genetic liability toward PD was positively associated with alcohol drinking. Conclusions on the association of alcohol and coffee drinking with PD are hampered by insufficient statistical power.
AU  - Domenighetti, C.*
AU  - Sugier, P.E.*
AU  - Sreelatha, A.A.K.*
AU  - Schulte, C.*
AU  - Grover, S.*
AU  - Mohamed, O.*
AU  - Portugal, B.*
AU  - May, P.*
AU  - Bobbili, D.R.*
AU  - Radivojkov-Blagojevic, M.
AU  - Lichtner, P.
AU  - Singleton, A.B.*
AU  - Hernandez, D.G.*
AU  - Edsall, C.*
AU  - Mellick, G.D.*
AU  - Zimprich, A.*
AU  - Pirker, W.*
AU  - Rogaeva, E.*
AU  - Lang, A.E.*
AU  - Kõks, S.*
AU  - Taba, P.*
AU  - Lesage, S.*
AU  - Brice, A.*
AU  - Corvol, J.C.*
AU  - Chartier-Harlin, M.C.*
AU  - Mutez, E.*
AU  - Brockmann, K.*
AU  - Deutschländer, A.B.*
AU  - Hadjigeorgiou, G.M.*
AU  - Dardiotis, E.*
AU  - Stefanis, L.*
AU  - Simitsi, A.M.*
AU  - Valente, E.M.*
AU  - Petrucci, S.*
AU  - Duga, S.*
AU  - Straniero, L.*
AU  - Zecchinelli, A.*
AU  - Pezzoli, G.*
AU  - Brighina, L.*
AU  - Ferrarese, C.*
AU  - Annesi, G.*
AU  - Quattrone, A.*
AU  - Gagliardi, M.*
AU  - Matsuo, H.*
AU  - Kawamura, Y.*
AU  - Hattori, N.*
AU  - Nishioka, K.*
AU  - Chung, S.J.*
AU  - Kim, Y.J.*
AU  - Kolber, P.*
AU  - van de Warrenburg, B.P.*
AU  - Bloem, B.R.*
AU  - Aasly, J.O.*
AU  - Toft, M.F.*
AU  - Pihlstrm, L.*
AU  - Guedes, L.C.*
AU  - Ferreira, J.J.*
AU  - Bardien, S.*
AU  - Carr, J.A.*
AU  - Tolosa, E.*
AU  - Ezquerra, M.*
AU  - Pastor, P.*
AU  - Diez-Fairen, M.*
AU  - Wirdefeldt, K.*
AU  - Pedersen, N.L.*
AU  - Ran, C.*
AU  - Belin, A.C.*
AU  - Puschmann, A.J.*
AU  - Hellberg, C.*
AU  - Clarke, C.E.*
AU  - Morrison, K.E.*
AU  - Tan, M.*
AU  - Krainc, D.*
AU  - Burbulla, L.F.*
AU  - Farrer, M.J.*
AU  - Krüger, R.*
AU  - Gasser, T.*
AU  - Sharma, M.*
AU  - Elbaz, A.*
C1  - 63286
C2  - 51453
CY  - Nieuwe Hemweg 6b, 1013 Bg Amsterdam, Netherlands
SP  - 267-282
TI  - Mendelian randomisation study of smoking, alcohol, and coffee drinking in relation to parkinson's disease.
JO  - J. Parkinsons Dis.
VL  - 12
IS  - 1
PB  - Ios Press
PY  - 2022
SN  - 1877-7171
ER  - 

TY  - JOUR
AB  - BACKGROUND: Quality of life (QoL) of persons with Parkinson's disease (PD) is diminished by (non-)motor symptoms, that require personalized care. Parkinson Nurses (PN) may be pivotal promoting tailored care offerings. This systematic review and meta-analysis investigates PD care models and aims at furnishing current concepts of PN to offer personalized care. OBJECTIVE: The purpose of this study is to identify the various roles and functions that PN may hold for personalized PD care. METHODS: We performed a systematic literature review, utilizing: PubMed, Web of Science, The Cochrane Library, and PsycINFO. The review qualitatively evaluated articles, which described personalized care models involving PNs and was guided by the personalized care management model. A meta-analysis compared patient-reported QoL (quantified using the 39-item Parkinson's Disease Questionnaire) between personalized care interventions involving PN versus standard care with. RESULTS: Twenty-seven publications were identified, including six randomized, controlled trials ascertaining with health related QoL (n = 1830 PwPs). The qualitative evaluation revealed that PN contribute to all aspects of personalized care. The meta-analysis showed no improved QoL in personalized care models compared to standard care, thought a great heterogeneity among study design and interventions was outlined (Standardized Mean Difference = -0.8935; 95% Confidence Interval, -2.1177 to 0.3307; z = -1.43, p = 0.1526). CONCLUSION: PN fulfil important functions in personalized PD care. For the future, a clear role definition will be necessary to adjust training for PN across healthcare systems and care settings but especially to realize their full potential for PD care.
AU  - van Munster, M.*
AU  - Stümpel, J.*
AU  - Thieken, F.*
AU  - Ratajczak, F.
AU  - Rascol, O.*
AU  - Fabbri, M.*
AU  - Clemens, T.L.*
AU  - Czabanowska, K.*
AU  - Mestre, T.A.*
AU  - Pedrosa, D.J.*
C1  - 65668
C2  - 52878
SP  - 1807-1831
TI  - The role of parkinson nurses for personalizing care in parkinson's disease: A systematic review and meta-analysis.
JO  - J. Parkinsons Dis.
VL  - 12
IS  - 6
PY  - 2022
SN  - 1877-7171
ER  - 

TY  - JOUR
AB  - Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using F-18-FDG-PET as a biomarker of synaptic function.Methods: Thirty-six iRBD patients (64.1 +/- 6.5 y, 32 M), 72 PD patients, and 79 controls (65.6 +/- 9.4 y, 53 M) underwent brain F-18-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4 +/- 8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8 +/- 6.6 y, 29 M) of RBD. F-18-FDG-PET scans were used to independently discriminate subjects belonging to four categories: controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes).Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions.Conclusion: Data-driven approach to brain F-18-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.
AU  - Arnaldi, D.*
AU  - Meles, S.K.*
AU  - Giuliani, A.*
AU  - Morbelli, S.*
AU  - Renken, R.J.*
AU  - Janzen, A.*
AU  - Mayer, G.*
AU  - Jonsson, C.*
AU  - Oertel, W.H.
AU  - Nobili, F.*
AU  - Leenders, K.L.*
AU  - Pagani, M.*
AU  - REMPET Study Group*
C1  - 55507
C2  - 46314
CY  - Nieuwe Hemweg 6b, 1013 Bg Amsterdam, Netherlands
SP  - 229-239
TI  - Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in parkinson's disease.
JO  - J. Parkinsons Dis.
VL  - 9
IS  - 1
PB  - Ios Press
PY  - 2019
SN  - 1877-7171
ER  -