TY  - JOUR
AB  - PURPOSE: To quantify neuroanatomical changes using magnetic resonance imaging (MRI) in patients with cerebral metastasized breast cancer after brain radiotherapy (RT). METHODS: Fifteen patients with breast cancer with brain metastases who underwent whole brain RT (WBR), radiosurgery (RS), and/or hypofractionated stereotactic treatment (STX) were examined at four time points (TPs). A total of 48 MRIs were available: prior to RT (TP1), 5-8 months after RT (TP2), 9-11 months after RT (TP3), and >20 months after RT (TP4). Using automatic segmentation, 25 subcortical structures were analyzed. Patients were split into three groups: STX (receiving STX and RS), RS (receiving RS only), and WBR (receiving WBR at least once). After testing for a normal distribution for all values using the Kolmogorov-Smirnov test, a two-sided paired t test was used to analyze volumetric changes. For those values that were not normally distributed, the nonparametric Mann-Whitney test was employed. RESULTS: The left cerebellum white matter (p = 0.028), the right pallidum (p = 0.038), and the left thalamus (p = 0.039) significantly increased at TP2 compared to TP1. The third ventricle increased at all TPs (p = 0.034-0.046). The left choroid plexus increased at TP3 (p = 0.037) compared to TP1. The left lateral ventricle increased at TP3 (p = 0.012) and TP4 (p = 0.027). Total gray matter showed a trend of volume decline in STX and WBR groups. CONCLUSIONS: These findings indicate that alterations in the volume of subcortical structures may act as a sensitive parameter when evaluating neuroanatomical changes and brain atrophy due to radiotherapy. Differences observed for patients who received STX and WBR, but not those treated with RS, need to be validated further.
AU  - Reibelt, A.*
AU  - Mayinger, M.*
AU  - Borm, K.J.*
AU  - Combs, S.E.
AU  - Duma, M.N.*
C1  - 62582
C2  - 50958
CY  - 1 Olivers Yard, 55 City Road, London Ec1y 1sp, England
SP  - 486-494
TI  - Neuroanatomical changes seen in MRI in patients with cerebral metastasized breast cancer after radiotherapy.
JO  - Tumori
VL  - 108
IS  - 5
PB  - Sage Publications Ltd
PY  - 2022
SN  - 0300-8916
ER  - 

TY  - JOUR
AB  - Background: The purpose of this study is to detect a correlation between the preradiation tumor staging and the relative volumetric regression of the primary tumor through external beam radiation therapy (EBRT). Methods: Clinical data of 32 patients with a mean age of 60 +/- 12 years treated with primary radiation therapy (RT) of cervical carcinoma were analyzed. Union Internationale Contre le Cancer (UICC) stages were T1 = 4 patients, T2 = 15 patients, T3 = 8 patients, T4 = 5 patients; N1 = 26 patients, N0 = 6 patients; and M0 = 25 patients, M1 = 7 patients. All patients received pelvic magnetic resonance imaging (MRI) before RT as well as during RT. The cervical primary tumor was delineated as gross tumor volume (ptGTV) in T2-weighted MRI sequences. We compared ptGTV reduction by stage, lymph node status, metastatic status, and grading. Results: Mean ptGTV reduction during RT was 61.4 +/- 28.9%. T1 tumors shrank by 88.2 +/- 13.4%, T2 by 67.6 +/- 28.7%, T3 by 50.8 +/- 23.6%, and T4 by 38.7 +/- 27.2%. The difference in tumor shrinkage was statistically significant between the lower T stages and the higher T stages (p< 0.05). There was no statistical difference in the mean ptGTV before treatment in the group with lymph node metastases (LNM) (54.1 +/- 47.7 cm(3)) as compared to the group without LNM (76.6 +/- 52.2 cm(3)). Nonetheless, ptGTV shrank significantly differently: by 68.9 +/- 25.7% (N1 patients) and by 29.0 +/- 17.7% (N0 patients). No significant differences in ptGTV shrinkage were observed in M0 versus M1 and G2 versus G3 tumors. Conclusion: There is a correlation between mean ptGTV reduction during EBRT and tumor stages. Tumors with higher T stages shrank less under radiation treatment, and the ptGTV of N1 patients responded better than that of N0 patients.
AU  - Arend, F.*
AU  - Oechsner, M.*
AU  - Weidenbächer, C.B.*
AU  - Combs, S.E.
AU  - Borm, K.J.*
AU  - Duma, M.N.*
C1  - 59756
C2  - 49037
CY  - 1 Olivers Yard, 55 City Road, London Ec1y 1sp, England
SP  - 139-144
TI  - Correlations of UICC tumor stage and tumor regression on T2-weighted MRI sequences during definitive radiotherapy of cervical cancer.
JO  - Tumori
VL  - 107
IS  - 2
PB  - Sage Publications Ltd
PY  - 2020
SN  - 0300-8916
ER  -